Jill M. Harper

The synthesis of OspD3 (ShET2) inShigella flexneriis independent of OspC1

Christina S. Faherty, Tao Wu, Carolyn R. Morris, Christen L. Grassel et autres

Shigella flexneri is a Gram-negative pathogen that invades the colonic epithelium and causes millions of cases of watery diarrhea or bacillary dysentery predominately in children under the age of 5 years in developing countries. The effector Shigella enterotoxin 2 (ShET2), or OspD3, …

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Mo1941 Further Characterization of the Shigella Flexneri Effector OspD3 (ShET2) Reveals A Unique Expression Profile That Does Not Require OspC1

Christina S. Faherty, Tao Wu, Carolyn R. Morris, Christen L. Grassel et autres

Correction: Chromosomal and Plasmid-Encoded Factors of Shigella flexneri Induce Secretogenic Activity Ex Vivo

Christina S. Faherty, Jill M. Harper, Terez Shea‐Donohue, Eileen M. Barry et autres

The name of the first author was missing a middle initial. The correct name is: Christina S. Faherty

Chromosomal and Plasmid-Encoded Factors of Shigella flexneri Induce Secretogenic Activity Ex Vivo

Christina S. Faherty, Jill M. Harper, Terez Shea‐Donohue, Eileen M. Barry et autres

Shigella flexneri is a Gram-negative, facultative intracellular pathogen that causes millions of cases of watery or bloody diarrhea annually, resulting in significant global mortality. Watery diarrhea is thought to arise in the jejunum, and subsequent bloody diarrhea occurs as a result of …

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Induction of Increased Permeability of Polarized Enterocyte Monolayers by Enterotoxigenic Escherichia coli Heat-Labile Enterotoxin

Roderick B. Kreisberg, Jill M. Harper, Maura C. Strauman, Mark E. Marohn et autres

Enterotoxigenic Escherichia coli (ETEC) is a common cause of acute diarrhea in resource-poor settings. We report that some ETEC strains elicit a reduction in trans-epithelial electrical resistance (TER) in polarized T84 epithelial cell monolayers. The effect was irreversible up to 48 hours …

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Enteroaggregative Escherichia coli Disrupts Epithelial Cell Tight Junctions

Maura C. Strauman, Jill M. Harper, Susan M. Harrington, Erik Juncker Boll et autres

Enteroaggregative Escherichia coli (EAEC) is responsible for inflammatory diarrhea in diverse populations, but its mechanisms of pathogenesis have not been fully elucidated. We have used a previously characterized polarized intestinal T84 cell model to investigate the effects of infection with EAEC strain …

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205 Increased IFN-alpha expression in circulating plasmacytoid dendritic cells of HIV-1 infected patients despite selective loss

Clara Lehmann, Dirk Taubert, Jill M. Harper, Norma Jung et autres

Background: The role of plasmacytoid dendritic cells (PDC) and interferon alpha (IFNγ) in HIV-1 infection is still unclear. On one hand, HIV-1 disease is associated with a progressive decline of pDC, which display reduced ability to produce IFNγ after in vitro challenge. …

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An In Vitro System to Model the Establishment and Reactivation of HIV-1 Latency

Alessandra Marini, Jill M. Harper, Fabio Romerio

HIV-1 establishes latency primarily by infecting activated CD4(+) T cells that later return to quiescence as memory cells. Latency allows HIV-1 to evade immune responses and to persist during antiretroviral therapy, which represents an important problem in clinical practice. The lack of …

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Increased Interferon Alpha Expression in Circulating Plasmacytoid Dendritic Cells of HIV-1-Infected Patients

Clara Lehmann, Jill M. Harper, Dirk Taubert, Pia Hartmann et autres

BACKGROUND: The role of plasmacytoid dendritic cells (pDC) and interferon alpha (IFN alpha) in HIV-1 infection is still unclear. On one hand, HIV-1 disease is associated with a progressive decline of pDC, which displays reduced ability to produce IFN alpha after in …

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A transient forward‐targeting element for microneme‐regulated secretion in Toxoplasma gondii

Susannah D. Brydges, Jill M. Harper, Fabiola Parussini, Isabelle Coppens et autres

BACKGROUND INFORMATION: Accurate sorting of proteins to the three types of secretory granules in Toxoplasma gondii is crucial for successful cell invasion by this obligate intracellular parasite. As in other eukaryotic systems, propeptide sequences are a common yet poorly understood feature of …

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Targeted Deletion of MIC5 Enhances Trimming Proteolysis of Toxoplasma Invasion Proteins

Susannah D. Brydges, Xing Wang Zhou, My‐Hang Huynh, Jill M. Harper et autres

Limited proteolysis of proteins transiently expressed on the surface of the opportunistic pathogen Toxoplasma gondii accompanies cell invasion and facilitates parasite migration across cell barriers during infection. However, little is known about what factors influence this specialized proteolysis or how these proteolytic …

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A Cleavable Propeptide InfluencesToxoplasmaInfection by Facilitating the Trafficking and Secretion of the TgMIC2–M2AP Invasion Complex

Jill M. Harper, My‐Hang Huynh, Isabelle Coppens, Fabiola Parussini et autres

Propeptides regulate protein function and trafficking in many eukaryotic systems and have emerged as important features of regulated secretory proteins in parasites of the phylum Apicomplexa. Regulated protein secretion from micronemes and host cell invasion are inextricably linked and essential processes for …

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