P.K. Marimuthu

PP153 A randomized, open-label phase ii study comparing a novel regimen of dose-dense docetaxel-cyclophosphamide alternating with epirubicin-cisplatin against anthracycline-taxane in early TNBC, stratified for the use of low-dose nivolumab (NEOPLANETx study)

Josh Thomas Georgy, A. Joel, Deepa Susan Joy Philip, D.B. Thumaty et autres

Recent advances in early triple-negative breast cancer (TNBC) treatment have incorporated immune checkpoint inhibitors and carboplatin, notably in the KEYNOTE-522 trial, enhancing pathological complete response (pCR) and event-free survival. However, consistent benefits in overall survival are unclear, and carboplatin regimens often cause …

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862P Neoadjuvant chemo-immunotherapy using carboplatin, nab-paclitaxel, oral metronomic therapy and low dose nivolumab for “borderline resectable” oral cavity carcinoma: A prospective phase II single-arm trial (NeoLOCUS)

P.K. Marimuthu, Amit Jiwan Tirkey, Sumanta Kumar Sahu, A.O. John et autres

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143P Molecular profiling and treatmentrelated outcomes with chemo-immunotherapy in patients with mucosal melanoma: A 10-year single-centre retrospective study

P. Jambunathan, Akshita Singh, Z. Thomas, Divya Bala Thumaty et autres

Primary mucosal melanomas are rare and aggressive malignancies with limited available information as they are excluded from melanoma trials. They are unique as they exhibit a different molecular profile and mutational burden, when compared to cutaneous melanoma. Activity of commonly used regimens …

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504P Real-world outcomes with induction systemic therapy for stage III in eligible for upfront local therapy: Pre vs post immunotherapy era in a tertiary referral centre

P.K. Marimuthu, Ashish Singh, A. Joel, Divya Bala Thumaty et autres

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370P Low-dose nivolumab with induction chemotherapy for inoperable HNSCC in 111 patients: Response rates, survival, and implications for LMICs

Josh Thomas Georgy, Z. Thomas, Rosh Varghese Georgy, Soumya Susan Regi et autres

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