Accès ouvert
2026
preprint
OpenAlex
Kieran Didi, Danny Reidenbach, Matthew Penner, Supriya Ravichandran et autres
De novo protein design has advanced rapidly, yet designing binders to polar, solvent-exposed epitopes and small, flexible ligands remains challenging. Such hydrated surfaces and flexible molecules, including carbohydrates, provide few of the hydrophobic contacts favoured by current methods and have largely resisted …
gb, us, cn, de, dk, kr
(code pays fourni par la source)
Accès ouvert
2026
preprint
OpenAlex
Ho Yeung Chim, Mubarak Olanrewaju Idris, D. L. RIEGER, Phillip Schlegel et autres
Abstract Protein oligomers are ubiquitous in biological systems and essential for function. However, the de novo design of oligomers that controllably assemble in response to exogenous stimuli remains challenging. Here, we present an AI-based generative approach that leverages an interface-seeded strategy for …
de, ch
(code pays fourni par la source)
Accès ouvert
2025
article
OpenAlex
Alena Khmelinskaia, Neville P. Bethel, Farzad Fatehi, Bhoomika Basu Mallik et autres
Many naturally occurring protein assemblies have dynamic structures that allow them to perform specialized functions. Although computational methods for designing novel self-assembling proteins have advanced substantially over the past decade, they primarily focus on designing static structures. Here we characterize three distinct …
de, us, gb, ch, nl, tw
(code pays fourni par la source)