J.E. Mcdonough

Integration of Multiomic and Multi-phenotypic Data Identifies Biological Pathways Associated with Physical Fitness

Azar Alizadeh, John F. Graf, Matthew J. Misner, Andrew Burns et autres

ABSTRACT Unraveling the complex associations between human phenotypes and molecular pathways can pave the way to improved health and performance, but faces a fundamental challenge: the measurable genes, proteins, and metabolites vastly outnumber the participants in even the largest studies, yielding spurious …

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The Potential Role of GPR87 in the Development of Pulmonary Fibrosis

Johad Khoury, Farida Ahangari, A. Justet, Thomas G. Adams et autres

Abstract Background: G-protein Coupled receptor 87 (GPR87), an orphan lysophosphatidic acid (LPA) receptor, was reported in idiopathic pulmonary fibrosis (IPF) airway basal cells. We have previously reported that GPR87 is highly expressed in IPF, mainly in airway basal and aberrant basaloid cells, …

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Abstract 3467: Delivery of CpG and GM-CSF in a novel silica-based scaffold leads to differentiation of AML blasts and T cell-dependent immunity in syngeneic AML tumor models

Fernanda Langellotto, J.E. Mcdonough, Benjamin T. Seiler, Brena Barra et autres

Abstract Background: Acute Myeloid Leukemia (AML) has poor prognosis, however, differentiation therapy results in a high cure rate for a subset of patients with acute promyelocytic leukemia. Prior preclinical studies using a cryogel-based “antigen free” system demonstrated complete remission in AML models …

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Centanafadine Sustained Release Is Efficacious in the Treatment of Adult ADHD Across Disease Severities

Andrew J. Cutler, Alan Zhang, Caroline Ward, J.E. Mcdonough et autres

Introduction Centanafadine (CTN) is a potential first-in-class norepinephrine/dopamine/serotonin triple reuptake inhibitor (NDSRI). The efficacy, safety, and tolerability of CTN sustained release (SR) for adults with ADHD was demonstrated in 2 pivotal phase 3 trials (Adler LA, et al. J Clin Psychopharmacol. 2022;42:429-39). …

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The Pulmonary Fibrosis Drug Connectome

Jane Flint, Prabin Sharma, T. Adams, A. Lepe et autres

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Cellular Ageing and Senescence Transcriptional Modules in the Aged Human Lung

Ruben De Man, J.E. Mcdonough, T. Adams, Xiting Yan et autres

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Morphometrics and Mucosal Immune Features in Lungs With End-stage Chronic Obstructive Pulmonary Disease

Charlotte de Fays, Hanne Beeckmans, Pieterjan Kerckhof, Vincent Geudens et autres

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Aberrant Basaloid Cells and Closely Connected Intermediate State Cells Are Involved in the Injury Repair Process of the Fibrotic Lungs in the Aftermath of Severe COVID-19

A. Balayev, T. Adams, A. Justet, Jonas C. Schupp et autres

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Spatial Transcriptomic Analysis Allow the Identification of Abnormal Airway Niches in the Fibrotic Lung

A. Justet, T. Adams, A. Balayev, T. Baernthaler et autres

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Online Cell Atlases Improve Interrogation of Lung Transcriptomic Data

Jane Flint, Prabin Sharma, Carlos Cosme, Nir Neumark et autres

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JAK-STAT pathway is upregulated in CLAD

Hanne Beeckmans, J.E. Mcdonough, Laurens De Sadeleer, Annelore Sacreas et autres

Background: Chronic lung allograft dysfunction (CLAD) is the major long-term complication after lung transplantation, clinically manifesting as 2 main phenotypes: bronchiolitis obliterans syndrome (BOS) and restrictive lung allograft syndrome (RAS). Janus kinases (JAKs) are intracellular signaling molecules, and play a role in …

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Deconvolution of Spatial Transcriptomic Allows to Predict the Spatial Location of Each Cell Type of Interest in the Fibrotic Lung

A. Justet, Thomas G. Adams, A. Balayev, Thomas Bärnthaler et autres

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