Abstract 5513: Discovery of SC2073, a potent and mutant selective EGFR degrader that overcomes 3rd generation EGFR inhibitors resistance in NSCLC
Ji‐Hoon Choi, Jun Gyu Kim, Ok Young Lee, Young Jun Park et autres
Abstract Epidermal growth factor receptor (EGFR) mutations, including the L858R activating mutation in exon 21, are major drivers of non-small cell lung cancer (NSCLC) and are targeted by EGFR tyrosine kinase inhibitors (TKIs). However, despite significant initial clinical benefits, resistance to EGFR …
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Cancer Research