A M Singleton

Residue, distribution and depletion of fluralaner in egg following a single intravenous and transdermal administration in healthy shaver hens: fluralaner residue in egg

Hiroko Enomoto, Baxter A. Elliot, Olivia A. Petritz, Rocio Crespo et autres

The demand for the use of fluralaner in an extra label manner is increasing due to lack of efficacious treatment to combat mites and bed bugs in the poultry industry in the United States. Fluralaner residue data in eggs is lacking and …

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Pharmacokinetics of intravenously and trans-dermally administered fluralaner in healthy laying shaver hens: fluralaner in chickens

Baxter A. Elliot, Hiroko Enomoto, Olivia A. Petritz, Rocio Crespo et autres

Ectoparasite infestations negatively affect both backyard and commercial chicken flocks in the United States. Fluralaner is an isoxazoline shown to be efficacious in treating mite and bed bug infestations in poultry. Fluralaner is approved to treat fleas and ticks in dogs and …

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Lymphopain, a cytotoxic T and natural killer cell-associated cysteine proteinase

Jason Brown, E Matutes, A M Singleton, Catherine J. Price et autres

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Identification of a functionally conserved surface region of rat cytochromes P450IA

Robert J. Edwards, A M Singleton, Bernard P. Murray, Sandra Murray et autres

A region of rat cytochrome P450IA1 at residues 294-301 (Gln-Asp-Arg-Arg-Leu-Asp-Glu-Asn), equivalent to a proinhibitory region of cytochrome P450IA2, was identified by sequence alignment. Anti-peptide antibodies were successfully raised when the peptide was coupled through either its N- or its C-terminus to carrier …

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An anti-peptide antibody targeted to a specific region of rat cytochrome P-450IA2 inhibits enzyme activity

Robert Jeffrey Edwards, A M Singleton, Bernard P. Murray, Dorothea Sesardic et autres

An anti-peptide antibody has been produced which binds to and specifically inhibits the activity of cytochrome P-450IA2 in rat hepatic microsomes. This was achieved by raising an antibody against a synthetic peptide (Ser-Glu-Asn-Tyr-Lys-Asp-Asn), the sequence of which occurs in cytochrome P-450IA2 at …

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Peptide inhibitors of C3 breakdown

Philip W. Peake, Michael Szelke, Dylan M. Jones, A M Singleton et autres

We have investigated the development of substrate-based inhibitors of complement enzymes. Sequences around the scissile Arg77-Ser78 bond of C3 have been synthesized and tested as inhibitors of C3 convertase. The best inhibition was found with the tetrapeptide Ac-Arg-Ser-Asn-Leu-OH (H-576); extending this sequence …

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Species variation in the response of the cytochrome P-450-dependent monooxygenase system to inducers and inhibitors

Alan R. Boobis, Dorothea Sesardic, Bernard P. Murray, Robert Jeffrey Edwards et autres

1. In the safety evaluation of drugs and other chemicals it is important to evaluate their possible inducing and inhibitory effects on the enzymes of drug metabolism. 2. While many similarities exist between species in their response to inducers and inhibitors, there …

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Differences in Lsh gene control over systemic Leishmania major and Leishmania donovani or Leishmania mexicana mexicana infections are caused by differential targeting to infiltrating and resident liver macrophage populations

ERYL V. DAVIES, A M Singleton, Jenefer Mary Blackwell

Earlier studies had shown that the viscerotropic NIH 173 strain of cutaneous Leishmania major fails to come under Lsh gene control. Visceral Leishmania donovani LV9 and another viscerotropic cutaneous strain, Leishmania mexicana mexicana LV4, are controlled by Lsh. The results of double-infection …

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Prophylactic immunization against experimental leishmaniasis. V. Mechanism of the anti-protective blocking effect induced by subcutaneous immunization against Leishmania major infection.

F Y Liew, A M Singleton, Enrìco Cillari, J G Howard

The responsiveness of BALB/c mice to protective i.v. immunization with 150,000-rad irradiated or heat-killed Leishmania major promastigotes can be totally suppressed by prior subcutaneous (s.c.) injection of the same "vaccine." Induction of this effect is leishmania specific for although prevention of protection …

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