Serbay Özkan

Blood Biomarker Tenascin-C for Detection of Radiation Cardiotoxicity: An Animal Model

Ecem Demir, Karolin Yanar, Pınar Atukeren, Serbay Özkan et autres

Purpose: The aim of this study was to test the hypothesis that Tenascin-C (TNC) levels increase following thoracic radiotherapy (RT), and that elevated serum TNC levels are associated with corresponding increases in myocardial TNC expression in histopathological specimens, supporting its role as …

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Signal Intensity versus Spatial Resolution: Divergent MPI Performance of SPIONs in Mesenchymal Stromal Cell Labelling

Serbay Özkan, Elena Ureña-Horno, Reilteann Niamh Saul, M.C. Maguire et autres

Background and Aim: Magnetic Particle Imaging (MPI) is a highly sensitive modality for non-invasive cell tracking; however, imaging performance is strongly influenced by nanoparticle properties and intracellular behavior following labelling. In this study, four commercially available superparamagnetic iron oxide nanoparticles (SPIONs) - …

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Melatonin as a Radioprotective Agent: Assessing Its Efficacy in Preventing Lung Injury Induced by Radiation Therapy

Ecem Demir, Karolin YANARPınar ATUKEREN, Pınar Atukeren, Serbay Özkan et autres

Aim: The purpose of our study was to investigate whether melatonin (MLT) can protect against radiation-induced lung injury (RILI) in a rat model, with particular emphasis on dose-dependent effects in preventing pneumonitis and pulmonary fibrosis following radiotherapy (RT). Materials and Methods:Treatment groups …

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Optimizing Labeling of Adipose-Derived Mesenchymal Stem/Stromal Cells with Promag Superparamagnetic Iron Oxide Nanoparticles for Clinically Translatable Magnetic Particle Imaging

Serbay Özkan, Charlotte Trot, Patricia Murray

Objective: This study evaluated the labeling efficiency of human adipose-derived mesenchymal stem/stromal cells (MSCs) with ProMag superparamagnetic iron oxide nanoparticles (SPIONs) under adherent and suspension conditions, aiming to define practical parameters for translational use. Methods: The MSCs were labeled with 3 ProMag …

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Assessment of Liver Damage in an Experimental Model of Streptozotocin-Induced Diabetes in Sprague Dawley Rats: Focusing on Morphological and Oxidative Stress Status

Serbay Özkan, Meral Koyutürk

Objective: Diabetes mellitus (DM) is a widespread metabolic disorder that causes severe complications, including damage to various organs.The liver, a pivotal organ involved in metabolic regulation, is particularly vulnerable to diabetic injury.This study aimed to investigate the effects of diabetes on the …

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Evaluating Labelling Efficiency of Commercial SPIONs in Mesenchymal Stem/Stromal Cells for Magnetic Particle Imaging Applications

Serbay Özkan, Elena Ureña-Horno, Richard G. Saul, M.C. Maguire et autres

Abstract Magnetic Particle Imaging (MPI) is a state-of-the-art, highly sensitive modality for non-invasive cell tracking. This study evaluated labelling efficiency, biocompatibility, intracellular localization, and MPI detection sensitivity of four commercial superparamagnetic iron oxide nanoparticles (SPIONs)—ProMag, VivoTrax, SynoMag-D, and Ferumoxytol—in mouse mesenchymal stem/stromal …

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Strategies Towards Standardizing Calibration Methods for Magnetic Particle Imaging (MPI) Signal Quantification: Solution vs. Cellular Environments

Elena Ureña-Horno, Mahon L. Maguire, Serbay Özkan, L. O’Brien et autres

Magnetic Particle Imaging (MPI) is a powerful technique for non-invasive imaging and iron quantification using superparamagnetic iron oxide nanoparticles (SPIONs), with applications ranging from in in vivo cell tracking to tracer distribution and biodistribution studies. As the MPI community continues to grow …

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453 The Role of Tenascin C as an Early Detection Marker for Radiation-Induced Cardiotoxicity and the Impact of Melatonin Dosage-in vivo rat study

Ecem Demir, Fazilet Öner Dinçbaş, Karolin Yanar, Pınar Atukeren et autres

Dynamic analysis of metabolic and ultrastructural changes in mesenchymal stem cells at hypoxic preconditioning and post-preconditioning stages: Cobalt chloride on the spotlight

Serbay Özkan, Başak Işıldar, Duygu Neccar, Meral Koyutürk

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Cardiotoxicity prevention in thoracic radiotherapy: The effect of different melatonin doses on the level of oxidation markers -in vivo animal study

Ecem Demir, Karolin Yanar, Pınar Atukeren, Serbay Özkan et autres

Radiation-induced cardiotoxicity (RIC) is a significant adverse effect of thoracic radiotherapy (RT), leading to oxidative stress, inflammation, endothelial dysfunction, myocardial fibrosis, vascular damage, and cardiac dysfunction. Melatonin (MLT), a potent antioxidant and radioprotective agent, has been suggested to mitigate these effects. This …

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Strategies towards standardizing calibration methods for magnetic particle imaging (MPI) signal quantification: solution vs. cellular environments

Elena Ureña-Horno, Mahon L. Maguire, Serbay Özkan, L. O’Brien et autres

cell tracking to tracer distribution and biodistribution studies. As the MPI community continues to grow and diversify, there is an increasing recognition of the need for standardized approaches in signal quantification to ensure reproducibility, comparability, and reliable interpretation of results across studies. …

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Preconditioning of Human Umbilical Cord Mesenchymal Stem Cells with a Histone Deacetylase Inhibitor: Valproic Acid

Başak Işıldar, Serbay Özkan, Meral Koyutürk

Background: Mesenchymal stem cells (MSCs) play a key role in regenerative medicine due to their capacity to differentiate into multiple cell lines, regulate the immune system, and exert paracrine effects. The therapeutic impact of MSCs is primarily mediated through their secretome. The …

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