Simone Sieben da Mota

Association of blood ptau‐217 with Memory Performance and APOE ε4 in Individuals with Subjective Cognitive Decline: insights from the BRASCODE Cohort

Manuella Edler Zandoná Giordani, Bárbara Loeblein Uebel, Victória Tizeli Souza, Simone Sieben da Mota et autres

BACKGROUND: Subjective cognitive decline (SCD), or self-perceived cognitive impairment, is a recognized risk factor for future cognitive decline and dementia. Analyzing Alzheimer's disease (AD) biomarkers in SCD populations could provide a means to identify preclinical AD and enable early intervention strategies. We …

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Effect of cognitive reserve on cognitive performance in Subjective Cognitive Decline: insights from the BRASCODE Cohort

Manuella Edler Zandoná Giordani, Bárbara Loeblein Uebel, Victória Tizeli Souza, Simone Sieben da Mota et autres

BACKGROUND: Cognitive reserve refers to the brain's capacity to maintain performance despite pathology and may influence the risk of cognitive decline. Therefore, studying the effect of cognitive reserve on older adults with memory complaints can provide insights into their cognitive trajectories and …

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Assessment of the mild behavioral impairment checklist in individuals with subjective cognitive decline and mild cognitive impairment in the BRASCODE cohort

Victória Tizeli Souza, Bárbara Loeblein Uebel, Gabriela Raquel Paz Rivas, Simone Sieben da Mota et autres

BACKGROUND: Mild Behavioral Impairment (MBI) is characterized by neuropsychiatric symptoms that may precede cognitive decline in the early stages of neurodegenerative diseases. In Brazil, the study of MBI in individuals with cognitive complaints remains limited. This study aims to evaluate the MBI-Checklist …

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Sleep complaints in individuals with subjective cognitive decline from a south‐brazilian cohort

Gabriela Raquel Paz Rivas, Bárbara Loeblein Uebel, Victória Tizeli Souza, Simone Sieben da Mota et autres

BACKGROUND: Subjective cognitive decline (SCD) is defined as self-perceived cognitive impairment in individuals who remain cognitively unimpaired (CU). SCD is considered an early manifestation within the continuum of neurodegenerative diseases, its etiology is heterogeneous and not fully elucidated. Emerging evidence suggests that …

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Impact of APOE ε4 on Cognitive Progression in Individuals with Subjective Cognitive Decline: Preliminary Data from a Brazilian Cohort

Bruno de Oliveira De Marchi, Bárbara Loeblein Uebel, Victória Tizeli Souza, Simone Sieben da Mota et autres

BACKGROUND: Subjective cognitive decline (SCD) and apolipoprotein E (APOE) ε4 allele are known risk factors for Alzheimer's disease (AD). However, the impact of APOE ε4 on cognitive progression in individuals with SCD remains unclear. The aim of this study is to evaluate …

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Mild behavioral impairment checklist: assessment in individuals with subjective and mild cognitive decline from the BRASCODE cohort

Victória Tizeli Souza, Bárbara Loeblein Uebel, Gabriela Raquel Paz Rivas, Simone Sieben da Mota et autres

Background: Mild Behavioral Impairment (MBI) is defined as the later-life emergence of sustained neuropsychiatric symptoms not better explained by other psychiatric disorders. In Brazil, research on MBI in cognitively unimpaired older adults remains limited. This study aims to evaluate the Mild Behavioral …

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Mild Behavioral Impairment in individuals with subjective cognitive decline and mild cognitive impairment in Southern Brazil

Victória Tizeli Souza, Simone Sieben da Mota, Gabriela Raquel Rivas Paz, Bruno de Oliveira De Marchi et autres

BACKGROUND: Mild Behavioral Impairment (MBI) is a construct developed to capture neuropsychiatric symptoms in individuals in early stages of neurodegenerative diseases. The assessment of MBI in individuals with preclinical cognitive manifestations in Brazil is still quite limited. The aim of this study …

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Sleep complaints associates with anxiety in individuals with Subjective Cognitive Decline from a South‐Brazilian cohort

Gabriela Raquel Paz Rivas, Victória Tizeli Souza, Simone Sieben da Mota, Bruno de Oliveira De Marchi et autres

BACKGROUND: Subjective cognitive decline (SCD) is defined by the presence of cognitive complaints in cognitively unimpaired (CU) individuals. Despite being part of the continuum of a neurodegenerative disease, the cause of the cognitive complaint is quite heterogeneous. Sleep disturbances may be associated …

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Should the perspective of subjective memory decline differ between cognitively unimpaired individuals and their informants? Baseline results of the BRASCODE Cohort

Rhaná Carolina Santos, Sarah Vitória Bristot Carnevalli, Haniel Bispo De Souza, Victória Tizeli Souza et autres

Abstract Background Subjective Cognitive Decline (SCD) is characterized by cognitive complaints in cognitively unimpaired (CU) individuals. Its condition displays considerable heterogeneity etiologies, including neurodegenerative diseases. Our aim is to compare the memory complaints between patients with SCD and their informants in the …

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Brazilian Subjective Cognitive Decline (BRASCODE) Cohort: baseline sociodemographic and clinical data

Ana Letícia Amorim de Albuquerque, Manuella Edler Zandoná Giordani, Victória Tizeli Souza, Simone Sieben da Mota et autres

Abstract Background Subjective cognitive decline (SCD) is the self‐perceived impairment of cognitive function and has been studied as a risk factor for objective cognitive impairment. Monitoring patients with SCD can aid in understanding the risk factors for dementia in low‐ and middle‐income …

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Brazilian Subjective Cognitive Decline (BRASCODE) Cohort: protocol and preliminary results

Raphael Machado Castilhos, Manuella Edler Zandoná Giordani, Simone Sieben da Mota, Bruno de Oliveira De Marchi et autres

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Informant and patient-reported subjective cognitive decline: a preliminary analysis of the Brazilian subjective Cognitive Decline Cohort

Raphael Machado Castilhos, Haniel Bispo De Souza, Manuella Edler Zandoná Giordani, Simone Sieben da Mota et autres

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