Fareed Ahmad

Protein Arginine Methyltransferase-5 Inhibition Induces Growth Arrest and Death in Triple-Negative Breast Cancer Cells

Majdi Al-Alawneh, Fareed Ahmad, Abdallah Musa Abdallah, Samir Jaoua et autres

Background: PRMT5, or protein arginine methyltransferase 5, is recognized as an epigenetic regulator that suppresses gene transcription through symmetric dimethylation of histone arginine residues, including histone H4 arginine 3 (H4R3me2s) and histone H3 arginine 8 (H3R8me2s), modifications associated with chromatin condensation and …

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Fetal bovine serum-mediated biomimetic engineering of gold nanoparticles induces apoptosis in colorectal cancer cells

Anu Jayanthi Panicker, Vaisali Chandrasekar, Kirti S. Prabhu, Jolly Bhadra et autres

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Pristimerin Suppresses Janus Kinase/Signal Transducers and Activators of Transcription Oncogenic Signaling To Drive Mitochondrial and Caspase-Dependent Apoptosis in Multiple Myeloma

Zahwa Mariyam, Kirti S. Prabhu, Ummu Habeeba, Fareed Ahmad et autres

Multiple myeloma (MM) is a plasma cell malignancy characterized by uncontrolled clonal expansion within the bone marrow, and despite major therapeutic advances, it remains largely incurable. The identification of novel agents capable of overcoming apoptosis resistance and targeting critical survival pathways is …

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Sanguinarine Induces ROS ‐Mediated Mitochondrial Dysfunction and Inhibits AKT / GSK3 Signaling to Potentiate Apoptotic Effects in Cutaneous T‐Cell Lymphoma

Shilpa Kuttikrishnan, Muhammad Suleman, Fareed Ahmad, Zahwa Mariyam et autres

Cutaneous T-cell lymphoma (CTCL) is a rare non-Hodgkin lymphoma with limited durable treatment options and poor overall survival, underscoring the need for new therapeutic approaches. Sanguinarine (SNG), a natural benzophenanthridine alkaloid, has demonstrated anticancer activity in several malignancies, but its potential role …

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Pristimerin drives ROS-dependent apoptosis in cutaneous T-cell lymphoma via inhibition of the AKT–SKP2 axis

Shilpa Kuttikrishnan, Rasheeda Anver, Fareed Ahmad, Zahwa Mariyam et autres

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Involvement of B Cell Subsets in Patients With Steven Johnson Syndrome/Toxic Epidermal Necrolysis ( SJS / TEN )

Fareed Ahmad, Jericha Miles P. Mateo, Febu Elizabeth Joy, Gazala Anamangadan et autres

Steven-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are rare, acute inflammatory skin reactions with a high mortality rate of ~20%–50% [1]. It is mainly related to medications, which can trigger an acute reaction causing extensive skin necrosis and detachment [2, 3]. …

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Longitudinal Plasma Proteome of Pfizer/BNT162b2 Pre- and Postbooster Vaccinated Healthy Individuals Reveals Distinct Protein Profiles upon SARS-CoV-2 Spike Protein Stimulation

Thesni Raheed, Lubna Therachiyil, Varghese Inchakalody, Paleerath Peerapen et autres

A COVID-19 booster dose has been found to be effective in our fight against SARS-CoV-2 infection. However, their long-term beneficial or adverse effects among healthy individuals are not fully understood. We investigated the impact of the Pfizer-BioNTech-(BNT162b2) booster dose on plasma proteome …

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Journal scan

Fareed Ahmad, S Clough, Nigel D Robb, G Gerrard et autres

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Targeting FOXM1 regulates metabolic signatures through ROS-dependent JNK/Bmi1/Skp2 axis in human cutaneous T-cell lymphoma

A. S. S. I. Khan, Maha Victor Agha, Fareed Ahmad, Rasheeda Anver et autres

Cutaneous T-cell lymphoma (CTCL) is a progressive and heterogeneous malignancy characterized by deregulated metabolic reprogramming and cancer stemness, with limited therapeutic options. Therefore, elucidating the mechanisms driving metabolic reprogramming and poor clinical outcomes in CTCL is imperative. Forkhead box protein M1 (FOXM1), …

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The Neurogenic Inflammation Mediator Endothelin‐1 Causes Human Skin Barrier Disruption in Atopic Dermatitis via an ETAR / TRPA1 ‐Axis

Rari Leo, Anh Jochebeth, Nabeel Abdulrahman, Maha Victor Agha et autres

BACKGROUND: Atopic dermatitis (AD) is a common, relapsing inflammatory skin disease driven by an immune imbalance, microbial dysbiosis, and skin barrier impairment, culminating in (neurogenic) inflammation and itch. We hypothesized that the neuropeptide and pruritogen endothelin-1 (ET-1) contributes to AD pathology by …

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Selective induction of apoptosis in T-cell acute lymphoblastic leukemia by pristimerin through dual PI3K/AKT pathway inhibition and ROS generation

Shilpa Kuttikrishnan, Zahwa Mariyam, Fareed Ahmad, Mohammad Suleman et autres

T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive hematological malignancy characterized by the aberrant activation of survival pathways, particularly the PI3K/AKT axis. Pristimerin (Prist), a naturally occurring quinonemethide triterpenoid, has recently gained attention for its anti-cancer potential. In this study, we demonstrate …

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Ketamine and dodecyl maltoside synergy as a potential topical therapeutic approach for melanoma

Sourour Idoudi, Hadeel Kheraldine, Gazala Anamangadan, Fareed Ahmad et autres

Melanoma is the most aggressive subtype of skin cancer with limited treatment options due to toxicity and therapy resistance. This study investigates the anticancer potential of ketamine (KET), an anesthetic recently reported to have anticancer effects, in combination with dodecyl maltoside (DDM), …

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