Hiroko Enomoto

Carbon hemoperfusion markedly reduces serum meloxicam concentrations in dogs with meloxicam toxicosis

Pei-Tsz Shin, Lijie Zhao, Zsofia Vigh, Tyler E. Johnson et autres

Objective: To investigate the efficacy of synthetically derived activated carbon hemoperfusion (cHP) by measuring serum meloxicam concentration in dogs with meloxicam toxicosis. Methods: 5 dogs with meloxicam overdose that underwent cHP at 3 teaching hospitals between January 2023 and March 2026 were …

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Pharmacokinetics of a Single Subcutaneous Extended‐Release Buprenorphine (Ethiqa XR ) in Healthy Beagles

Kornelia Tiffinger, Hiroko Enomoto, Ronald E. Baynes, Laura Neumann et autres

This study evaluated the pharmacokinetics of an extended-release buprenorphine formulation (Ethiqa XR) in dogs and explored potential sex differences. Twelve healthy intact beagles (6 males and 6 females) received a single subcutaneous injection of Ethiqa XR (0.2 mg/kg). Blood samples were collected …

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Withdrawal interval estimations of oxytetracycline and chlortetracycline in swine using physiologically based pharmacokinetic models: a global trade perspective

Kun Mi, Hiroko Enomoto, Ronald E. Baynes, Zhoumeng Lin

Violative drug residues in animal-derived food are a global food safety concern. Physiologically based pharmacokinetic (PBPK) modeling is a valuable tool for predicting drug residues in edible tissues and determining withdrawal intervals (WDIs). This study aimed to develop a PBPK model for …

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Pharmacokinetics of a Transdermal Buprenorphine Topical Solution in the Cynomolgus Macaque (Macaca fascicularis)

Jeffrey D Fortman, Kristen M. Messenger, Hiroko Enomoto, Lisa C. Halliday

Pain management is an expansive and ever-evolving component of managing nonhuman primates in the research setting. Opioids are a commonly used analgesic medication and are available in a variety of formulations. A novel, long-acting transdermal buprenorphine topical solution was recently approved for …

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Distribution of fluralaner in plasma and liver in broiler breeder hens and roosters following the administration of fluralaner (Bravecto®) via medicated drinking water

Hiroko Enomoto, Rocio Crespo, Laura Neumann, Katie Shamoun et autres

Bed bugs have become resistant to traditional insecticides, and the demand for effective drugs to eradicate bed bugs on poultry farms (especially table-egg layer) and breeder farms (especially broiler breeders) is growing. Fluralaner has been shown to be effective in treating bed …

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Toltrazuril sulfone (Ponazuril) residue depletion in pig tissues and estimated withdrawal intervals

Laura Neumann, Farha Ferdous Sheela, Hiroko Enomoto, Ronald E. Baynes

Ponazuril (Marquis®) is a triazine based antiprotozoal medication labeled to treat equine protozoal myeloencephalitis in the United States. Ponazuril is often used in an extra-label manner to treat coccidiosis in piglets, but tissue residue data is limited. In this study, piglets were …

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Updates on veterinary inquiry metrics to FARAD, withdrawal (WDI) determination, and estimating WDIs for foreign export

Ronald E. Baynes, Hiroko Enomoto, Zhoumeng Lin, Kun Mi

Pharmacokinetics of pradofloxacin, florfenicol, and tulathromycin and response to treatment of steers experimentally infected with Mannheimia hemolytica

Derek M. Foster, Jennifer L. Halleran, Megan E. Jacob, Stephanie C. Hempstead et autres

BACKGROUND: Bovine respiratory disease (BRD) is an economically important disease in the beef industry, and a major driver of therapeutic antibiotic use. Pharmacokinetic data of these drugs is relatively limited in diseased animals. HYPOTHESIS/OBJECTIVE: To determine the concentrations of pradofloxacin, florfenicol, and …

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Residue, distribution and depletion of fluralaner in egg following a single intravenous and transdermal administration in healthy shaver hens: fluralaner residue in egg

Hiroko Enomoto, Baxter A. Elliot, Olivia A. Petritz, Rocio Crespo et autres

The demand for the use of fluralaner in an extra label manner is increasing due to lack of efficacious treatment to combat mites and bed bugs in the poultry industry in the United States. Fluralaner residue data in eggs is lacking and …

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Pharmacokinetics of intranasal and intramuscular flunixin in healthy grower pigs

Emily E. Wiloch, Hiroko Enomoto, Lilly Smith, Ronald E. Baynes et autres

Abstract Flunixin meglumine is a nonsteroidal anti‐inflammatory drug approved to manage pyrexia associated with swine respiratory disease. In the United States, no analgesic drugs are approved for use in swine by the FDA, although they are needed to manage painful conditions. This …

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Pharmacokinetics of intravenously and trans-dermally administered fluralaner in healthy laying shaver hens: fluralaner in chickens

Baxter A. Elliot, Hiroko Enomoto, Olivia A. Petritz, Rocio Crespo et autres

Ectoparasite infestations negatively affect both backyard and commercial chicken flocks in the United States. Fluralaner is an isoxazoline shown to be efficacious in treating mite and bed bug infestations in poultry. Fluralaner is approved to treat fleas and ticks in dogs and …

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Pharmacokinetics of fluralaner as a systemic drug to control infestations of the common bed bug, Cimex lectularius, in poultry facilities

María A. González-Morales, Andrea Thomson, James L. Yeatts, Hiroko Enomoto et autres

Abstract Background Bed bug infestations are re-emerging in the poultry industry throughout the USA. Although the impacts of bed bugs on birds’ health and welfare are poorly understood, adverse outcomes are expected, including stress, anemia, infections and lower production rates. Worker welfare …

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