Yufeng Wang

Overexpression of JAML in colorectal cancer cells predicts higher radiosensitivity by inactivating ATR pathway

Yanan Liu, Yufeng Wang, Yinying Dong, Chunsheng Yang et autres

Background Junctional adhesion molecule–like protein (JAML) is highly expressed in cancer tissues of patients with colorectal cancer (CRC) and promotes cancer proliferation. However, the relationship between JAML expression and radiosensitivity of CRC remains unclear. Methods Stable CRC cell lines with knocked down …

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Barriers to and facilitators of integrated care for community-dwelling frail older adults: A qualitative study applying implementation science frameworks

Jiaqi Yu, Hejing Chen, Yang Yang, Xuanzhi Liu et autres

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Intensive Blood Pressure Control in Patients With Diabetes and Previous Stroke: A Post‐Hoc Analysis of ACCORD‐BP Trial

Jue Wang, Liu He, Chao Jiang, Yufeng Wang et autres

Intensive systolic blood pressure (SBP) control reduces cardiovascular outcomes in hypertensive patients, but its effects in those with diabetes and prior stroke need further evidence. Among 4733 patients with elevated SBP enrolled in the ACCORD-BP (Action to Control Cardiovascular Risk in Diabetes-Blood …

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Co-ablation of lung malignancies with coexisting usual interstitial pneumonia: a retrospective analysis of safety and efficacy

Yufeng Wang, Xiaoguang Li

PURPOSE: This retrospective study aimed to evaluate the feasibility and safety of co-ablation (Co-A) for lung malignancies in patients with usual interstitial pneumonia (UIP). MATERIALS AND METHODS: We retrospectively reviewed the clinical records of 1,537 consecutive patients treated for malignant lung tumors. …

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Quality assurance of quantitative MRI protocol for a hypoxia imaging clinical study in glioblastoma

Yufeng Wang, James Drummond, Marco Mueller, Paul Keall et autres

Motivation: A quantitative MRI (qMRI) protocol was developed for a clinical study aimed at identifying regions of tumour hypoxia in glioblastoma patients. Technical validation of qMRI biomarkers requires thorough testing of the protocol against reference standards. Goal(s): To assess and report accuracy, …

The Potential Treatment Options and Combination Strategies of KRAS-Mutated Lung Cancer

Xinchao Zhao, Yawen Zheng, Yufeng Wang, Mingyan Zhang et autres

Abstract: In non-small cell lung cancer (NSCLC), Kirsten rat sarcoma viral oncogene homolog (KRAS) mutations are found in up to 30% of all cases, with the most prevalent mutations occurring in codons 12 and 13. The development of KRAS -targeted drugs like …

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Relationship between physical activities and mental health in older people: a bibliometric analysis

Y. Zhang, Mei Zhou, Zhihua Yin, Yufeng Wang

Objective: To summarize the general situation and focal points of research on the physical activity and mental health of older people over the past 15 years and provide references for future research. Methods: Literature published between January 1, 2009, and December 31, …

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Protocol for a randomized controlled trial of intensive blood pressure control on cardiovascular risk reduction in patients with atrial fibrillation: Rationale and design of the CRAFT trial

Chao Jiang, Zhiyan Wang, Xin Du, Yufeng Wang et autres

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Efficiency and Durability of EIVOM on Acute Reconnection After Mitral Isthmus Bidirectional Block

Caihua Sang, Deyong Long, Xiaowen Bo, Yiwei Lai et autres

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Association between blood pressure variability and risk of kidney function decline in hypertensive patients without chronic kidney disease: a post hoc analysis of Systolic Blood Pressure Intervention Trial study

Zhiyan Wang, Wenjie Li, Chao Jiang, Jue Wang et autres

BACKGROUND: Blood pressure variability (BPV) is a risk factor for poor kidney function independent of blood pressure (BP) in chronic kidney disease (CKD). Little is known about the association between kidney function decline and BPV in hypertensive patients without CKD. METHODS: A …

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Effect of Intensive Blood Pressure Control on Cardiovascular Outcomes in Cancer Survivors

Wenjie Li, Zhiyan Wang, Chao Jiang, Chang Hua et autres

BACKGROUND: To evaluate whether cancer modifies the effect of intensive blood pressure control on major cardiovascular outcomes. METHODS: Using data of the SPRINT (Systolic Blood Pressure Intervention Trial), we compared the risk of the composite outcomes of myocardial infarction, other acute coronary …

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Systolic Blood Pressure Time in Target Range and Incident Atrial Fibrillation in Patients With Hypertension: Insights From the SPRINT Trial

Jue Wang, Chao Jiang, Sitong Li, Zhiyan Wang et autres

BACKGROUND: Systolic blood pressure (SBP) time in target range (TTR) indicates the mean value, exposure time, and variability in blood pressure over time. The prognostic value of SBP TTR for incident atrial fibrillation (AF) in patients with hypertension is unclear. METHODS: We …

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