Mei-Fang Xiao

Altered NPTX2 dynamics associated with impaired cognitive aging

Rebecca P. Haberman, Ana R. Delgado, Mei-Fang Xiao, Ming Teng Koh et autres

Abstract Changes in synaptic integrity and neural activity homeostasis are hallmarks of brain aging and are closely tied to cognitive outcomes. Yet, defining their relationship across the continuum from normal aging to neurodegenerative disease has proven challenging. Recent research investigating the dynamic …

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A Novel Amino Acid‐Related Gene Signature Predicts Overall Survival in Patients With Hepatocellular Carcinoma

Shuyi Wang, Hong Huang, Xingwang Hu, Mei-Fang Xiao et autres

BACKGROUND AND AIMS: Hepatocellular carcinoma (HCC) is an extremely harmful malignant tumor in the world. Since the energy metabolism and biosynthesis of HCC cells are closely related to amino acids, it is necessary to further explore the relationship between amino acid-related genes …

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Neuronal pentraxin 2 correlates with neurodegeneration but not cognition in idiopathic normal pressure hydrocephalus (iNPH)

Megha A. Patel, Yifan Zhang, Mei-Fang Xiao, Paul F. Worley et autres

AIM OF THE STUDY: Neuronal pentraxin-2 (NPTX2) is a synaptic protein responsible for modulating plasticity at excitatory synapses. While the role of NPTX2 as a novel synaptic biomarker in cognitive disorders has been elucidated recently, its role in idiopathic normal pressure hydrocephalus …

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Sleep and circadian rhythm disruption by NPTX2 loss of function

Seung‐Eon Roh, Mei-Fang Xiao, Ana Isabel Delgado, Chuljung Kwak et autres

Sleep and circadian rhythm disruption (SCRD) is commonly observed in aging, especially in individuals who experience progressive cognitive decline to mild cognitive impairment (MCI) and Alzheimer's disease (AD). However, precise molecular mechanisms underlying the association between SCRD and aging are not fully …

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The neuronal pentraxin Nptx2 regulates complement activity and restrains microglia-mediated synapse loss in neurodegeneration

Jiechao Zhou, Sarah D. Wade, David R. Graykowski, Mei-Fang Xiao et autres

Complement overactivation mediates microglial synapse elimination in neurological diseases such as Alzheimer's disease (AD) and frontotemporal dementia (FTD), but how complement activity is regulated in the brain remains largely unknown. We identified that the secreted neuronal pentraxin Nptx2 binds complement C1q and …

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Neuronal pentraxin Nptx2 regulates complement activity in the brain

Jiechao Zhou, Sarah D. Wade, David R. Graykowski, Mei-Fang Xiao et autres

Abstract Complement overactivation mediates microglial synapse elimination in neurological diseases like Alzheimer’s disease and frontotemporal dementia (FTD), but how complement activity is regulated in the brain remains largely unknown. We identified that the secreted neuronal pentraxin Nptx2 binds complement C1q and thereby …

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Neuronal pentraxin 2 is required for facilitating excitatory synaptic inputs onto spinal neurons involved in pruriceptive transmission in a model of chronic itch

Kensho Kanehisa, Keisuke Koga, Sho Maejima, Yuto Shiraishi et autres

Abstract An excitatory neuron subset in the spinal dorsal horn (SDH) that expresses gastrin-releasing peptide receptors (GRPR) is critical for pruriceptive transmission. Here, we show that glutamatergic excitatory inputs onto GRPR+ neurons are facilitated in mouse models of chronic itch. In these …

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Correction: Boiten et al. Pathologically Decreased CSF Levels of Synaptic Marker NPTX2 in DLB Are Correlated with Levels of Alpha-Synuclein and VGF. Cells 2021, 10, 38

Walter A. Boiten, Inger van Steenoven, Mei-Fang Xiao, Paul F. Worley et autres

The authors want to notify that they have made the following changes to the author list of the paper [...].

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A biomarker-authenticated model of schizophrenia implicating NPTX2 loss of function

Mei-Fang Xiao, Seung‐Eon Roh, Jiechao Zhou, Daphne Chun-Che Chien et autres

Schizophrenia is a polygenetic disorder whose clinical onset is often associated with behavioral stress. Here, we present a model of disease pathogenesis that builds on our observation that the synaptic immediate early gene NPTX2 is reduced in cerebrospinal fluid of individuals with …

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VAMP-2 is a surrogate cerebrospinal fluid marker of Alzheimer-related cognitive impairment in adults with Down syndrome

Alberto Lleó, María Carmona‐Iragui, Laura Videla, Susana Fernández et autres

Abstract Background There is an urgent need for objective markers of Alzheimer’s disease (AD)-related cognitive impairment in people with Down syndrome (DS) to improve diagnosis, monitor disease progression, and assess response to disease-modifying therapies. Previously, GluA4 and neuronal pentraxin 2 (NPTX2) showed …

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VAMP-2 Is a Surrogate Cerebrospinal Fluid Marker of Alzheimer-related Cognitive Impairment in Adults With Down Syndrome

Alberto Lleó, María Carmona‐Iragui, Laura Videla, Susana Fernández et autres

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Pathologically Decreased CSF Levels of Synaptic Marker NPTX2 in DLB Are Correlated with Levels of Alpha-Synuclein and VGF

Walter A. Boiten, Inger van Steenoven, Mei-Fang Xiao, Paul Worley et autres

Background: Dementia with Lewy bodies (DLB) is a neurodegenerative disease where synaptic loss and reduced synaptic integrity are important neuropathological substrates. Neuronal Pentraxin 2(NPTX2) is a synaptic protein that drives the GABAergic inhibitory circuit. Our aim was to examine if NPTX2 cerebral …

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