Accès ouvert
2026
article
OpenAlex
Hamidreza Hojjat, Petra Henklein, Akvile Haeckel, Grit Nebrich et autres
Abstract Enzymes are often tightly regulated and exist in inactive forms. Therefore, rather than mere presence, it is the enzyme’s activity that catalyzes cellular and tissue functions. However, multiplex activity mapping of enzymes in situ is particularly challenging. To address this, we …
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Accès ouvert
2026
article
OpenAlex
Fei Ni, Akvile Haeckel, Hamidreza Hojjat, Mathias Schannor et autres
Abstract Objective Iron-based contrast agents (IBCAs) have potential as alternatives to Gd-based contrast agents (GBCAs), intending to address the long-term safety concerns associated with gadolinium. We investigated [Fe-EOB- t CDTA] as a potential alternative to [Gd-EOB-DTPA] 2 - for liver magnetic resonance …
de
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Accès ouvert
2026
other
OpenAlex
Fei Ni, Akvile Haeckel, Hamidreza Hojjat, Mathias Schannor et autres
Abstract Objective Iron-based contrast agents (IBCAs) have potential as alternatives to Gd-based contrast agents (GBCAs), intending to address the long-term safety concerns associated with gadolinium. We investigated [Fe-EOB-tCDTA] as a potential alternative to [Gd-EOB-DTPA]2- for liver magnetic resonance imaging (MRI). Materials and …
de
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Accès ouvert
2026
article
OpenAlex
Fei Ni, Akvile Haeckel, Hamidreza Hojjat, Mathias Schannor et autres
Additional file 1: Fig. S1 HPLC results for EOB-tCDTA (a) and Fe-EOB-tCDTA before (b) and after (c) autoclaving. Method: gradient reverse phase; mobile phase: 2-66% acetonitrile with ammonium bicarbonate at PH 7.8. Flow rate: 1.0 mL/min for 20 min. The retention time …
de
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Accès ouvert
2026
article
OpenAlex
Fei Ni, Akvile Haeckel, Hamidreza Hojjat, Mathias Schannor et autres
Additional file 1: Fig. S1 HPLC results for EOB-tCDTA (a) and Fe-EOB-tCDTA before (b) and after (c) autoclaving. Method: gradient reverse phase; mobile phase: 2-66% acetonitrile with ammonium bicarbonate at PH 7.8. Flow rate: 1.0 mL/min for 20 min. The retention time …
de
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Accès ouvert
2026
dataset
OpenAlex
Hamidreza Hojjat, Petra Henklein, Akvile Haeckel, Grit Nebrich et autres
This repository contains raw mass spectrometry imaging data associated with the study “Multiplexed Enzyme Activity Microscopy by Semiquantitative, Ratiometric Enzyme Activity MALDI Mass Spectrometry Imaging”. Raw MALDI-MSI datasets are provided in the open imzML format as paired .imzML and .ibd files. Calibration …
de
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2025
article
OpenAlex
Feng Ni, Akvile Haeckel, Hamidreza Hojjat, Honglan Mi et autres
PURPOSE: This study evaluated the T1 enhancement of the 2 iron-based contrast agents (IBCAs), [Fe( trans-t CDTA)] + and [Fe( trans-Di-t CDTA)], in blood and other organs compared with a gadolinium-based contrast agent (GBCA) in DCE-MRI, as well as their in vitro …
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Accès ouvert
2025
article
OpenAlex
Yang Liu, Akvile Haeckel, Nicola Beindorff, Simon Poetzsch et autres
The virus protein CAV-Apoptin and its homologue HGV-Apoptin selectively kill cancer cells but are not suitable for systemic treatment. The aim was to develop Apoptin-based fusion proteins for intravenous application in cancer therapy, which also contain the hydrophilic polypeptide XTEN, a cleavage …
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