John J. O’Neil

Selective impact on regulatory T cells with sustained functional phenotypes by the interleukin-2 mutein VIS171 in a nonhuman primate model

Davide Schiliró, Matt Tunbridge, Nolan J. Brown, Joshua Lopez et autres

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PRECLINICAL EVALUATION OF A MRGX2 TARGETING CYTAC FOR DEPLETING TISSUE-RESIDENT MAST CELLS 8224

Josephine Duvall, John J. O’Neil, Stephanie M. Wiltzius, Marco A. S. Baptista et autres

IBA1 EXPRESSION IN THE HIPPOCAMPUS OF APOLIPOPROTEIN EPSILON 4 SALT-TREATED MICE

Chloe’ Major, Syed J. Khundmiri, John J. O’Neil

Abstract Alzheimer’s disease (AD) is a progressive neurodegenerative disorder characterized by a decline in cognitive abilities, memory loss, and heightened neuroinflammation. The presence of the APOE4 allele is the most significant genetic risk factor for AD, known to accelerate the onset and …

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Kidney versus Islet Allograft Survival after Induction of Mixed Chimerism with Combined Donor Bone Marrow Transplantation

Tetsu Oura, Dicken S.C. Ko, Svjetlan Boskovic, John J. O’Neil et autres

We have previously reported successful induction of transient mixed chimerism and long-term acceptance of renal allografts in MHC mismatched nonhuman primates. In this study, we attempted to extend this tolerance induction approach to islet allografts. A total of eight recipients underwent MHC …

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Enrichment of human embryonic stem cell-derived NKX6.1-expressing pancreatic progenitor cells accelerates the maturation of insulin-secreting cells in vivo

Alireza Rezania, Jennifer E. Bruin, Jean Xu, Kavitha Narayan et autres

Human embryonic stem cells (hESCs) are considered a potential alternative to cadaveric islets as a source of transplantable cells for treating patients with diabetes. We previously described a differentiation protocol to generate pancreatic progenitor cells from hESCs, composed of mainly pancreatic endoderm …

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Maturation and function of human embryonic stem cell-derived pancreatic progenitors in macroencapsulation devices following transplant into mice

Jennifer E. Bruin, Alireza Rezania, Jean Xu, Kavitha Narayan et autres

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Maturation of Human Embryonic Stem Cell–Derived Pancreatic Progenitors Into Functional Islets Capable of Treating Pre-existing Diabetes in Mice

Alireza Rezania, Jennifer E. Bruin, Michael Riedel, Majid Mojibian et autres

Diabetes is a chronic debilitating disease that results from insufficient production of insulin from pancreatic β-cells. Islet cell replacement can effectively treat diabetes but is currently severely limited by the reliance upon cadaveric donor tissue. We have developed a protocol to efficiently …

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Quantitative analysis of cell composition and purity of human pancreatic islet preparations

Anna Pisania, Gordon C. Weir, John J. O’Neil, Abdulkadir Omer et autres

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Discovery of Novel and Potent Leukotriene B4Receptor Antagonists. Part 1

Robert A. Goodnow, Alexandra Hicks, Achyutharao Sidduri, Agnieszka Kowalczyk et autres

The inhibition of LTB(4) binding to and activation of G-protein-coupled receptors BLT1 and BLT2 is the premise of a treatment for several inflammatory diseases. In a lead optimization effort starting with the leukotriene B(4) (LTB(4)) receptor antagonist (2), members of a series …

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Effects of LTB4 receptor antagonism on pulmonary inflammation in rodents and non-human primates

Alexandra Hicks, Robert A. Goodnow, Gary Cavallo, Shahid Tannu et autres

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Long-Term Survival of Nonhuman Primate Islets Implanted in an Omental Pouch on a Biodegradable Scaffold

D.M. Bermana, John J. O’Neil, Lane Claire Katherine Coffey, Philippe Chaffanjon et autres

The aim of this study was to test whether an omental pouch can be used as an alternative site for islet implantation in diabetic monkeys. Here we report the successful engraftment of islets in diabetic cynomolgus monkeys when loaded on a synthetic …

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The Use of an Approved Biodegradable Polymer Scaffold as a Solid Support System for Improvement of Islet Engraftment

Tatsuya Kin, John J. O’Neil, Rena Pawlick, Gregory S. Korbutt et autres

The aim of this study was to investigate whether the use of a medically approved biodegradable scaffold as a solid support system would enhance graft survival following transplantation into the omental pouch in a preclinical large animal model. Six beagle dogs underwent …

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