Accès ouvert
2025
article
OpenAlex
Pamela C.L. Ferreira, Guilherme Povala, Bruna Bellaver, Guilherme Bauer‐Negrini et autres
BACKGROUND: Plasma phosphorylated tau (p-tau) has been used as a pre-screening tool in clinical trials. Using plasma p-tau for pre-screening may help identify individuals more likely to be Aβ-PET positive, reducing the number of PET scans needed at enrollment and decreasing recruitment …
us, br, kr, ca
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Accès ouvert
2025
article
OpenAlex
Manuella Edler Zandoná Giordani, Bárbara Loeblein Uebel, Victória Tizeli Souza, Simone Sieben da Mota et autres
BACKGROUND: Subjective cognitive decline (SCD), or self-perceived cognitive impairment, is a recognized risk factor for future cognitive decline and dementia. Analyzing Alzheimer's disease (AD) biomarkers in SCD populations could provide a means to identify preclinical AD and enable early intervention strategies. We …
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Accès ouvert
2025
article
OpenAlex
Luiza Santos Machado, Guilherme Povala, Ilaria Pola, Dzeneta Vizlin‐Hodzic et autres
Abstract Background Astrocytes are highly involved in Alzheimer’s disease (AD) pathophysiology. GFAP, an astrocyte‐enriched protein, increases in response to amyloid (Aβ) pathology and is used as a fluid biomarker of astrocyte reactivity in AD. However, GFAP does not fully reflect the astrocytic …
se, us, ca, br
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Accès ouvert
2025
article
OpenAlex
Álvaro de Oliveira Franco, Eduardo R. Zimmer, Raphael Machado Castilhos
BACKGROUND: Early menopause (EM) is a potential risk factor for cognitive impairment, yet its impact remains underexplored in low- and middle-income countries, where modifiable risk factors play a key role in dementia development. This study investigates how EM, hormone therapy (HT), and …
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Accès ouvert
2025
article
OpenAlex
Joana Emilia Senger, Marco De Bastiani, Lucas Uglione Da Ros, Eduardo R. Zimmer et autres
BACKGROUND: Identifying modifiable risk factors to address the rising rates of dementia has become a priority. In this context, loneliness has emerged as a key factor associated with cognitive decline. This study aimed to examine the relationship between loneliness, social isolation, and …
br
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Accès ouvert
2025
article
OpenAlex
Hernan Hernandez, Hernando Santamaría‐García, Sebastián Moguilner, Agustina Legaz et autres
BACKGROUND: Global health challenges like aging and dementia are shaped by socioeconomic disparities, environmental factors, and social determinants of health. We developed a behavioral age gap (BAG), measuring the difference between expected behavioral age and chronological age METHOD: We utilized a cross-sectional …
cl, co, us, ar, Égypte, Nigéria, gb, br, Cameroun, in, Kenya, ie, be, au
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Accès ouvert
2025
article
OpenAlex
Ana Carolina Gomes, Sephora Sabrina Candido de Almeida, Eduardo R. Zimmer, Diogo Haddad Santos et autres
BACKGROUND: Anti-amyloid therapy has emerged as a promising approach for Alzheimer's disease (AD), aiming to reduce beta-amyloid plaques, a hallmark of the disease. However, global access to these therapies remains uneven, raising concerns about equity and representation in real-world clinical use. METHOD: …
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