Zhuanzhuan Su

Whole-transcriptome profiling of the fat body identifies aae-miR-283–ApoLp-Ⅱ/Ⅰ regulation associated with lipid transport and ovarian development in Aedes aegypti

Xiaolin Yang, H REN, Wenzhuo Zhao, Meng Huang et autres

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Ligand-Controlled Regioselective Deuteration of Indoles: Anti-C3 Selectivity and Mechanistic Insights

Shuaizhong Zhang, Liping Chen, Zhuanzhuan Su, Defa Gu et autres

We report a ligand-controlled, regiodivergent deuteration of indoles. Both ligands exhibit anti-selectivity against the electron-rich C3 position: the indazole-pyridone ligand enables deuteration at all sites, except C3, while the NAP ligand delivers exclusive C2 selectivity. Density functional theory (DFT) calculations reveal that …

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Competing endogenous RNAs (ceRNAs) orchestrate a gene regulatory network in the Aedes aegypti midgut in response to blood feeding

Yujiao Han, Qingshan Ou, Zhuanzhuan Su, X Wang et autres

Aedes aegypti, a globally widespread mosquito, is a key public health threat due to its ability to transmit multiple deadly arboviruses. The midgut is crucial for the survival, reproduction, and disease transmission of mosquitoes. Competing endogenous RNAs (ceRNAs) regulate gene expression by …

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Computational Insights into Divergent Pd-Catalyzed Oxidations with Oxone: Unveiling Dual Wacker and Oxo-Hydroxylation Pathways

Zhuanzhuan Su, Liping Chen, Shuaizhong Zhang, Xianwen Zeng et autres

High Resolution Image Download MS PowerPoint Slide Pd(II)-catalyzed Wacker oxidation represents a robust and attractive route to methyl ketones from terminal alkenes in modern organic synthesis. In this work, we report a tunable oxidation system that employs oxone (potassium peroxymonosulfate) as a …

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Purine nucleoside phosphorylase mediates midgut physiological functions in Aedes aegypti by orchestrating uric acid biosynthesis and oxidative stress homeostasis

H REN, Xiaolin Yang, Xin Wang, Zhuanzhuan Su et autres

Insects excrete nitrogenous waste primarily through the synthesis of uric acid, with purine nucleoside phosphorylase (PNP; AAEL002269) serving as a critical enzyme in this metabolic pathway. Downregulation of PNP has been shown to significantly disrupt blood digestion, ovarian development, and adult longevity …

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TarP: A microRNA target gene prediction tool utilizing a polymorphic structured alignment approach

Ting Fan, Zhuanzhuan Su, Xin Wang, Lu Zhao et autres

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Serine Hydroxymethyltransferase Modulates Midgut Physiology in Aedes aegypti Through miRNA Regulation: Insights from Small RNA Sequencing and Gene Expression Analysis

Qian Pu, Yujiao Han, Zhuanzhuan Su, H REN et autres

Aedes aegypti mosquitoes are critical vectors of arboviruses, responsible for transmitting pathogens that pose significant public health challenges. Serine hydroxymethyltransferase (SHMT), a key enzyme in one-carbon metabolism, plays a vital role in various biological processes, including DNA synthesis, energy metabolism, and cell …

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Dual-Path Large Kernel Learning and Its Applications in Single-Image Super-Resolution

Zhuanzhuan Su, Mang Sun, He Jiang, Xiang Ma et autres

To enhance the performance of super-resolution models, neural networks frequently employ module stacking. However, this approach inevitably results in an excessive proliferation of parameter counts and information redundancy, ultimately constraining the deployment of these models on mobile devices. To surmount this limitation, …

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Single Image Super-Resolution via Wide-Activation Feature Distillation Network

Zhuanzhuan Su, Wang Yu-ze, Xiang Ma, Mang Sun et autres

Feature extraction plays a pivotal role in the context of single image super-resolution. Nonetheless, relying on a single feature extraction method often undermines the full potential of feature representation, hampering the model's overall performance. To tackle this issue, this study introduces the …

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Sex-specific impacts of thimerosal on the behaviors and brain monoaminergic systems in zebrafish (Danio rerio)

Xuchun Qiu, Zhuanzhuan Su, Jiarui Gao, Yiming Cui et autres

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CpG island evolution in the mammalian DHRS4 gene cluster and its role in the regulation of gene transcription

Zhuanzhuan Su, G. Liu, Xiao Song, Bin Liang et autres

The dehydrogenase/reductase (SDR family) member 4 (DHRS4) gene is copied during mammalian evolution; therefore, while only one DHRS4 gene is expressed in the mouse genome, the gene cluster consists of two (DHRS4 and DHRS4L1) and three (DHRS4, DHRS4L2, and DHRS4L1) copies in …

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Activation of Ras/Raf protects cells from melanoma differentiation-associated gene-5-induced apoptosis

Lili Lin, Zhuanzhuan Su, Irina V. Lebedeva, Pankaj Gupta et autres

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