Yajun Qian

CD8⁺ Regulatory T Cells Shorten Neutrophil Lifespan to Reduce Hemorrhagic Transformation After Ischemic Stroke

Jianan Lü, Zhang Qia, Jiarui Chen, Huaming Li et autres

The neutrophil-to-lymphocyte ratio (NLR) is associated with unfavorable prognosis and hemorrhagic transformation (HT) in patients with ischemic stroke, yet the underlying mechanisms remain unclear. Using patient samples and a murine stroke model, we identified CD8⁺ regulatory T cells (CD8 Tregs) key regulators …

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Admission 25-Hydroxyvitamin D Deficiency Is Associated with Poor Outcomes in ICU Patients with Sepsis-Associated Encephalopathy (SAE)

Yajun Qian, Chen Qu, Hui Qi, Yan Xu

Background: Sepsis-associated encephalopathy (SAE) is a serious complication affecting septic patients and significantly increases mortality. Serum 25-hydroxyvitamin D (vitamin D) deficiency is prevalent in critical illness, but its relationship with SAE prognosis remains unclear. Methods: This retrospective cohort study enrolled SAE patients …

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Characteristics of T-lymphocyte subsets in patients with severe fever with thrombocytopenia syndrome complicated with invasive pulmonary aspergillosis: a retrospective study

Ying Xu, Yang Liu, Yajun Qian, Ning Liu et autres

Objectives: Immunosuppressed patients often acquire invasive pulmonary aspergillosis (IPA). In recent years, the incidence of patients with severe fever with thrombocytopenia syndrome (SFTS) complicated with IPA has increased. This study aimed to investigate the characteristics of the counts of T-lymphocyte subsets in …

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[The investigation of the mechanism underlying the impairment of the intestinal mucous barrier in severe hypertriglyceridemia acute pancreatitis].

Jialiang Du, Yajun Qian, Yali Xu, Xiancheng Chen et autres

OBJECTIVE: To investigate the structural and functional alterations of intestinal goblet cells and the mucus barrier in rats with hypertriglyceridemia acute pancreatitis (HTG-AP), and to evaluate the potential mechanism involved in the progression to severe HTG-AP. METHODS: Twenty-four specific pathogen-free male Sprague-Dawley …

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Establishment and validation of a nomogram for predicting severe fever with thrombocytopenia syndrome complicated by invasive pulmonary aspergillosis

Ruyu Yan, Ke Jiang Cao, Taishun Li, Hui Qi et autres

OBJECTIVES: Severe fever with thrombocytopenia syndrome (SFTS) complicated by invasive pulmonary aspergillosis (IPA) is associated with high incidence and mortality. This study aimed to develop a clinically practical predictive model for assessing the risk of IPA in SFTS patients, thereby enabling early …

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Influence of the Co-infection of Other Pathogens on the Clinical Characteristics and Prognosis of Severe H1N1 Influenza Pneumonia

Jialiang Du, Yajun Qian, Yan Wang, Ying Xu et autres

Abstract Objective: To compare the clinical characteristics and prognostic outcomes of patients with severe H1N1 influenza pneumonia, with and without concurrent infections, while also identifying early warning indicators. Methodology: We included 47 patients diagnosed with severe H1N1 influenza pneumonia, extracted their data …

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Corrigendum to “Refeeding hypophosphatemia is a common cause of delirium in critically ill patients: A retrospective study” [The American Journal of the Medical Sciences 369 (2025) 62–70]

Ying Xü, Yajun Qian, Pei Liang, Ning Liu et autres

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Advances in Research on Meningeal Lymphatic Vessels in Central Nervous System Diseases

Huimin Shen, Bingrui Zhu, Yajun Qian, Jun Song Mo

Meningeal lymphatic vessels (mLVs), located around the dural sinuses, are considered significant participants in cerebrospinal fluid (CSF) circulation. Meningeal lymphatic vessels not only drain fluids and metabolic waste from the brain into deep cervical lymph nodes (dCLNs) but also transport immune cells …

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Multifaceted role of thrombin in subarachnoid hemorrhage: Focusing on cerebrospinal fluid circulation disorder

Yajun Qian, Junjie Wang, Jiarui Chen, Huimin Shen et autres

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Refeeding hypophosphatemia is a common cause of delirium in critically ill patients: A retrospective study

Ying Xü, Yajun Qian, Pei Liang, Ning Liu et autres

INTRODUCTION: The purpose was to explore the correlation between refeeding hypophosphatemia and delirium and analyze the related factors in critically ill patients. METHODS: We conducted a retrospective review of critically ill patients admitted to Nanjing Drum Tower Hospital between September 2019 and …

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[Clinical study on the predictive value of regional cerebral oxygen saturation for the occurrence of sepsis-associated encephalopathy].

Yajun Qian, Jing Li, Danjiang Dong, Qin Gu

OBJECTIVE: ) for the occurrence of sepsis-associated encephalopathy (SAE). METHODS: on SAE during ICU stay. RESULTS: = 0.640 as the diagnostic threshold, the sensitivity was 73.4%, the specificity was 80.0%. Compared with the non-SAE group, the length of ICU stay and hospital …

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Pulmonary artery flotation catheter (PAFC) combined with pump-controlled retrograde trial off (PCRTO) as a trial for weaning VA-ECMO patients: A retrospective study

Ying Chun Xu, Ning Liu, Danjiang Dong, Jian Tang et autres

Objectives Pump-controlled retrograde trial off (PCRTO) has been recently proposed as an effective and safe VA-ECMO weaning method. However, reports of haemodynamic monitoring during PCRTO are rare. Therefore, the purpose of this study was to investigate the changes in the left and …

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