Hernando A Santamaría‐García

Predicting attitudinal and behavioral responses to COVID-19 pandemic using machine learning.

Jonathan Albert Fugelsang, Andrej Findor, Michèle D. Birtel, Michael Jason Bernstein et autres

At the beginning of 2020, COVID-19 became a global problem. Despite all the efforts to emphasize the relevance of preventive measures, not everyone adhered to them. Thus, learning more about the characteristics determining attitudinal and behavioral responses to the pandemic is crucial …

The landscape of dementia research, diagnosis, treatment, and care in Latin America

Claudia K. Suemoto, Nilton Custodio, Diego Alonso Gómez Aguilar, José A. Avila‐Funes et autres

Latin America is undergoing rapid population aging alongside a rising burden of dementia. While the region holds substantial potential for dementia risk reduction, challenges remain, such as delayed diagnoses, limited access to specialized care and biomarker testing, persistent stigma, and deep-rooted structural …

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Association of apolipoprotein E variants on Alzheimer's disease in Latin America: A systematic review and meta‐analysis

Paulina Orellana, Ariel Caviedes, Liset Gonzalez, Carolina Ochoa‐Rosales et autres

The apolipoprotein E (APOE) ε4 allele represents the strongest genetic risk factor for Alzheimer's disease (AD), but its role in genetically diverse Latin American and Caribbean (LAC) populations is underexplored. We conducted a meta-analysis of 35 studies from 11 LAC countries, encompassing …

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The biological burden of conflict across populations worldwide

Juan F. Cardona, Hernando A Santamaría‐García, Agustín Ibáñez

Contemporary societies are increasingly shaped by multilayered forms of interindividual and intergroup conflict that transcend traditional political or military boundaries.1,2 Violence, forced migration, environmental degradation, institutional fragility and widening social and political polarisation interact to generate complex forms of adversity that affect …

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Predicting accelerated and delayed aging in global settings: biobehavioral age gaps and the role of global exposomes

Hernan Hernandez, Hernando A Santamaría‐García, Sebastián Moguilner, Agustina Legaz et autres

Background: Global health challenges like aging and dementia are shaped by socioeconomic disparities, environmental factors, and social determinants of health. We developed a behavioral age gap (BAG), measuring the difference between expected behavioral age and chronological age Method: We utilized a cross‐sectional …

Computational whole-body-exposome models for global precision brain health

Agustín M. Ibáñez, Claudia A. Duran-Aniotz, Joaquín Migeot, Sandra Báez et autres

The worldwide rise of neurological and psychiatric conditions poses major challenges. However, current global research remains fragmented, dominated by limited cohorts and poorly integrated datasets that disconnect whole-body health, exposome, and brain health. Theories rarely unify brain measures with extracerebral factors or …

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The harming power of shame

Brian Lawlor, Sandra Baez, Hernando A Santamaría‐García, Agustín M. Ibáñez

Shame is a pervasive, multidimensional emotion influencing brain, body and social life. While shame can foster accountability, its toxic forms drive stigma, withdrawal and mental illness. We call for systemic, culturally sensitive interventions to transform phatological shame into healing, fostering empathy, accountability …

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Cardiovascular risk factors and the allostatic interoceptive network in dementia

Jessica L. Hazelton, Joaquin Migeot, Raul Gonzalez‐Gomez, Florencia Altschuler et autres

BACKGROUND: Cardiovascular risk factors, such diabetes, hypertension, blood pressure, obesity, and smoking, are linked with allostatic-interoception - the continuous monitoring of internal bodily states in anticipation of environmental demands. These risk factors are associated with dementia risk. How these factors affect brain …

au, cl, ar, us, es, co, pe, mx, br (code pays fourni par la source)

Predicting accelerated and delayed aging in global settings: biobehavioral age gaps and the role of global exposomes

Hernan Hernandez, Hernando A Santamaría‐García, Sebastián Moguilner, Agustina Legaz et autres

BACKGROUND: Global health challenges like aging and dementia are shaped by socioeconomic disparities, environmental factors, and social determinants of health. We developed a behavioral age gap (BAG), measuring the difference between expected behavioral age and chronological age METHOD: We utilized a cross-sectional …

cl, co, us, ar, Égypte, Nigéria, gb, br, Cameroun, in, Kenya, ie, au (code pays fourni par la source)

The Role of Allostatic Load in Cognitive Impairment and Dementia in Latin America Population

Nickole P. Marin‐Díaz, Matías Pizarro, Hernan Hernandez, Carolina Ochoa‐Rosales et autres

BACKGROUND: Latin America (LA) experiences disparities driven by social determinants of health and low socioeconomic status, which increase the risk of dementia. These adverse factors may contribute to dementia through allostasis, the body's adaptive response to stressors. Chronic stressors can lead to …

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Validation of plasma p ‐tau217 as a Blood‐Based Biomarker for dementia diagnosis in Latin American population

Ariel Caviedes, Felipe Cabral‐Miranda, Paulina Orellana, Carolina Gonzalez‐Silva et autres

Abstract Background Plasma biomarkers have immense potential to transform dementia diagnosis globally, with phosphorylated tau 217 ( p ‐tau217) emerging as the most accurate AT(N) biomarker for diagnosis of Alzheimer's Disease (AD). Despite their promise, AT(N) biomarkers remain under‐validated in genetically and …

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Cardiovascular risk factors and the allostatic interoceptive network in dementia

Jessica L. Hazelton, Joaquin Migeot, Raul Gonzalez‐Gomez, Florencia Altschuler et autres

Abstract Background Cardiovascular risk factors, such diabetes, hypertension, blood pressure, obesity, and smoking, are linked with allostatic‐interoception – the continuous monitoring of internal bodily states in anticipation of environmental demands. These risk factors are associated with dementia risk. How these factors affect …

au, cl, ar, us, es, co, pe, mx, br (code pays fourni par la source)