M.C. Maguire

Signal Intensity versus Spatial Resolution: Divergent MPI Performance of SPIONs in Mesenchymal Stromal Cell Labelling

Serbay Özkan, Elena Ureña-Horno, Reilteann Niamh Saul, M.C. Maguire et autres

Background and Aim: Magnetic Particle Imaging (MPI) is a highly sensitive modality for non-invasive cell tracking; however, imaging performance is strongly influenced by nanoparticle properties and intracellular behavior following labelling. In this study, four commercially available superparamagnetic iron oxide nanoparticles (SPIONs) - …

gb, tr (code pays fourni par la source)

1H MR spectroscopy to evaluate the effects of lonidamine and temozolomide treatment in a mouse model of glioblastoma

Tareq Alrashidi, Sourav Bhaduri, Elisabeth Non Gash, Mohesh Moothanchery et autres

Motivation: To develop an alternate effective therapy for treating glioblastomas. Goal(s): To assess metabolic changes as therapeutic indices of treatment response to Lonidamine (LND)and temozolomide (TMZ) against glioblastoma (GBM). Approach: C57BL6 mice implanted with GL261 GBM cells were treated with saline or …

Evaluating Labelling Efficiency of Commercial SPIONs in Mesenchymal Stem/Stromal Cells for Magnetic Particle Imaging Applications

Serbay Özkan, Elena Ureña-Horno, Richard G. Saul, M.C. Maguire et autres

Abstract Magnetic Particle Imaging (MPI) is a state-of-the-art, highly sensitive modality for non-invasive cell tracking. This study evaluated labelling efficiency, biocompatibility, intracellular localization, and MPI detection sensitivity of four commercial superparamagnetic iron oxide nanoparticles (SPIONs)—ProMag, VivoTrax, SynoMag-D, and Ferumoxytol—in mouse mesenchymal stem/stromal …

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Assessing host-tumour vasculature and glycolytic metabolism in response to hypoxia in a chick CAM model of GBM using MRI and MRS

Elisabeth Non Gash, Sarah Barnett, M.C. Maguire, Stephen Pickup et autres

Motivation: Understanding vasculature, hypoxia and glycolysis in GBM is paramount towards understanding its resistance to therapies, but cannot be done in vitro. The CAM model is attractive as it provides the interaction between host vasculature and the tumour. Goal(s): Optimise MRI and …

1H MR spectroscopy and IVIM-DWI to evaluate the effect of a choline kinase inhibitor and temozolomide therapy in a mouse model of glioblastoma

Tareq Alrashidi, Sourav Bhaduri, Elisabeth Non Gash, Mohesh Moothanchery et autres

Motivation: There is a lack of comprehensive understanding regarding the impact of choline kinase inhibition and standard chemotherapy on preclinical GBM models. Goal(s): The primary goal of this study was to elucidate the treatment response mechanism in a preclinical GBM mouse model. …

Forging out-of-equilibrium supramolecular gels

Simona Bianco, Fin Hallam Stewart, Santanu Panja, Asra Zyar et autres

The design of supramolecular hydrogels comprising aligned domains is important for the fabrication of biomimetic materials and applications in optoelectronics. One way to access such materials is by the self-assembly of small molecules into long fibres, which can be aligned using an …

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In Situ Neutron Diffraction Study of the Influence of Microstructure on the Mechanical Response of Additively Manufactured 304L Stainless Steel

Donald W. Brown, David P. Adams, Levente Balogh, John S. Carpenter et autres

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Compressive and Tensile Stress–Strain Responses of Additively Manufactured (AM) 304L Stainless Steel at High Strain Rates

Bo Song, E. Nishida, Brett Sanborn, M.C. Maguire et autres

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Comparative shock response of additively manufactured versus conventionally wrought 304L stainless steel

Jonathan Wise, David P. Adams, E. Nishida, Bo Song et autres

Gas-gun experiments have probed the compression and release behavior of impact-loaded 304L stainless steel specimens that were machined from additively manufactured (AM) blocks as well as baseline ingot-derived bar stock. The AM technology permits direct fabrication of net- or near-net-shape metal parts. …

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Predicting Mesoscale Microstructural Evolution in Electron Beam Welding

Theron Rodgers, Jonathan D Madison, Veena Tikare, M.C. Maguire

Using the kinetic Monte Carlo simulator, Stochastic Parallel PARticle Kinetic Simulator, from Sandia National Laboratories, a user routine has been developed to simulate mesoscale predictions of a grain structure near a moving heat source. Here, we demonstrate the use of this user …

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Comparing Field Emission Electron Microprobe to Traditional EPMA for Analysis of Metallurgical Specimens

D. F. Susan, Richard P. Grant, J.M. Rodelas, J.R. Michael et autres

DF Susan, RP Grant, JM Rodelas, JR Michael, MC Maguire; Comparing Field Emission Electron Microprobe to Traditional EPMA for Analysis of Metallurgical Spec

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Comparative Shock Response of Additively Manufactured Versus Conventionally Wrought 304L Stainless Steel

J.L. Wise, David P. Adams, E. Nishida, Bin Song et autres

Abstract not provided.