Zahwa Mariyam

Pristimerin Suppresses Janus Kinase/Signal Transducers and Activators of Transcription Oncogenic Signaling To Drive Mitochondrial and Caspase-Dependent Apoptosis in Multiple Myeloma

Zahwa Mariyam, Kirti S. Prabhu, Ummu Habeeba, Fareed Ahmad et autres

Multiple myeloma (MM) is a plasma cell malignancy characterized by uncontrolled clonal expansion within the bone marrow, and despite major therapeutic advances, it remains largely incurable. The identification of novel agents capable of overcoming apoptosis resistance and targeting critical survival pathways is …

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Sanguinarine Induces ROS ‐Mediated Mitochondrial Dysfunction and Inhibits AKT / GSK3 Signaling to Potentiate Apoptotic Effects in Cutaneous T‐Cell Lymphoma

Shilpa Kuttikrishnan, Muhammad Suleman, Fareed Ahmad, Zahwa Mariyam et autres

Cutaneous T-cell lymphoma (CTCL) is a rare non-Hodgkin lymphoma with limited durable treatment options and poor overall survival, underscoring the need for new therapeutic approaches. Sanguinarine (SNG), a natural benzophenanthridine alkaloid, has demonstrated anticancer activity in several malignancies, but its potential role …

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Pristimerin drives ROS-dependent apoptosis in cutaneous T-cell lymphoma via inhibition of the AKT–SKP2 axis

Shilpa Kuttikrishnan, Rasheeda Anver, Fareed Ahmad, Zahwa Mariyam et autres

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Selective induction of apoptosis in T-cell acute lymphoblastic leukemia by pristimerin through dual PI3K/AKT pathway inhibition and ROS generation

Shilpa Kuttikrishnan, Zahwa Mariyam, Fareed Ahmad, Mohammad Suleman et autres

T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive hematological malignancy characterized by the aberrant activation of survival pathways, particularly the PI3K/AKT axis. Pristimerin (Prist), a naturally occurring quinonemethide triterpenoid, has recently gained attention for its anti-cancer potential. In this study, we demonstrate …

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Targeting mTOR and Its Associated Signaling to Induce Cell Death in Breast Cancer Stem Cells

Kirti S. Prabhu, Zahwa Mariyam, Syed Abdul Rahman, Shilpa Kuttikrishnan et autres

Breast cancer (BC) is a frequently diagnosed neoplasm in women and the second major cause of cancer-related deaths. Many BC patients develop metastasis and advanced tumors, increasing morbidity and mortality. There is substantial evidence that tumor relapses in BC patients are driven …

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PI3 K/AKT/mTOR pathway and its role in breast cancer stem cells

Kirti S. Prabhu, Shilpa Kuttikrishnan, Zahwa Mariyam, Ummu Habeeba et autres

Cancer stem cells (CSCs) are a small subpopulation bearing self-renewal ability, mediating tumor initiation and propagation. Several molecular pathways, including the PI3K/AKT/mTOR pathway, are known to be aberrantly activated in cancers. In CSCs, PI3K/AKT/mTOR pathway has been associated with attribution of various …

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Curcumin induces apoptosis via downregulation of SKP2 and induction of GADD45A/CDKN1A expression through generation of ROS in cutaneous T-cell lymphoma cells

Shilpa Kuttikrishnan, Muhammad Suleman, Fareed Ahmad, Zahwa Mariyam et autres

Curcumin, a plant derived natural product isolated from Curcuma longa. The aim of this study is to investigate the anti-proliferative effects and the underlying mechanisms of curcumin in Cutaneous T cell lymphoma (CTCL), a type of non-Hodgkin lymphoma that primarily affects the …

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Nectin-4: A promising prognostic marker and therapeutic target in cancer

Shilpa Kuttikrishnan, Kirti S. Prabhu, Ummu Habeeba, Zahwa Mariyam et autres

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H2AX: A key player in DNA damage response and a promising target for cancer therapy

Kirti S. Prabhu, Shilpa Kuttikrishnan, Nuha Ahmad, Ummu Habeeba et autres

Cancer is caused by a complex interaction of factors that interrupt the normal growth and division of cells. At the center of this process is the intricate relationship between DNA damage and the cellular mechanisms responsible for maintaining genomic stability. When DNA …

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Anticancer Potential and Molecular Targets of Pristimerin in Human Malignancies

Kirti S. Prabhu, Serah Jessy, Shilpa Kuttikrishnan, Farina Mujeeb et autres

The growing global burden of malignant tumors with increasing incidence and mortality rates underscores the urgent need for more effective and less toxic therapeutic options. Herbal compounds are being increasingly studied for their potential to meet these needs due to their reduced …

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