Tomáš Tichý

Tacrolimus Dose Reduction as an Effective Therapeutic Approach to the Patients with Active BK Polyomavirus Replication and Nephrotoxicity

Ester Kurašová, Tomáš Tichý, Pavel Sauer, Kamil Žamboch et autres

BK polyomavirus nephropathy (BKPyV-nephropathy) leads to functional failure of kidney grafts in the early post-transplant period. The intensity of immunosuppressive therapy plays a significant role in the activation of BK polyomavirus (BKPyV) replication. We prospectively evaluated 457 per-protocol biopsies of kidney grafts …

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Visceral Leishmaniasis as a cause of fever of unknown origin: a unique disease pattern shown on [18F]-FDG PET/CT

Gregor Horňák, Peter Turcsányi, Vojtěch Látal, František Stejskal et autres

This case report describes a 69-year-old man with visceral Leishmaniasis. The progressively worsening clinical condition of the patient, combined with nonspecific imaging findings and laboratory results, led to diagnostic difficulties in identifying this rarely encountered infectious disease in the Czech Republic. The …

Primary multifocal extramedullary multiple myeloma with a rare cytogentic abnormality

Vojtěch Látal, Tomáš Pika, Miroslava Mlynárčiková, Jana Balcárková et autres

Neoadjuvant nivolumab and cabozantinib in advanced renal cell carcinoma in a horseshoe kidney – how to achieve a safe and radical resection? a case report and review of the literature

Anežka Zemánková, Hana Študentová, A. Kopová, Tomáš Tichý et autres

Introduction: Neoadjuvant nivolumab and cabozantinib in locally advanced renal cell carcinoma in a horseshoe kidney is a novel therapeutic approach in the preoperative setting. Methods: We report a case of a 52-year old male who presented with a large inoperable tumor of …

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The role of fluorescence in situ hybridization in primary diagnosis of distal biliary strictures

Vincent Zoundjiekpon, Přemysl Falt, Jana Zapletalová, Daniela Kurfürstová et autres

Summary: Background and aim: Primary diagnosis of the distal biliary stricture can be sometime difficult. Brush cytology (BC) is known to have low diagnostic sensitivity in these cases. Fluorescence in situ hybridization (FISH) has been reported as a useful adjunctive test in …

P8.122: Tacrolimus Dose Reduction as an Effective Therapeutic Approach to the Patients With Active BK Virus Replication And Nephrotoxicity

Karel Krejčí, Tomáš Tichý, Pavel Sauer, Josef Zadražil et autres

Background: BK viral nephropathy (BKVN) affects a significant proportion of kidney grafts in the early post-transplant period and often leads to functional failure of these grafts. The intensity of immunosuppressive therapy plays a significant role in the activation of BK viral (BKV) …

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Antineutrophil Cytoplasmic Autoantibody-Associated Glomerulonephritis as a Complication of Home Parenteral Nutrition

Hana Flögelová, Eva Karásková, Kateřina Bouchalová, Marie Rohanova et autres

Patients on long-term home parenteral nutrition (HPN) occasionally develop glomerulonephritis due to chronic central venous catheter (CVC)-related infection. Most previously reported cases were membranoproliferative glomerulonephritis (MPGN). This is a case report of a 16-year-old girl receiving HPN for short bowel syndrome. After …

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Current Status, Prevention and Treatment of BK Virus Nephropathy

Ester Kurašová, Jakub Štěpán, Karel Krejčí, František Mrázek et autres

All renal transplant recipients should undergo a regular screening for BK viral (BKV) viremia. Gradual reduction of immunosuppression is recommended in patients with persistent plasma BKV viremia for 3 weeks after the first detection, reflecting the presence of probable or suspected BKV-associated …

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Dabrafenib monotherapy in BRAF+ non-small cell lung cancer – our experience

Ondřej Fischer, Vı́tězslav Kolek, Denisa Rozsívalová, Tomáš Tichý et autres

BACKGROUND: Activating BRAF mutations result in constitutive activation of the MAP kinase signaling cascade, stimulating cell proliferation. BRAF mutations are typical for malignant melanoma, but occur less frequently in other tumors, including in 1-2% cases of non-small cell lung cancer (NSCLC) [1,2]. …

Nephrotoxicity of calcineurin inhibitors as a risk factor for BK polyomavirus replication after kidney transplantation

Karel Krejčí, Tomáš Tichý, Jana Bednaříková, Margita Bartková et autres

BK polyomavirus-associated nephropathy (PyVAN) is responsible for a significant percentage of transplanted kidneys prematurely terminating their function. Its occurrence is closely related to the intensity of immunosuppressive therapy. In a group of 161 newly transplanted patients, we prospectively evaluated 457 protocol renal …

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Motorized spiral enteroscopy – our first experience

Přemysl Falt, Tomáš Tichý, Ondřej Urban

P1759NEPHROTOXICITY OF CALCINEURIN INHIBITORS AS A RISK FACTOR FOR BK VIRUS REPLICATION AFTER KIDNEY TRANSPLANTATION

Karel Krejčí, Tomáš Tichý, Jana Bednaříková, Margita Bartková et autres

Abstract Background and Aims BK virus nephropathy (BKVN) represents a serious complication of kidney transplantation and is responsible for significant percentage of transplanted kidneys prematurely terminating their function. Its occurrence is considered a complication of immunosuppressive therapy and is closely related to …

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