Dae Young Lee

3102-LB: Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of DA-1726, an Oxyntomodulin Analogue: Phase 1 Higher-Dose Cohort Results

WEIKAI C. FANG, YUNA CHAE, Dae Young Lee, EUNJIN KIM et autres

Introduction and Objective: DA-1726 is an oxyntomodulin analogue, acting as a dual GLP-1/glucagon receptor agonist. In this first-in-human phase 1 study (NCT06252220), a higher-dose cohort further evaluated the safety, tolerability, pharmacokinetics (PK), and preliminary pharmacodynamics of DA-1726 in obese but otherwise healthy …

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Abstract 4591: SC3613 (IN-207387), a mutant-selective EGFR degrader, exhibits potent anti-tumor activity and improved safety profile in EGFR TKI-resistant NSCLC

J KIM, Jihoon Choi, Ok Young Lee, Young Jun Park et autres

Abstract Non-small cell lung cancer (NSCLC) accounts for approximately 85% of all lung cancers, with activating mutations in the epidermal growth factor receptor (EGFR) strongly associated with tumor progression and poor clinical outcomes. Among these mutations, the L858R mutation in exon 21 …

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Abstract 4599: Rationally designed allosteric EGFR degrader SC3499 (IN-207375) selectively eliminates mutant EGFR and overcomes osimertinib resistance in non-small cell lung cancer

Jihoon Choi, Jun Gyu Kim, Yu Jin Lee, Young Jun Park et autres

Abstract Epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) have demonstrated remarkable therapeutic efficacy in patients with non-small cell lung cancer (NSCLC) harboring activating EGFR mutations. However, acquired resistance often driven by secondary EGFR mutations remains a major clinical challenge. Although …

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Leveraging metabolic similarity in a 1H NMR database of medicinal plants to advance pharmacognostic insights

Sumin Seo, Özlem Erol, Hye Kyong Kim, Harald G. J. van Mil et autres

Natural products remain a central resource for drug discovery, and increasing evidence suggests that therapeutic effects often arise from the combined action of multiple constituents rather than single compounds. In this context, metabolomic profiling is essential for comparing complex plant chemical phenotypes, …

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Preclinical Pharmacological and Toxicological Evaluation of SB5794, a Novel Aryl Hydrocarbon Receptor Modulator on the Kynurenine–AhR Axis

Daewon Cha, Soo-Jung Choi, Hyunwoo Park, Dae Young Lee et autres

AhR antagonistic activity. In syngeneic tumor models, SB5794 significantly inhibited tumor growth, and its combination with anti-PD-1 therapy further enhanced antitumor efficacy. However, repeated-dose studies revealed dose-dependent histopathological changes in the gastrointestinal tract, liver, and immune organs. Collectively, these findings demonstrate that …

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Effects of white ginseng on reducing stress and tension by enhancing default mode network connectivity: A randomized, double-blinded placebo-controlled clinical trial

Youngeun Shim, Young‐Seob Lee, Yejin Kim, Seung Eun Lee et autres

Recent research has increasingly focused on the potential role of white ginseng ( Panax ginseng Meyer, PGC) in alleviating psychological conditions. This study aims to evaluate the efficacy and safety of PGC in reducing stress and tension over a 12-week period, employing …

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Anti‐Inflammatory and Antibacterial Properties of Curcuma longa Extract Against Helicobacter pylori

J.J. Kim, Kwan‐Woo Kim, Jin‐Kyu Jang, Myeong‐Jin Kim et autres

Helicobacter pylori is a Gram-negative, microaerophilic bacterium that colonizes the human stomach, causing gastritis, gastric ulcers, and gastric cancer. This study investigated the anti-Helicobacter and anti-inflammatory effects of Curcuma longa extract (CLE) as a potential treatment for H. pylori infection. Ultra-high performance …

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Abstract 5513: Discovery of SC2073, a potent and mutant selective EGFR degrader that overcomes 3rd generation EGFR inhibitors resistance in NSCLC

Ji‐Hoon Choi, Jun Gyu Kim, Ok Young Lee, Young Jun Park et autres

Abstract Epidermal growth factor receptor (EGFR) mutations, including the L858R activating mutation in exon 21, are major drivers of non-small cell lung cancer (NSCLC) and are targeted by EGFR tyrosine kinase inhibitors (TKIs). However, despite significant initial clinical benefits, resistance to EGFR …

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Whitening effect of panaxynol isolated from the leaves of Panax ginseng sprout

Dahye Yoon, Jin‐Kyu Jang, Woo Cheol Shin, Hyeon Seon Na et autres

Panaxynol was isolated from the leaves of Panax ginseng sprout.The chemical structure was determined based on spectroscopic methods, including 1D NMR ( 1 H, 13 C, DEPT), 2D NMR (gCOSY, gHMBC, HSQC), Optical rotation, and IR spectroscopy.Panaxynol inhibited potent melanogenesis (28.3%) in …

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DA‐7503, a novel tau aggregation inhibitor, ameliorates tau pathology and reduces CSF tau in transgenic mouse models of Alzheimer’s disease and primary tauopathies

Min Jung Lee, Song‐hyen Choi, Hyangsoo Lee, Eunjin Kim et autres

Abstract Background Elevation of cerebrospinal fluid (CSF) tau is a feature of Alzheimer’s disease (AD) and is being explored as a biomarker of AD and other tauopathies. The aim of this study was to elucidate the in vivo effects of DA‐7503, a …

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Metabolic differences in Zingiber officinale Roscoe by geographical origin determined via multiplatform metabolomics and method for simultaneous analysis of six phenolic compounds

Dahye Yoon, Bo‐Ram Choi, Hyoung‐Geun Kim, Dae Young Lee

Ginger, which is the rhizome of Zingiber officinale Roscoe, is widely distributed and consumed. The taste and aroma of ginger differ depending on its geographical origin. To distinguish the origin of ginger, ginger extracts from Korea, Peru, and China were analyzed using …

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Improvement of sleep disorders through the adenosine A receptor agonist effect of Phlomoides umbrosa Turczaninow root extract in pentobarbital-induced ICR mice

Joohyun Oh, Yoon-Young Han, Eun-Bi Kim, Ha‐Neul Jo et autres

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