Denis S. Smirnov

Interactive effects of blood–brain barrier breakdown and Alzheimer's disease biomarker status on cognitive decline in older adults without dementia

Lauren Edwards, Amanda Inez Gonzalez, Kelsey R. Thomas, Denis S. Smirnov et autres

INTRODUCTION: Some research suggests that blood-brain barrier (BBB) integrity is altered in Alzheimer's disease (AD). Few studies have examined markers of BBB integrity and their interactions with AD risk factors on multi-domain cognition. METHODS: 83 older adults without dementia underwent lumbar puncture, …

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Skin Dermatomyositis with Concurrent Cutaneous Tuberculosis. A Clinical Case

R. G. Kovаlevа, M. N. Kondаkovа, А. V. Elkin, Denis S. Smirnov et autres

This article describes a clinical case of an extremely rare combination of two nosological types of skin lesions – dermatosis and cutaneous tuberculosis. It presents stages of diagnosis, which took 6 years and difficulties when choosing treatment. During the combination treatment (corticosteroids, …

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Cabozantinib-associated acquired perforating dermatosis

Denis S. Smirnov, Hillary C. Tsibris

Cabozantinib is a small molecule tyrosine kinase inhibitor (TKI) that prevents cancer progression and angiogenesis by targeting vascular endothelial growth factor (VEGF) receptor, as well as MET and AXL receptor tyrosine kinases. It is approved for use in several solid tumors, including …

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Cluster as a form of Resort Development: Organizational and Managerial Structure

Александр Николаевич Дунец, Angelina Penkova, Elena Potekhina, Olga V. Gribkova et autres

The article considers the prospect of forming a tourism cluster by the example of the existing resort Belokurikha. This is due to the historical background and concentration of tourist facilities, as well as the experience of joint project implementation by the cluster …

Gene signatures of tumor inflammation and epithelial-to-mesenchymal transition (EMT) predict responses to immune checkpoint blockade in lung cancer with high accuracy

Jeffrey C. Thompson, Wei‐Ting Hwang, Christiana W. Davis, Charuhas G. Deshpande et autres

OBJECTIVES: Treatment of non-small cell lung cancer (NSCLC) with immune checkpoint blockade (ICB) has resulted in striking clinical responses, but only in a subset of patients. The goal of this study was to evaluate transcriptional signatures previously reported in the literature in …

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Distinct structural correlates of the dominant and nondominant languages in bilinguals with Alzheimer's disease (AD)

Denis S. Smirnov, Alena Stasenko, David P. Salmon, Douglas R Galasko et autres

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Abstract 2134: Niraparib combined with abiraterone acetate inhibits the growth of BRCA2wtprostate tumors

Rajendra N. Damle, Rebecca Hawkins, Jennifer Hosbach, Georges Habineza Ndikuyeze et autres

Patients with metastatic prostate cancer may initially respond well to first- and second-generation androgen receptor (AR)-targeted therapies, but many will experience disease progression, indicating a need for alternative therapies. A subset of these patients bears prostate tumors that harbor deleterious mutations in …

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Abstract 4691: Evaluation of the NanoString’s Digital Spatial Profiling (DSP) technology in formalin-fixed paraffin embedded (FFPE) cell line mixtures, PBMCs and non-small cell lung cancer (NSCLC) tissues

Joshua James Rusbuldt, Tanesha Cash-Mason, Shaozhou Ken Tian, Alison VanSchoiack et autres

Evaluation of the NanoString’s Digital Spatial Profiling (DSP) Technology in Formalin-Fixed Paraffin Embedded (FFPE) cell line mixtures, PBMCs and Non-Small Cell Lung Cancer (NSCLC) tissuesPurpose: The complex nature of the tumor requires multiplexed, quantitative analysis of tissues which is challenging using immunohistochemistry …

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Abstract 1335: Digital droplet PCR (ddPCR)-based detection of androgen receptor splice variant 7 (AR-v7) in non-metastatic castration resistant prostate cancer

Mel Pilar Espaillat, Yashoda Rani Rajpurohit, Mike Gormley, Denis S. Smirnov et autres

Abstract Background: The androgen receptor (AR) is a clinically important driver in prostate cancer. In metastatic castration resistant prostate cancer (mCRPC), increased expression of the ligand-independent AR variant 7 (AR-v7) is a biomarker of hormonal therapy resistance. However, the prevalence and clinical …

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Synaptic biomarkers in CSF aid in diagnosis, correlate with cognition and predict progression in MCI and Alzheimer's disease

Douglas R Galasko, Mei-Fang Xiao, Desheng Xu, Denis S. Smirnov et autres

INTRODUCTION: Amyloid, Tau, and neurodegeneration biomarkers can stage Alzheimer's Disease (AD). Synaptic biomarkers may help track cognition. METHODS: In cognitively normal controls, Mild Cognitive Impairment (MCI) and AD, we investigated CSF biomarkers in relation to cognitive measures and as predictors of cognitive …

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