Francesca Ferrandino

Correction: Notch3-regulated microRNAs impair CXCR4-dependent maturation of thymocytes allowing maintenance and progression of T-ALL

Ilaria Sergio, Claudia Varricchio, Sandesh Kumar Patel, Martina Del Gaizo et autres

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Notch3-regulated microRNAs impair CXCR4-dependent maturation of thymocytes allowing maintenance and progression of T-ALL

Ilaria Sergio, Claudia Varricchio, Sandesh Kumar Patel, Martina Del Gaizo et autres

it, us (code pays fourni par la source)

Notch3-regulated microRNAs impair CXCR4-dependent maturation of thymocytes allowing maintenance and progression of T-ALL

María Pía Felli, Ilaria Sergio, Martina Del Gaizo, Sandesh Kumar Patel et autres

Abstract Malignant transformation of T-cell progenitors causes T-cell acute lymphoblastic leukemia (T-ALL), an aggressive childhood lymphoproliferative disorder. Activating mutations of Notch1 and overexpression of Notch3, as well as rare Notch3 activating mutations have been detected in T-ALL patients. In this study, we …

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Inclusion of the Inducible Caspase 9 Suicide Gene in CAR Construct Increases Safety of CAR.CD19 T Cell Therapy in B-Cell Malignancies

Marika Guercio, Simona Manni, Iolanda Boffa, Simona Caruso et autres

T cells engineered with chimeric antigen receptor (CAR-T cells) are an effective treatment in patients with relapsed/refractory B-cell precursor acute lymphoblastic leukemia or B-cell non-Hodgkin lymphoma. Despite the reported exciting clinical results, the CAR-T cell approach needs efforts to improve the safety …

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Notch and NF-κB: Coach and Players of Regulatory T-Cell Response in Cancer

Francesca Ferrandino, Paola Grazioli, Diana Bellavia, Antonio Francesco Campese et autres

The Notch signaling pathway plays multiple roles in driving T cell fate decisions, proliferation and aberrant growth. NF-κB is a cell-context key player interconnected with Notch signalling either in physiological and in pathological conditions. This review focuses on how multilayered cross-talk between …

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Intrathymic Notch3 and CXCR4 combinatorial interplay facilitates T-cell leukemia propagation

Francesca Ferrandino, Giovanni Bernardini, Georgia Tsaouli, Paola Grazioli et autres

Notch hyperactivation dominates T-cell acute lymphoblastic leukemia development, but the mechanisms underlying “pre-leukemic” cell dissemination are still unclear. Here we describe how deregulated Notch3 signaling enhances CXCR4 cell-surface expression and migratory ability of CD4 + CD8 + thymocytes, possibly contributing to “pre-leukemic” …

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PO-393 Notch3 and CXCR4 cross-signalling sustains acute T-cell leukaemia progression

Georgia Tsaouli, Francesca Ferrandino, Giovanni Bernardini, Paola Grazioli et autres

and SMART technology, in conjunction with two novel nextgeneration sequencing (NGS) library preparation kits, using the same primer pairs, to capture full-length variable regions of TCR-a and -b chains.Material and methods Method 1, using the SMARTer Human scTCRa/b Profiling Kit, permits NGS …

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Notch3 sustains CXCR4 expression in acute T cell lymphoblastic leukemia progression

Francesca Ferrandino, G Bernardini, Paola Grazioli, Antonio Francesco Campese et autres

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Multidrug Resistance Protein‐4 Influences Aspirin Toxicity in Human Cell Line

Isabella Massimi, Ambra Ciuffetta, Flavia Temperilli, Francesca Ferrandino et autres

Overexpression of efflux transporters, in human cells, is a mechanism of resistance to drug and also to chemotherapy. We found that multidrug resistance protein-4 (MRP4) overexpression has a role in reducing aspirin action in patients after bypass surgery and, very recently, we …

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CXCR4 deregulated expression in Notch3-induced T cell leukemia

Francesca Ferrandino, Giovanni Bernardini, Antonio Francesco Campese, Paola Grazioli et autres

Arterial endothelial dysfunction and idiopathic deep venous thrombosis.

Gianluigi Mazzoccoli, Massimo Grilli, Francesca Ferrandino, Massimiliano Copetti et autres

Recent epidemiological studies have highlighted higher risk of subsequent development of atherosclerotic disease in patients with deep venous thrombosis (DVT). We evaluated the Flow Mediated Dilation (FMD) looking for arterial endothelial dysfunction, predictive for future ischaemic cardiovascular events, in patients with idiopathic …

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Echopatterns of the ovarian dermoid tumor.

Aniello Di Meglio, G. Di Meglio, A. Esposito, D. Paladini et autres

The authors report the ovarian dermoid echopatterns observed in 189 cases. The ultrasonic key of the diagnosis is a particular "pearly-gray" colour. The early diagnosis by USG gives the Gynecologist some advantages in: a) avoiding the operation in those cases of small …

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