A. De Cata

Pulmonary arterial hypertension: guidelines and unmet clinical needs

Dilia Giuggioli, Cosimo Bruni, Fabio Cacciapaglia, Fabio Dardi et autres

The term pulmonary arterial hypertension (PAH) identifies a heterogeneous group of diseases characterized by a progressive increase in pulmonary arterial resistance (PVR), which causes a significant burden in terms of quality of life, right heart failure and premature death. The pathogenesis of …

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AB0171 THE IMMUNOMODULATORY AND ANTI-INFLAMMATORY EFFECTS OF BOSENTAN IN SYSTEMIC SCLEROSIS

Maria Giulia Tinti, Tommaso Mazza, Leonardo D’Agruma, A. De Cata

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A review of network meta-analysis comparing biologics in the treatment of rheumatoid arthritis.

Gianfranco Gigliucci, U. Massafra, Bruno Frediani, A. De Cata et autres

OBJECTIVE: Even though in recent years significant improvements have been made in the management of patients with rheumatoid arthritis due to the introduction of biologic agents, it is still difficult to identify the most effective and safest available treatment. The choice and …

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Plasma Leptin in Patients at Intermediate to High Cardiovascular Risk With and Without Type 2 Diabetes Mellitus

Martina Montagnana, Cristiano Fava, Giovanni Targher, Massimo Franchini et autres

BACKGROUND: A number of clinical studies have demonstrated that leptin concentrations are related to the metabolic disturbances that constitute the metabolic syndrome (MetS) and to diabetes mellitus (DM). AIM: To investigate possible determinants of leptin concentrations in a sample of patients at …

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Digital ulcers in scleroderma patients: A retrospective observational study

A. De Cata, Matilde Inglese, Francesca Molinaro, Salvatore De Cosmo et autres

BACKGROUND: The guidelines for digital ulcers (DUs) management in systemic sclerosis (SSc) indicate the use of iloprost to induce wound healing and bosentan to prevent the onset of new DU. The aim of our study was to evaluate whether the combination treatment …

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Ultrasound signs of pulmonary fibrosis in systemic sclerosis as timely indicators for chest computed tomography

Marco Sperandeo, A. De Cata, Francesca Molinaro, Francesca M. Trovato et autres

OBJECTIVES: Systemic sclerosis (SSc) patients in the early stages of pulmonary fibrosis (PF) often have few or no symptoms, normal to borderline pulmonary function tests, and negative chest X-ray (CXR); high-resolution computed tomography (HRCT) is the only reliable means of detecting the …

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The transcriptional regulators, the immune system and the the circadian clock.

Manlio Vinciguerra, Michela Borghesan, Valerio Pazienza, Ada Piepoli et autres

The immune system function oscillates with a 24-hour period driving circadian rhythmicity of immune responses. A circadian timing system comprising central and peripheral oscillators entrains body rhythmicity of physiology and behavior to environmental cues by means of humoral signals and autonomic neural …

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Transcriptional regulators, the circadian clock and the immune system.

Manlio Vinciguerra, Michela Borghesan, Pazienza, Ada Piepoli et autres

Arterial endothelial dysfunction and idiopathic deep venous thrombosis.

Gianluigi Mazzoccoli, Massimo Grilli, Francesca Ferrandino, Massimiliano Copetti et autres

Recent epidemiological studies have highlighted higher risk of subsequent development of atherosclerotic disease in patients with deep venous thrombosis (DVT). We evaluated the Flow Mediated Dilation (FMD) looking for arterial endothelial dysfunction, predictive for future ischaemic cardiovascular events, in patients with idiopathic …

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A timetable of 24-hour patterns for human lymphocyte subpopulations.

Gianluigi Mazzoccoli, Robert B. Sothern, A. De Cata, Francesco Giuliani et autres

Specific lymphocyte cell surface molecules involved in antigen recognition and cell activation present different circadian patterns, with peaks and troughs reflecting a specific time-related compartment of immune cell function. In order to study the dynamics of variation in expression of cytotoxic lymphocyte …

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Hypothalamus-hypophysis-thyroid axis function in healthy aging.

Gianluigi Mazzoccoli, Valerio Pazienza, Ada Piepoli, Lucia Anna Muscarella et autres

There is an increased frequency of dysthyroidism in elderly people. We investigated whether there are differences among healthy young middle-aged and elderly people in the 24 hour secretory profiles of TRH, TSH and free thyroxine. The study was carried out on fifteen …

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Change of γδTCR-Expressing T Cells in Healthy Aging

Gianluigi Mazzoccoli, Gianluigi Vendemiale, A. De Cata, Roberto Tarquini

A mature T-cell lineage with the capacity to proliferate in response to receptor-mediated signals and to display non-major histocompatibility complex (MHC)-restricted cytolysis expresses a CD3-associated heterodimer made up of the protein encoded by the T-cell receptor (TCR) gamma-gene. We investigated the possible …

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