Carolyn R. Morris

Mitochondrial antioxidant therapy fails to improve obese asthma outcomes

Anne E. Dixon, Olivia J. Garrow, PETER W. CALLAS, Carolyn R. Morris et autres

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Regional Alveolar Damage Despite Lung Protective Ventilation Settings During Robotic-Assisted Laparoscopic Surgery

William G. Tharp, Max W. Breidenstein, Carlos A. Gartner, Yulica Santos-Ortega et autres

BACKGROUND: Robotic-assisted laparoscopic surgery (RALS) in a steep Trendelenburg position creates conditions conducive to cyclical alveolar collapse when using standard lung protective ventilation settings (LPV). The magnitude of force induced by alveolar collapse and expansion is predicted to cause a localized injury, …

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The NADPH oxidase DUOX1 contributes to profibrotic macrophage activation and pulmonary fibrosis

Aida Habibovic, Miao-Chong Joy Lin, Carolyn R. Morris, Caspar Schiffers et autres

Fibrotic lung diseases such as idiopathic pulmonary fibrosis (IPF) are caused by various forms of environmental injury and involve reciprocal interactions between activated (myo)fibroblasts and recruited monocyte-derived macrophages (MoMacs), collectively leading to progressive tissue remodeling. Extending previous findings implicating redox-based mechanisms in …

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A cannabinoid receptor 1 inverse agonist induces weight loss and reduces airway hyperresponsiveness in a mouse model of obese asthma

Carolyn R. Morris, R Chandrasekaran, Isabella M. Butzirus, Nirav Daphtary et autres

Inhibition of the cannabinoid receptor 1, through a pharmacological inverse agonist, not only induces weight loss in a mouse model of obese asthma but also reduces airway hyperresponsiveness, particularly through decreasing elastance/increasing compliance.

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Magnitude of obesity alone does not alter the alveolar lipidome

William G. Tharp, Carolyn R. Morris, Yulica Santos-Ortega, Calvin Vary et autres

Altered lung lipid metabolism has been identified as a potential mechanism of lung dysfunction in obesity, but data in humans are lacking. We measured the alveolar lipidome in bronchoalveolar lavages from subjects with healthy lungs with a wide range of body mass …

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Cannabinoid Receptor 1 Inverse Agonist, INV-202, Increases Surfactant Phosphatidylcholines and Improves Lung Compliance in a Mouse Model of Asthma

Carolyn R. Morris, R Chandrasekaran, Isabella M. Butzirus, Nirav Daphtary et autres

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Obesity exacerbates influenza-induced respiratory disease via the arachidonic acid-p38 MAPK pathway

R Chandrasekaran, Carolyn R. Morris, Isabella M. Butzirus, Zoe F. Mark et autres

Obesity is a risk factor for severe influenza, and asthma exacerbations caused by respiratory viral infections. We investigated mechanisms that increase the severity of airway disease related to influenza in obesity using cells derived from obese and lean individuals, and in vitro …

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Cannabinoid Receptor 1 Inverse Agonist, INV-202, Induces Weight Loss and Reduces Airway Hyperreactivity in a Mouse Model of Obese Asthma

Carolyn R. Morris, R Chandrasekaran, I. Butzirius, Nirav Daphtary et autres

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Diet-induced obesity worsens allergen-induced type 2/type 17 inflammation in airways by enhancing DUOX1 activation

Aida Habibovic, Milena Hristova, Carolyn R. Morris, Miao-Chong Joy Lin et autres

More than 50% of people with asthma in the United States are obese, and obesity often worsens symptoms of allergic asthma and impairs response to treatment. Based on previously established roles of the epithelial NADPH oxidase DUOX1 in allergic airway inflammation, we …

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Supplementary tables 1 and 2 for Mitoquinone mesylate attenuates pathologic features of obese allergic asthma in mice

R Chandrasekaran, Sierra R. Bruno, Zoe F. Mark, Joseph Walzer et autres

Supplementary tables 1 and 2 containing statistical analysis for the manuscript titled " Mitoquinone mesylate attenuates pathologic features of obese allergic asthma in mice".

Mitoquinone mesylate attenuates pathological features of lean and obese allergic asthma in mice

R Chandrasekaran, Sierra R. Bruno, Zoe F. Mark, Joseph Walzer et autres

Obesity is associated with severe, difficult-to-control asthma, and increased airway oxidative stress. Mitochondrial reactive oxygen species (mROS) are an important source of oxidative stress in asthma, leading us to hypothesize that targeting mROS in obese allergic asthma might be an effective treatment. …

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Macrophage-intrinsic DUOX1 contributes to type 2 inflammation and mucus metaplasia during allergic airway disease

Carolyn R. Morris, Aida Habibovic, Christopher M. Dustin, Caspar Schiffers et autres

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