Jianhui Gu

Targeting v-ATPase to Inhibit Lysosomal Acidification: A Study on the Anticancer Mechanism of Phenolic Small Molecules

Lingchen Liao, Jianhui Gu, Jinlin Zheng, Yuzhou Pang et autres

Introduction: Vacuolar-type Adenosine Triphosphatases (v-ATPases) are essential for maintaining lysosomal acidification, a process critical for cancer cell survival and proliferation, making them a promising therapeutic target. This study aims to identify novel phenolic compounds that inhibit v-ATPase, disrupt lysosomal pH homeostasis, and …

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Targeting TMEM175 in Lysosomal Physiology and Human Diseases

Guanfeng Lu, Shujuan Fan, Jianhui Gu, Gang Fang et autres

The transmembrane protein TMEM175, a cation channel located on the lysosomal membrane, plays a crucial role in regulating lysosomal membrane potential and maintaining intralysosomal pH stability. It is involved in various physiological and pathological processes. This review summarizes recent advancements in understanding …

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[Effect of scalp acupuncture stimulation on mood and sleep in children with autism spectrum disorder].

Yong-Nan Jia, Jianhui Gu, Qinglin Wei, Jing Yu-zhen et autres

OBJECTIVE: To observe the effects of penetrating technique of scalp acupuncture on emotion, sleep and function development in children of autism spectrum disorder (ASD). METHODS: =30). In the two groups, the treatment for 3 months was as 1 course, and 2 courses …

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Neurological function following intra-neural injection of fluorescent neuronal tracers in rats

Jianhui Gu, Wen Hu, Dan Liu, Yanping Zhang et autres

Design of the Trigger Interface and Distribution Board for CEBAF 12 GeV Upgrade

Jianhui Gu, Hai Dong, Rubén Cuevas, V. Gyurjyan et autres

The design of the Trigger Interface and Distribution (TID) board for the 12 GeV Upgrade at the Continuous Electron Beam Accelerator Facility (CEBAF) at TJNAL is described. The TID board distributes a low jitter system clock, synchronized trigger, and synchronized multi-purpose SYNC …

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Improved throughput of deep high-aspect-ratio trenches using split-beam laser ablation

David Braun, Jianhui Gu, Richard J. Oram

A 20W 355nm DPSS Q-switched nanosecond pulse width laser, with external beam-splitting optics, was used to simultaneously ablate two 600μm deep, 140μm wide, 13.4mm long blind trenches in silicon using a five line wide cut strategy, achieving a 1.22x throughput improvement compared …

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1064 nm infrared laser ablation of silicon wafer with a water film flowing through the ablated spot

Jianhui Gu

With a water film flowing through the ablated spot, 1064 nm infrared laser ablation of silicon wafer demonstrated material volume removal rate of 0.2 mm3/sec and a small heat-affected-zone for wafer slotting .

Development of CW and passively Q-switched DPSS laser.

Jianhui Gu

In this project, research has been done on DPSS lasers by designing and finally fabricating a high-power DPSS laser based on theoretical analysis and detailed design calculations, and to acquire a thorough understanding of passive Q-switching of DPSS lasers using a GaAs …

Cooling analysis for diode-pumped YAG slabs

Wenjie Xie, Siu-Chung Tam, Hongru Yang, Jianhui Gu et autres

It has been determined that the coolant temperature and the convective heat transfer coefficient (h) are important parameters in the thermal analysis. The coefficient h is affected by the coolant flow rate, the physical properties of the laser slab and the coolant, …

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Characteristics of heat transfer for diode-pumped solid state lasers

Wenjie Xie, Siu-Chung Tam, Yee-Loy Lam, Hongru Yang et autres

The relationship between heat effect and the convective heat transfer coefficient using analytical heat transfer equations is studied. We point out that different convective heat transfer coefficients should be adopted according to different heat densities inside the laser crystal in order to …

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Thermal effect study in excimer laser ablation of polyimide

Jianhui Gu, Eugene Tay, Puay K. Lim, Pean Lim

In this paper we reported the results of investigation on surface deformation caused by thermal effect during excimer laser ablation of polyimide. Obvious surface deformation around the hole entrance was observed during the experiment. The surface topology and cross-section of the ablated …

Nd:YAG laser cleaning of ablation debris from excimer-laser-ablated polyimide

Jianhui Gu, Jason Low, Puay K. Lim, Pean Lim

In the processing of excimer laser ablation of nozzles on polyimide in air, both gases like CO2, CO and HCN and solid debris including C2 approximately C12 are produced in laser ablation area. In this paper, we reported for the first time …