Yuhei Morioka

Author Correction: Attenuated fusogenicity and pathogenicity of SARS-CoV-2 Omicron variant

Rigel Suzuki, Daichi Yamasoba, Izumi Kimura, Lei Wang et autres

In the version of this article initially published, there were presentation errors in Extended Data Fig. 7, where the first and third “Delta” images were swapped, while the first Omicron image was an inadvertent duplicate of the original first Delta image. The …

jp, Égypte (code pays fourni par la source)

Akaluc bioluminescence offers superior sensitivity to track in vivo dynamics of SARS-CoV-2 infection

Tomokazu Tamura, Hayato Ito, Shiho Torii, Lei Wang et autres

Monitoring in vivo viral dynamics can improve our understanding of pathogenicity and tissue tropism. Because the gene size of RNA viruses is typically small, NanoLuc is the primary choice for accommodation within viral genome. However, NanoLuc/Furimazine and also the conventional firefly luciferase/D-luciferin …

jp (code pays fourni par la source)

A rapid and versatile reverse genetics approach for generating recombinant positive-strand RNA viruses that use IRES-mediated translation

Tomokazu Tamura, Hirotaka Yamamoto, Saho Ogino, Yuhei Morioka et autres

ABSTRACT Reverse genetics systems have played a central role in developing recombinant viruses for a wide spectrum of virus research. The circular polymerase extension reaction (CPER) method has been applied to studying positive-strand RNA viruses, allowing researchers to bypass molecular cloning of …

jp (code pays fourni par la source)

Akaluc bioluminescence offers superior sensitivity to track in vivo dynamics of SARS-CoV-2 infection

Tomokazu Tamura, Hayato Ito, Shiho Torii, Lei Wang et autres

Summary Monitoring in vivo viral dynamics can improve our understanding of pathogenicity and tissue tropism. For positive-sense, single-stranded RNA viruses, several studies have attempted to monitor viral kinetics in vivo using reporter genomes. The application of such recombinant viruses can be limited …

jp (code pays fourni par la source)

Smoking enhances the expression of angiotensin‐converting enzyme 2 involved in the efficiency of severe acute respiratory syndrome coronavirus 2 infection

Rigel Suzuki, Yuki Ono, Koji Noshita, Kwang Su Kim et autres

Smoking is one of the risk factors most closely related to the severity of coronavirus disease 2019 (COVID-19). However, the relationship between smoking history and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infectivity is unknown. In this study, we evaluated the ACE2 …

jp, kr (code pays fourni par la source)

Secretory glycoprotein NS1 plays a crucial role in the particle formation of flaviviruses

Tomokazu Tamura, Shiho Torii, Kentaro Kajiwara, Itsuki Anzai et autres

Flaviviruses, which are globally distributed and cause a spectrum of potentially severe illnesses, pose a major threat to public health. Although Flaviviridae viruses, including flaviviruses, possess similar genome structures, only the flaviviruses encode the non-structural protein NS1, which resides in the endoplasmic …

jp (code pays fourni par la source)

Virological characteristics of the SARS-CoV-2 Omicron BA.2 spike

Daichi Yamasoba, Izumi Kimura, Hesham Nasser, Yuhei Morioka et autres

Soon after the emergence and global spread of the SARS-CoV-2 Omicron lineage BA.1, another Omicron lineage, BA.2, began outcompeting BA.1. The results of statistical analysis showed that the effective reproduction number of BA.2 is 1.4-fold higher than that of BA.1. Neutralization experiments …

jp, Égypte, il (code pays fourni par la source)

Virological characteristics of SARS-CoV-2 BA.2 variant

Daichi Yamasoba, Izumi Kimura, Hesham Nasser, Yuhei Morioka et autres

Abstract Soon after the emergence and global spread of a new severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Omicron lineage, BA.1 (ref 1, 2 ), another Omicron lineage, BA.2, has initiated outcompeting BA.1. Statistical analysis shows that the effective reproduction number of …

jp, Égypte, il (code pays fourni par la source)

Attenuated fusogenicity and pathogenicity of SARS-CoV-2 Omicron variant

Rigel Suzuki, Daichi Yamasoba, Izumi Kimura, Lei Wang et autres

Abstract The emergence of the Omicron variant of SARS-CoV-2 is an urgent global health concern 1 . In this study, our statistical modelling suggests that Omicron has spread more rapidly than the Delta variant in several countries including South Africa. Cell culture …

jp, Égypte (code pays fourni par la source)

Attenuated fusogenicity and pathogenicity of SARS-CoV-2 Omicron variant

Kei Sato, Rigel Suzuki, Daichi Yamasoba, Izumi Kimura et autres

jp (code pays fourni par la source)

DsRNA Sequencing for RNA Virus Surveillance Using Human Clinical Samples

Takuma Izumi, Yuhei Morioka, Syun‐ichi Urayama, Daisuke Motooka et autres

Although viruses infect various organs and are associated with diseases, there may be many unidentified pathogenic viruses. The recent development of next-generation sequencing technologies has facilitated the establishment of an environmental viral metagenomic approach targeting the intracellular viral genome. However, an efficient …

jp (code pays fourni par la source)

Establishment of a reverse genetics system for SARS-CoV-2 using circular polymerase extension reaction

Shiho Torii, Chikako Ono, Rigel Suzuki, Yuhei Morioka et autres

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been identified as the causative agent of coronavirus disease 2019 (COVID-19). Although multiple mutations have been observed in SARS-CoV-2, functional analysis of each mutation of SARS-CoV-2 has been limited by the lack of convenient …

jp (code pays fourni par la source)