Vı́tězslav Kolek

Deciphering the genetic tapestry: Insights into sarcoidosis across diverse populations with the MESARGEN Consortium

Natalia V. Rivera, Olga D. Chuquimia, Nathan P. Pezant, Martin Kerick et autres

Prognostic impact of PD-1 and PD-L1 expression in malignant pleural mesothelioma: an international multicenter study

Luka Brčić, Thomas Klikovits, Zsolt Megyesfalvi, Berta O. Mosleh et autres

Background: Programmed cell death 1/programmed death ligand 1 (PD-1/PD-L1) immune-checkpoint blockade is a promising new therapeutic strategy in cancer. However, expression patterns and prognostic significance of PD-L1 and PD-1 are still controversial in human malignant pleural mesothelioma (MPM).Methods: Formalin-fixed paraffin-embedded (FFPE) tumor …

at, hu, si, hr, cz, de (code pays fourni par la source)

Nozokomiální pneumonie – antibiotická léčba

Milan Kolář, Jiří Beneš, Vı́tězslav Kolek, Helena Žemličková et autres

Nozokomialni pneumonie (HAP – Hospital Acquired Pneumonia a VAP – Ventilator Associated Pneumonia) je druhou nejcastějsi nozokomialni infekci, a u pacientů na jednotkach intenzivni pece dokonce nejcastějsi. Z hlediska morbidity, mortality a ekonomických nakladů představuji HAP/VAP nejdůležitějsi skupinu nozokomialnich infekci; a při …

Dabrafenib monotherapy in BRAF+ non-small cell lung cancer – our experience

Ondřej Fischer, Vı́tězslav Kolek, Denisa Rozsívalová, Tomáš Tichý et autres

BACKGROUND: Activating BRAF mutations result in constitutive activation of the MAP kinase signaling cascade, stimulating cell proliferation. BRAF mutations are typical for malignant melanoma, but occur less frequently in other tumors, including in 1-2% cases of non-small cell lung cancer (NSCLC) [1,2]. …

Durvalumab, with or without tremelimumab, plus platinum–etoposide versus platinum–etoposide alone in first-line treatment of extensive-stage small-cell lung cancer (CASPIAN): updated results from a randomised, controlled, open-label, phase 3 trial

Jonathan Wade Goldman, Mikhail Vladimirovich Dvorkin, Yuanbin Chen, Niels Reinmuth et autres

us, ru, de, jp, at, tr, kr, it, ua, es, cz, pl, hu, bg, gb (code pays fourni par la source)

Giant lung metastasis of NRAS-mutant melanoma in a 24-year-old patient with a history of BRAF-mutant conventional melanoma harboring Spitzoid morphology: a case report

J Vachtenheim, Roman Kodet, Ondřej Fischer, Vı́tězslav Kolek et autres

BACKGROUND: Spitzoid melanocytic lesions represent a heterogeneous group of proliferations with ambiguous and overlapping terminology. The exact distinction of a Spitz nevus from a Spitzoid melanoma can be very difficult or, in some cases, impossible. Among the Spitzoid lesions, there is a …

cz (code pays fourni par la source)

Recognizing and treating sarcoidosis

Monika Žůrková, Vladimíra Lošťáková, Petr Jakubec, Vı́tězslav Kolek et autres

Sarkoidóza je multisystémové granulomatózní onemocnění neznámé etiologie, které obvykle postihuje jedince středního a staršího věku, nejčastěji ženy starší 40 let. Příznaky, se kterými se může setkat lékař prvního kontaktu, mohou být velmi nespecifické. Nejtypičtější potíže se objevují u akutní formy nemoci, tzv. …

cz (code pays fourni par la source)

Epidermal growth factor receptor (EGFR) gene mutation testing prior to tyrosine kinase inhibitors (TKI) treatment – prospective data from the Czech TULUNG registry

Jana Skřičková, Petra Májková, Magda Bařinová, Monika Bratová et autres

Study evaluated the frequency of individual mutations before the start of the 1st and 2nd generation TKI treatment, and determined in what material the mutations were identified and what methods led to obtainig the best material. The TULUNG registry, containing data of …

cz (code pays fourni par la source)

Genetic control of CCL24, POR, and IL23R contributes to the pathogenesis of sarcoidosis

Akira Meguro, Mami Ishihara, Martin Petřek, Ken Yamamoto et autres

Abstract Sarcoidosis is a genetically complex systemic inflammatory disease that affects multiple organs. We present a GWAS of a Japanese cohort (700 sarcoidosis cases and 886 controls) with replication in independent samples from Japan (931 cases and 1,042 controls) and the Czech …

jp, cz, us, fr (code pays fourni par la source)

Prognostic value of tumor-infiltrating lymphocytes (TILs) and their association with PD-L1 expression and DNA repair protein RAD51 in patients with resected non-small cell lung carcinoma

Mariam A. Gachechiladze, Jozef Škarda, Daniela Škanderová, Ivo Überall et autres

cz, ch (code pays fourni par la source)

Chronotropic incompetence could negatively influence post-operative risk assessment in patients before lung cancer surgery

Milan Sova, Samuel Genzor, Amjad Ghazal Asswad, Vı́tězslav Kolek

Background: Cardiopulmonary exercise testing (CPET) is a standard part of preoperative evaluation in patients before lung surgical resection. According to current guidelines the risk of such a procedure is estimated according to maximum oxygen consumption (VO2max). Chronotropic incompetence (CI) is a prevalent …

cz, gb (code pays fourni par la source)

Efficacy and analgesic use during the therapy of iatrogenic pneumothorax using Pleuralvent™ and Chest Tube (ASPIRATE): A randomised controlled trial protocol

Milan Sova, Martin Poruba, Samuel Genzor, Petr Jakubec et autres

BACKGROUND: Iatrogenic pneumothorax is a common complication of various diagnostic and therapeutic procedures such as transbronchial lung biopsies. The classical mode of treatment is chest tube insertion. Pneumothorax devices are now available on the market but there is a dearth of data …

cz, gb (code pays fourni par la source)