Lane Claire Katherine Coffey

Experimental approaches to the prevention of islet rejection

Norma S. Kenyon, Lane Claire Katherine Coffey

Chapter 21 focuses on experimental studies of allogeneic islet cell transplantation, with an emphasis on recent advances in the prevention of rejection, as exemplified by studies in rodents and nonhuman primates (NHP).

Immune Cell Populations in Nonhuman Primate Islets

Lane Claire Katherine Coffey, Dora M. Berman, Melissa A. Willman, Norma S. Kenyon

Islet transplantation is a promising cellular therapy for the treatment of type 1 diabetes (T1D). The immunogenicity of isolated islets has been of interest to the transplant community for many years, as upon transplantation, islets are damaged or destroyed through specific and …

us (code pays fourni par la source)

Immune cells, inflammatory molecules, and CD40 in nonhuman primate islets of Langerhans

Lane Claire Katherine Coffey

Long-Term Survival of Nonhuman Primate Islets Implanted in an Omental Pouch on a Biodegradable Scaffold

D.M. Bermana, John J. O’Neil, Lane Claire Katherine Coffey, Philippe Chaffanjon et autres

The aim of this study was to test whether an omental pouch can be used as an alternative site for islet implantation in diabetic monkeys. Here we report the successful engraftment of islets in diabetic cynomolgus monkeys when loaded on a synthetic …

fr, us (code pays fourni par la source)

CD40–CD40 Ligand Interaction Activates Proinflammatory Pathways in Pancreatic Islets

Florencia María Barbé‐Tuana, Dagmar Klein, Hirohito Ichii, Dora M. Berman et autres

Pancreatic islet transplantation is becoming an alternative to insulin therapy in patients suffering from brittle type 1 diabetes. A major obstacle to the procedure is the early graft loss caused by nonspecific inflammation at the site of implantation. We recently discovered that …

us (code pays fourni par la source)