Ildong (South Korea)

Genotoxicity, acute and subchronic oral toxicity assessments of postbiotics of Lacticaseibacillus rhamnosus IDCC 3201

Shin-Yae Choi, Dahae Hong, Jin Seok Moon, O‐Hyun Ban et autres

Postbiotics derived from lactic acid bacteria (LAB) have attracted growing interest as stable and potentially safer alternatives to probiotics for use in foods and health-related products. Comprehensive safety evaluation remains essential before their broader application. In this study, we assessed the safety …

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Efficacy and Safety of Bacillus coagulans IDCC 1201 for Sleep Improvement in Adults with Sleep Disturbance: A Randomized, Double-Blind, Placebo-Controlled Polysomnographic Study

Hayoung Kim, Jinho Lee, Won Yeong Bang, Han Bin Lee et autres

Background/Objectives: Sleep continuity is a key determinant of daytime functioning; however, accessible and well-tolerated interventions remain limited. We investigated whether Bacillus coagulans IDCC 1201 improves objective sleep continuity and subjective sleep quality in adults with sleep disturbance. Methods: In this 4-week, randomized, …

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Abstract 4599: Rationally designed allosteric EGFR degrader SC3499 (IN-207375) selectively eliminates mutant EGFR and overcomes osimertinib resistance in non-small cell lung cancer

Jihoon Choi, Jun Gyu Kim, Yu Jin Lee, Young Jun Park et autres

Abstract Epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) have demonstrated remarkable therapeutic efficacy in patients with non-small cell lung cancer (NSCLC) harboring activating EGFR mutations. However, acquired resistance often driven by secondary EGFR mutations remains a major clinical challenge. Although …

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Development and validation of a propidium monoazide-qPCR assay with matrix-matched calibration for selective quantification of viable Limosilactobacillus reuteri in multi-strain probiotic powders

Jinho Lee, Jin Seok Moon

Accurate enumeration of viable probiotic cells in commercial products is essential for quality control, label compliance, and product development. Conventional plate counting is labour-intensive and primarily quantifies culturable cells, whereas quantitative PCR (qPCR) is rapid, strain-specific, and detects DNA from both live …

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Randomized, Double-Blind, Placebo-Controlled Trial of ID-CBT5101, a Tyndallized Clostridium butyricum Postbiotic, in Adults with Mild-to-Moderate Knee Osteoarthritis

Han Bin Lee, Jinho Lee, Kyuho Jeong, Jungwoo Yang et autres

Osteoarthritis (OA) is a common cause of chronic pain and functional impairment in older adults.Evidence suggests a gut-joint axis, where gut dysbiosis and systemic low-grade inflammation may contribute to OA pathogenesis.Postbiotics, which are non-viable microbial products such as heat-killed bacteria, have been …

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Gut Microbiota Modulation by Lacticaseibacillus paracasei EFEL6501 Ameliorates Muscle Atrophy

Geum Na Pyeon, Hyunbin Seong, Jin Seok Moon, Nam Soo Han

Probiotics play a crucial role in promoting host health by modulating the composition of the gut microbiota through the production of their own bioactive metabolites.The aim of the study was to investigate the anti-atrophic effects of Lacticaseibacillus paracasei EFEL6501 (EFEL6501) in dexamethasone …

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Modulation of the Gut Microbiome and Metabolomes by Fermentation Using a Probiotic Complex in a Dysbiosis-Associated Fecal Model

Hayoung Kim, Hyeon Ji Jeon, Hye Min Jeong, Won Yeong Bang et autres

. Metabolomic profiling further revealed significant alterations in metabolite levels that may help alleviate gut dysbiosis-related symptoms. These included increases in 3-hydroxybutyric acid, ascorbic acid, cadaverine, L-hydroxyproline, and N-acetylornithine and decreases in lysine and 3-aminoalanine. Given the single-donor design and the use …

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Intention to use a health information platform in supportive housing for people with disabilities: An application of the UTAUT model

B. H. Kim, Hye Jin Nam, Haesun Lee, Han Nah Park et autres

Staff in supportive housing for people with disabilities face challenges in delivering effective health management, highlighting the need for a health information communication and management platform (referred to as "the platform"). This study aimed to identify factors influencing staff's intention to use …

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A systematic review of Photovoice studies on health-promoting behaviors among individuals with disabilities: Insights from the socio-ecological model

Hye Jin Nam, Han Nah Park, Sujin Lee, Gyeong A Kang et autres

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Protective effects of Limosilactobacillus fermentum EFEL6800 on muscle atrophy: insights from gut microbiota modulation and bioactive metabolite production

Geum Na Pyeon, Hyunbin Seong, Jin Seok Moon, Nam Soo Han

Pathological conditions such as muscle atrophy and sarcopenia are characterized by reductions in skeletal muscle mass and strength, leading to impaired physical function. This study investigates the protective effects of Limosilactobacillus fermentum EFEL6800 in dexamethasone (DEX)-induced C2C12 cells and murine model by …

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Folate Production by Streptococcus thermophilus IDCC 2201 and Its Impact on Human Gut Microbiota

Eoun Ho Nam, Minjee Lee, Donggyu Kim, Young Hoon Jung et autres

Probiotics have been extensively investigated as potential food supplements for human health benefits.Metabolites derived from probiotics are the primary factors that characterize each strain's functionality and play a crucial role in shaping their effects on the human host.In this study, we characterized …

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First‐In‐Human Dose Finding Study of Venadaparib ( IDX ‐1197), a Potent and Selective PARP Inhibitor, in Patients With Advanced Solid Tumors

Sung‐Bae Kim, Kyun‐Seop Bae, Jae‐Lyun Lee, Won Sik Lee et autres

BACKGROUND: Venadaparib, a novel poly (ADP-ribose) polymerase (PARP) inhibitor, has demonstrated high PARP-1/2 selectivity over other PARP family members and exhibited strong PARP-trapping activity, effectively inhibiting tumor growth in homologous recombination deficient (HRD) cancer in vitro and in vivo. METHODS: This phase …

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