Accès ouvert
2025
article
OpenAlex
Yang Liu, Akvile Haeckel, Nicola Beindorff, Simon Poetzsch et autres
The virus protein CAV-Apoptin and its homologue HGV-Apoptin selectively kill cancer cells but are not suitable for systemic treatment. The aim was to develop Apoptin-based fusion proteins for intravenous application in cancer therapy, which also contain the hydrophilic polypeptide XTEN, a cleavage …
de
(code pays fourni par la source)
2023
article
OpenAlex
Simon Poetzsch, J. Focke, Nicola Beindorff, L. Winkler et autres
Ziel/Aim The aim of this work was to establish and characterize a glioblastoma multiforme (GBM) mouse model with different orthotopic tumors by imaging as a basis for future in vivo testing of novel brain tracers and radiotherapeutics. Methodik/Methods Nineteen eight-week-old female GBM …
de
(code pays fourni par la source)
2022
article
OpenAlex
Federico Salsi, Ulrich Abram, Winfried Brenner, Simon Poetzsch et autres
2021
article
OpenAlex
Simon Poetzsch, Winfried Brenner, Sarah Spreckelmeyer
BACKGROUND: For radiopharmaceuticals, aseptic preparation in combination with filtration is the most commonly used sterilizing method. In general, the production of radiopharmaceuticals needs to fulfil the requirements of good manufacturing practice. In the scope of this work, we focused on the positron …
de
(code pays fourni par la source)
2021
conference-paper
OpenAlex
Sarah Spreckelmeyer, Matthias Norbert Balzer, Simon Poetzsch, Winfried Brenner
Ziel/Aim [ 68 Ga]Ga-FAPI-46 is a promising radiopharmaceutical for in vivo detection of the fibroblast activation protein by positron emission tomography. Until now, the synthesis of [ 68 Ga]Ga-FAPI-46 has been performed manually [ 1 ],[ 2 ]. Our aim was to …
de
(code pays fourni par la source)
2021
conference-paper
OpenAlex
Simon Poetzsch, Winfried Brenner, Sarah Spreckelmeyer
Ziel/Aim For radiopharmaceuticals, aseptic preparation in combination with filtration is the most chosen sterilizing method. In general, the production of radiopharmaceuticals needs to fulfil the requirements of good manufacturing practice. In the scope of this work, we focused on the positron emitter …
de
(code pays fourni par la source)
Accès ouvert
2020
article
OpenAlex
Sarah Spreckelmeyer, Matthias Norbert Balzer, Simon Poetzsch, Winfried Brenner
Abstract Background [68Ga]Ga-FAPI-46 is a promising radiopharmaceutical for in vivo detection of the fibroblast activation protein by positron emission tomography. Until now, the synthesis of [68Ga]Ga-FAPI-46 has been only performed manually. Our aim was to evaluate the automated synthesis of this radiopharmaceutical …
de
(code pays fourni par la source)
Accès ouvert
2020
preprint
OpenAlex
Simon Poetzsch, Winfried Brenner, Sarah Spreckelmeyer
Abstract Background For radiopharmaceuticals, aseptic preparation in combination with filtration is the most chosen sterilizing method. In general, the production of radiopharmaceuticals needs to fulfil the requirements of good manufacturing practice. In the scope of this work, we focused on the positron …
de, us
(code pays fourni par la source)