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Eleanor D. Lederer, Syed J. Khundmiri
Disorders of phosphate homeostasis are common but difficult to treat. The major organ systems responsible for phosphate homeostasis are the intestine, bone, kidney, and parathyroid gland. Overall, kidney handling of phosphate is the major regulator of both serum phosphate levels and overall …
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Samina Salim, Mohammad Asghar, Syed J. Khundmiri, Farah Khan et autres
The study aimed to compare the effects of a diet rich in carbohydrates or fat on rat kidneys which play important role in the maintenance of body fluid volume., composition and pH by its absorptive functions.Rats were fed with a high carbohydrate …
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Shaza Khan, Lihe Chen, Chung‐Lin Chou, Syed J. Khundmiri et autres
knockout mouse line that will be shared with the research community and is likely to be useful for further study of the regulation of water balance and polycystic kidney disease, as well as neural, vascular, and metabolic roles of vasopressin.
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Muhammad Ali Syed, Zaria Opera, Gleice Kelli Silva-Cardoso, Prosper N’Gouemo et autres
Alcohol has been demonstrated to disrupt electrolyte balance and hemodynamics. However, there is a lack of findings displaying cohesive changes at the cellular level. Many cellular functions depend upon maintaining the homeostatic balance of ions and water, a primary responsibility of the …
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Zaria Opara, Ali H. Ahmed, Gerald Mathelier, Jahn N. O’Neil et autres
Introduction: Increasing studies suggest that high blood pressure is a risk factor for the development of Alzheimer’s Disease (AD). Studies have failed to look at differing etiologies of hypertension in the development of AD, specifically age-dependent salt-sensitive hypertension. Salt-sensitive hypertension is essential …
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Clifton Enlers, Laila A. Muhammad, Paola Correa-Alfonzo, Janine M. Ziermann et autres
Adult mammalian kidney is derived from the metanephros (nephrons) and mesonephros (collecting system). Several transcription factors such as PAX2, PAX8, CK7, and WT1 are known to regulate the development of kidneys. Mutations in an oncogenic protein p63, a cause of Ectrodactyly-ectodermal dysplasia-clefting …
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Chloe’ Major, Syed J. Khundmiri, John J. O’Neil
Abstract Alzheimer’s disease (AD) is a progressive neurodegenerative disorder characterized by a decline in cognitive abilities, memory loss, and heightened neuroinflammation. The presence of the APOE4 allele is the most significant genetic risk factor for AD, known to accelerate the onset and …
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Anish J. Jain, Hyun Jun Jung, Joseph I Aubee, Jahn N. O’Neil et autres
MicroRNAs (miRNAs) play important roles in the regulation of cellular function and fate via post-transcriptional regulation of gene expression. Although several miRNAs are associated with physiological processes and kidney diseases, not much is known about changes in miRNAs in aging kidneys. We …
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Dexter Lee, Syed J. Khundmiri, Minsol Kim, Moshe Levi et autres
SGLT2i has been shown to be protective of renal function and health in type 2 diabetes by unclear means. Recently we reported that empagliflozin (EMPA) treatment of mice on a high-fat diet (HFD) led to marked changes in the renal cortical lipidome, …
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Shaza Khan, Lihe Chen, Syed J. Khundmiri, Chung‐Lin Chou et autres
Background: Arginine vasopressin (AVP) is a peptide hormone coded by the Avp gene, synthesized in the hypothalamus and secreted by the posterior pituitary. Dysregulation of AVP secretion contributes to a variety of human diseases. Previous studies of functional roles of AVP have …
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Shaza Khan, Viswanathan Raghuram, Lihe Chen, Chung‐Lin Chou et autres
Vasopressin is a key hormone that regulates the function of the collecting duct of the kidney. ERK1 and ERK2 are enzymes that play key roles in physiological regulation in all cells. The authors used collecting duct cell cultures to investigate the effects …
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Shaza Khan, Lihe Chen, Syed J. Khundmiri, Mark A. Knepper
Background: Arginine vasopressin (AVP) is a peptide hormone coded by the Avp gene, synthesized in the hypothalamus and secreted by the posterior pituitary. Dysregulation of AVP secretion contributes to a variety of human diseases. Previous studies of functional roles of AVP have …
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