Matthew D. Estrada

Gene Regulatory Programs of NK Cells Show That NCAM1 (CD56) and KIRs Are Controlled by Genetically Polymorphic Distal Regulatory Elements

Mariam A. Salem, Aditi Varkey, Matthew D. Estrada, Kruthika Sharma et autres

ABSTRACT Owing to their immunoprotective properties, natural killer (NK) cells are critical for the innate immune response to pathogens, as well as a new wave of cancer immunotherapy that harnesses natural cytotoxicity. We sought to study the genetic and epigenetic drivers behind …

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Author response for "Gene regulatory programs of NK cells show that NCAM1 (CD56) and KIRs are controlled by genetically polymorphic distal regulatory elements"

Mariam A. Salem, Aditi Varkey, Matthew D. Estrada, Kruthika Sharma et autres

Author response for "Gene regulatory programs of NK cells show that NCAM1 (CD56) and KIRs are controlled by genetically polymorphic distal regulatory elements"

Mariam A. Salem, Aditi Varkey, Matthew D. Estrada, Kruthika Sharma et autres

Identification of Cardiac Glycosides as Novel Inhibitors of eIF4A1-Mediated Translation in Triple-Negative Breast Cancer Cells

Cory M. Howard, Matthew D. Estrada, David Terrero, Amit Kumar Tiwari et autres

The eukaryotic translation initiation factor 4F complex (eIF4F) is a potential chemotherapeutic target in triple-negative breast cancer (TNBC). This complex regulates cap-dependent translational initiation and consists of three core proteins: eIF4E, eIF4G, and eIF4A1. In this study, we focus on repositioning compounds …

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