Robert B. Sothern

As-One-Goes Blood Pressure and Heart Rate Monitoring: A Chronobiology Approach with Applications in Clinical Practice and Basic Science

Germaine Cornélissen, Yoshihiko Watanabe, Larry A. Beaty, Chase Turner A et autres

Assessing influences of space weather on human physiology often relies on correlations between the socio-biological variableand the environment.One major pitfall of such an approach is the disregard for periodicities characterizing both biology and nature, many of them shared between the two systems.Alternative, …

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Obituary: Pietro Cugini (13 December 1936 – 6 April 2020)

Germaine Cornélissen, Robert B. Sothern, L Sackett-Lundeen, Keiko Uezono et autres

Chronobiology lost a great and distinguished physician-scientist, Pietro Cugini (Figure 1). He will be dearly missed by his family, his friends, and the field he helped shape and guide as he remained active until the end of his life at 83 years …

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Dihydropyrimidine Dehydrogenase Activity in Human Blood Mononuclear Cells

Mendel Tuchman, Reinhard von Roemeling, William J.M. Hrushesky, Robert B. Sothern et autres

Dihydropyrimidine dehydrogenase (DPD; EC 1.3.1.2) catalyzes the rate-limiting reaction in the catabolism of endogenous uracil and thymine and exogenous fluoropyrimidines. DPD activity was studied in human blood mononuclear cell supernatants utilizing a new and sensitive radiochromatographic assay. Total DPD activity showed a …

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Positive Effect of Fever on Symptoms of Autism

Helen V. Ratajczak, Robert B. Sothern

Autism is no longer considered incurable. Numerous reports have documented cures of autism, especially in young children. In addition, transient improvement in symptoms of ASD has been reported during natural fever in response to infection, suggesting the potential use of fever as …

Measurement in Saliva From Neurotypical Adults of Biomarkers Pertinent to Autism Spectrum Disorders

Helen V. Ratajczak, Robert B. Sothern

AIM: Measure biomarkers pertinent to autism in saliva from humans. MATERIALS & METHODS: At 7:30 PM (reading instructions) and 8:30 PM (hearing instructions), neurotypical adults (6 M, 6 F) each spat into tubes containing protease inhibitors. Cells were counted, samples aliquoted, frozen …

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Estral Rhythms in Natural Killer Cell Activity and Metastatic Behavior1

William J.M. Hrushesky, Scott A. Gruber, Robert B. Sothern, Rosemary A. Hoffman et autres

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54 Circannual Aspects of Urinary Catecholamine Excretion in a Healthy Man

Robert B. Sothern, C. S. Leach, F. Halberg

Seasonality of Influences on Disorders of Psychological Development: A Synopsis

Helen V. Ratajczak, Robert B. Sothern

There are many contributing factors to the development of disorders of psychological development that can interact in a complicated way to cause alterations of gene expression that result in autism, schizophrenia, or other disorders. It is therefore important to consider the environment …

In memoriam, Salvador Sanchez Alfonso de la Pena, MD, PhD: A comrade in the chronousphere (November 14, 1948 - November 2, 2011)

R. B. Singh, Germaine Cornélissen, Robert B. Sothern, Jonathan Levi Rito Medina et autres

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The Chronobra identifies prevailing mammary vascularity as a candidate variable in breast cancer post-operative outcome prediction

H. W. Simpson, David W. George, Robert B. Sothern, K. Griffiths

We previously described a menstrual heat cycle of the breast in four groups of women (healthy, family history of breast cancer, benign breast disease, 'cancer-associated') who wore a thermometric brassiere (Chronobra). We now ask if 'breast minus oral temperature', indicating 'breast-associated vascularity', …

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Menstrual Cycle and Respiratory Symptoms in a General Nordic–Baltic Population

Ferenc Macsali, Cecilie Svanes, Robert B. Sothern, Bryndís Benediktsdóttir et autres

RATIONALE: There is little knowledge of variations in respiratory symptoms during the menstrual cycle in a general population, and potential modifying factors are not investigated. OBJECTIVES: To investigate menstrual cycle variation in respiratory symptoms in a large general population, using chronobiology methodology, …

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A risperidone-induced prolactinoma resolved when a woman with schizoaffective disorder switched to ziprasidone: a case report.

Gail T Arcari, Asante K Mendes, Robert B. Sothern

Antipsychotic drug therapy, e.g., risperidone, can be associated with endocrine abnormalities, including an increase in serum prolactin level (sPrl) due to a drug-induced benign pituitary tumor (prolactinoma). A few case reports have noted a resolution of hyperprolactinemia and prolactinoma after cessation of …