Matti J. Tikkanen

Adipose Tissue Sex Steroids in Postmenopausal Women With and Without Menopausal Hormone Therapy

Natalia Hetemäki, Alexandra Robciuc, Veera Vihma, Mikko Haanpää et autres

CONTEXT: The decrease in serum estrogens after menopause is associated with a shift from a gynoid to an android adipose tissue (AT) distribution. Menopausal hormone therapy (HT) mitigates this change and accompanying metabolic dysfunction, but its effects on AT sex steroid metabolism …

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Association of serum cortisol and cortisone levels and risk of recurrence after endocrine treatment in breast cancer

Feng Wang, Guro Fanneløb Giskeødegård, Sissel Skarra, Monica Jernberg Engstrøm et autres

Abstract Metabolic reprogramming in breast cancer involves changes in steroid hormone synthesis and metabolism. Alterations in estrogen levels in both breast tissue and blood may influence carcinogenesis, breast cancer growth, and response to therapy. Our aim was to examine whether serum steroid …

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Supplementary Table 3 from Plasma Alkylresorcinol Metabolites as Biomarkers for Whole-Grain Intake and Their Association with Prostate Cancer: A Swedish Nested Case–Control Study

Isabel Drake, Emily Sonestedt, Bo Gullberg, Anders S Bjartell et autres

PDF - 51K, Partial correlations between plasma alkylresorcinol metabolites (DHBA+DHPPA) and various dietary variables among men of a nested case-control study in the Malmoe Diet and Cancer cohort (1991-1996).

Supplementary Table 2 from Plasma Alkylresorcinol Metabolites as Biomarkers for Whole-Grain Intake and Their Association with Prostate Cancer: A Swedish Nested Case–Control Study

Isabel Drake, Emily Sonestedt, Bo Gullberg, Anders S Bjartell et autres

PDF - 56K, Baseline characteristics of a nested case-control study in the Malmoe Diet and Cancer cohort (1991-1996) by quintiles of plasma alkylresorcinol concentrations.

Data from Plasma Alkylresorcinol Metabolites as Biomarkers for Whole-Grain Intake and Their Association with Prostate Cancer: A Swedish Nested Case–Control Study

Isabel Drake, Emily Sonestedt, Bo Gullberg, Anders S Bjartell et autres

Abstract Background: Observational studies have mostly found no association between self-reported whole-grain intake and prostate cancer. Plasma alkylresorcinol metabolites have been suggested as biomarkers for whole-grain intake in free-living populations. Methods: We investigated the major dietary and lifestyle determinants of plasma alkylresorcinol …

Adipose tissue estrogen production and metabolism in premenopausal women

Natalia Hetemäki, Tomi S. Mikkola, Matti J. Tikkanen, Feng Wang et autres

Although the ovaries produce the majority of estrogens in women before menopause, estrogen is also synthesized in peripheral tissues such as adipose tissue (AT). The typical female AT distribution, concentrated in subcutaneous and femoro-gluteal regions, is estrogen-mediated, but the significance of estrogen …

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Effect of the PCSK9 Inhibitor Evolocumab on Total Cardiovascular Events in Patients With Cardiovascular Disease

Sabina A. Murphy, Terje Rolf Pedersen, Zbigniew A. Gaciong, R Češka et autres

Importance: The PCSK9 inhibitor evolocumab reduced low-density lipoprotein cholesterol and first cardiovascular events in the Further Cardiovascular Outcomes Research With PCSK9 Inhibition in Subjects With Elevated Risk (FOURIER) trial, but patients remain at high risk of recurrent cardiovascular events. Objective: To evaluate …

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Onko LDL-kolesterolipitoisuuden pienentämisellä rajaa?

Matti J. Tikkanen

Statiinilääkitykseen yhdistettynä PCSK9-estäjät pienentävät LDL-kolesterolipitoisuutta ennennäkemättömän pieneksi. Hoitotutkimuksissa sydän- ja verisuonitapahtumat vähenevät entisestään, kun LDL-kolesterolipitoisuus lähestyy nollaa. Vielä ei tiedetä, joudutaanko tästä hyödystä maksamaan jokin hinta haittoina

Increased body fat mass and androgen metabolism – A twin study in healthy young women

Veera Vihma, Sini Heinonen, Jussi Naukkarinen, Jaakko A. Kaprio et autres

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Comparison of Low-Density Lipoprotein Cholesterol Assessment by Martin/Hopkins Estimation, Friedewald Estimation, and Preparative Ultracentrifugation

Seth Shay Martin, Robert Patrick Giugliano, Sabina A. Murphy, Scott M. Wasserman et autres

Importance: Recent studies have shown that Friedewald underestimates low-density lipoprotein cholesterol (LDL-C) at lower levels, which could result in undertreatment of high-risk patients. A novel method (Martin/Hopkins) using a patient-specific conversion factor provides more accurate LDL-C levels. However, this method has not …

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Estrogen biosynthesis in breast adipose tissue during menstrual cycle in women with and without breast cancer

Hanna M. Savolainen-Peltonen, Veera Vihma, Feng Wang, Ursula Turpeinen et autres

Circulating estrogens fluctuate during the menstrual cycle but it is not known whether this fluctuation is related to local hormone levels in adipose tissue. We analyzed estrogen concentrations and gene expression of estrogen-regulating enzymes in breast subcutaneous adipose tissue in premenopausal women …

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Abstract 15100: Reduction in Total Cardiovascular Events With the PCSK9 Inhibitor Evolocumab in Patients With Cardiovascular Disease in the FOURIER Trial

Sabina A. Murphy, Terje Rolf Pedersen, Zbigniew A. Gaciong, R Češka et autres

Introduction: Intensive LDL-C lowering with the PCSK9i evolocumab (EvoMab) significantly reduced the risk of major vascular events in pts with stable atherosclerotic disease treated on background s...