Jiarui Chen

A nomogram integrating postoperative pathology and systemic inflammation for predicting early recurrence after conversion surgery in initially unresectable intrahepatic cholangiocarcinoma

Lizhao Yu, Yanpeng Li, Jiarui Chen, Aixian Zhang et autres

About 70% of intrahepatic cholangiocarcinoma (ICC) patients have advanced, unresectable disease at first diagnosis. Preoperative conversion therapy may enable subsequent curative-intent hepatectomy in selected patients, but early recurrence (ER) may compromise the survival benefit achieved by conversion surgery. Currently, studies on ER …

cn (code pays fourni par la source)

CD8⁺ Regulatory T Cells Shorten Neutrophil Lifespan to Reduce Hemorrhagic Transformation After Ischemic Stroke

Jianan Lü, Zhang Qia, Jiarui Chen, Huaming Li et autres

The neutrophil-to-lymphocyte ratio (NLR) is associated with unfavorable prognosis and hemorrhagic transformation (HT) in patients with ischemic stroke, yet the underlying mechanisms remain unclear. Using patient samples and a murine stroke model, we identified CD8⁺ regulatory T cells (CD8 Tregs) key regulators …

cn (code pays fourni par la source)

Development of a Comprehensive Peri-anesthetic Bundle of Postoperative Delirium Interventions for Thoracic Patients: a Delphi Method Consensus Study

Rui Wang, Min Xu, Yali Wu, Jiarui Chen et autres

cn (code pays fourni par la source)

Physiology-Based Pharmacokinetic Modeling of Ropivacaine After External Oblique Intercostal Plane Block in Open Liver Surgery Patients

Jiali Tang, Jiarui Chen, Ning Sheng, Bowen Zheng et autres

Background/Objectives: The external oblique intercostal (EOI) plane block shows promise for postoperative analgesia after open liver surgery. Pharmacokinetic profiles of ropivacaine after EOI plane block remain unclear. Meanwhile the pharmacokinetic data informs safety assessment, guides post-block monitoring duration, and predicts blockade duration. …

cn (code pays fourni par la source)

Bovine viral diarrhea virus suppresses type I IFN production by inducing MAVS degradation via autophagy mediated by the ROS-endoplasmic reticulum stress axis

Jing Wang, Jiangfei Zhou, Yixin Wang, Wenlu Fan et autres

Bovine viral diarrhea virus (BVDV) is a major animal pathogen with a broad host range, causing gastrointestinal, respiratory, and reproductive diseases in cattle worldwide. BVDV exists as two biotypes: cytopathic (cp) and non-cytopathic (ncp). Although both cpBVDV and ncpBVDV have developed sophisticated …

cn, kn (code pays fourni par la source)

The Efficacy of a Multidisciplinary Perianesthetic Management Bundle for Alleviating Delirium After Thoracic Surgery: A Randomized Clinical Trial

Min Xu, Yali Wu, Rui Wang, Chuan Luo et autres

cn (code pays fourni par la source)

Multi‐Omics Dissection of TIMP1 in Monocytes/Macrophages Reveals Pathogenic Mechanisms and Therapeutic Opportunities in Ankylosing Spondylitis

Jiarui Chen, Chengqian Huang, Jiang Xue, Zhongxian Zhou et autres

The pathogenesis of ankylosing spondylitis (AS) remains unclear, and its treatment poses significant challenges. This study aims to elucidate the underlying mechanisms of AS and explore potential therapeutic targets. We conducted a comprehensive multi-omics analysis, integrating proteomics, miRNA profiling, and single-cell sequencing …

cn (code pays fourni par la source)

Cytopathic bovine viral diarrhea virus-induced NLRP3 inflammasome activation triggers GSDMD-mediated pyroptosis, amplifying the inflammatory response

Xin Sheng Yao, Yuan Li, Jing Wang, Zheyi Liu et autres

cn (code pays fourni par la source)

Research on Illegal Building Detection Method Based on Improved YOLOv5s Model

Jiahao Huang, Xingrui Yun, Jiarui Chen, Yu‐Shun Yang et autres

To address the issues of long cycles, information lag, and potential disputes in traditional manual detection of illegal buildings, this paper proposes a UAV-based intelligent recognition system utilizing deep learning. The system, centered on an enhanced YOLOv5s model, employs UAV aerial photography …

cn (code pays fourni par la source)

Development and Validation of a Machine Learning‐Based Online Prognostic Model for Cervical Spondylosis Patients After Anterior Cervical Discectomy and Fusion: A Multicenter Study

Sitan Feng, Shengsheng Huang, Zhongxian Zhou, Bin Zhang et autres

Background: Cervical spondylosis (CS) is a degenerative condition often requiring surgical intervention, such as anterior cervical discectomy and fusion (ACDF), to alleviate symptoms. However, postoperative outcomes can vary significantly. This study aimed to develop and validate a predictive model for 1-year outcomes …

cn (code pays fourni par la source)

The Impact of Screw Density on the Outcomes of Adolescent Idiopathic Scoliosis Correction Surgery: A Multicenter Retrospective Study

Zhaojun Lu, Chong Liu, Jiarui Chen, Jiang Xue et autres

Background To evaluate the efficacy of low screw density constructs versus high screw density constructs in adolescent idiopathic scoliosis (AIS) surgery.Methods Data were collected from AIS patients who underwent pedicle screw fixation surgery at two medical centers. Patients were stratified into low …

cn (code pays fourni par la source)

[Explanation and interpretation of blood transfusion provisions for children undergoing cardiac surgery in the national health standard "Guideline for pediatric transfusion"].

Rong Huang, Qingnan He, Mingyan Hei, Minghua Yang et autres

To guide clinical blood transfusion practices in pediatric patients, the National Health Commission has issued the health standard "Guideline for pediatric transfusion" (WS/T 795-2022). Children undergoing cardiac surgery are at high risk of bleeding, and the causes of perioperative anemia and coagulation …

cn (code pays fourni par la source)