Mikko Haanpää

Effects of vaginal estrogen on serum estradiol during aromatase inhibitor therapy in breast cancer patients with vulvovaginal atrophy: a prospective trial

Mária Faltinová, Leena Vehmanen, Heli K. Lyytinen, Hanna M. Savolainen-Peltonen et autres

PURPOSE: This study aimed to analyze changes in serum estradiol (E2) levels during concurrent vaginal estradiol therapy and adjuvant letrozole in postmenopausal breast cancer (BC) patients with vulvovaginal atrophy (VVA). Secondary objectives included assessing the effects of therapy on vaginal atrophy, quality …

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Adipose Tissue Sex Steroids in Postmenopausal Women With and Without Menopausal Hormone Therapy

Natalia Hetemäki, Alexandra Robciuc, Veera Vihma, Mikko Haanpää et autres

CONTEXT: The decrease in serum estrogens after menopause is associated with a shift from a gynoid to an android adipose tissue (AT) distribution. Menopausal hormone therapy (HT) mitigates this change and accompanying metabolic dysfunction, but its effects on AT sex steroid metabolism …

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Quantification of multiple steroid hormones in serum and human breast cancer tissue by liquid chromatography-tandem mass spectrometry analysis

Feng Wang, Eline Eikeland, Randi Johansen Reidunsdatter, Lars Hagen et autres

Introduction: Systemic and local steroid hormone levels may function as novel prognostic and predictive biomarkers in breast cancer patients. We aimed at developing a novel liquid chromatography-tandem mass spectrometry (LC-MS/MS) method for the simultaneous measurement of multiple, biologically pivotal steroid hormones in …

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Effects of letrozole on serum estradiol and estrone in postmenopausal breast cancer patients and tolerability of treatment: a prospective trial using a highly sensitive LC–MS/MS (liquid chromatography–tandem mass spectrometry) method for estrogen measurement

Mária Faltinová, Leena Vehmanen, Heli K. Lyytinen, Mikko Haanpää et autres

PURPOSE: To analyze serum estradiol (E2) and estrone (E1) during letrozole treatment and their association to Quality of Life (QoL) and side-effects. METHODS: Postmenopausal breast cancer patients starting adjuvant letrozole were eligible. Serum samples were taken at baseline, three, and 12 months. …

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Effects of letrozole on serum estradiol and estrone in postmenopausal breast cancer patients and tolerability of treatment: a prospective trial using a highly sensitive LC-MS/MS (liquid chromatography-tandem mass spectrometry) method for estrogen measurement

Mária Faltinová, Leena Vehmanen, Heli K. Lyytinen, Mikko Haanpää et autres

Abstract Purpose To analyze serum estradiol (E2) and estrone (E1) during letrozole treatment and their association to Quality of life (QoL) and side-effects. Methods Postmenopausal breast cancer patients starting adjuvant letrozole were eligible. Serum samples were taken at baseline, three and 12 …

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Sex Steroid Hormone Analysis in Human Tear Fluid Using a Liquid Chromatography—Mass Spectrometry Method

Alexandra Robciuc, Hanna M. Savolainen-Peltonen, Mikko Haanpää, Jukka Moilanen et autres

The marked sexual dimorphism prevalent in inflammatory/autoimmune diseases is mostly due to sex hormone actions. One common eye disease that disproportionately affects women is dry eye. Thus, our aim was to optimise our highly sensitive liquid chromatography–tandem mass spectrometry method for steroid …

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Monitoring serum estradiol levels in breast cancer patients during extended adjuvant letrozole treatment after five years of tamoxifen: a prospective trial

Mária Faltinová, Leena Vehmanen, Heli K. Lyytinen, Mikko Haanpää et autres

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Adipose tissue estrogen production and metabolism in premenopausal women

Natalia Hetemäki, Tomi S. Mikkola, Matti J. Tikkanen, Feng Wang et autres

Although the ovaries produce the majority of estrogens in women before menopause, estrogen is also synthesized in peripheral tissues such as adipose tissue (AT). The typical female AT distribution, concentrated in subcutaneous and femoro-gluteal regions, is estrogen-mediated, but the significance of estrogen …

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Estrogen biosynthesis in breast adipose tissue during menstrual cycle in women with and without breast cancer

Hanna M. Savolainen-Peltonen, Veera Vihma, Feng Wang, Ursula Turpeinen et autres

Circulating estrogens fluctuate during the menstrual cycle but it is not known whether this fluctuation is related to local hormone levels in adipose tissue. We analyzed estrogen concentrations and gene expression of estrogen-regulating enzymes in breast subcutaneous adipose tissue in premenopausal women …

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Estrogen Metabolism in Abdominal Subcutaneous and Visceral Adipose Tissue in Postmenopausal Women

Natalia Hetemäki, Hanna M. Savolainen-Peltonen, Matti J. Tikkanen, Feng Wang et autres

Context: In postmenopausal women, adipose tissue (AT) levels of estrogens exceed circulating concentrations. Although increased visceral AT after menopause is related to metabolic diseases, little is known about differences in estrogen metabolism between different AT depots. Objective: We compared concentrations of and …

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Postnatal Ovarian Activation Has Effects in Estrogen Target Tissues in Infant Girls

Tanja Kuiri‐Hänninen, Mikko Haanpää, Ursula Turpeinen, Esa K Hämäläinen et autres

CONTEXT: Shortly after birth, pituitary gonadotropin secretion transiently activates in both sexes, and this surge is more robust in preterm (PT) than in full-term (FT) infants. In boys, the gonadotropin surge is associated with testicular activity and is considered an important part …

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Transient Postnatal Secretion of Androgen Hormones Is Associated with Acne and Sebaceous Gland Hypertrophy in Early Infancy

Tanja Kuiri‐Hänninen, Mikko Haanpää, Ursula Turpeinen, Esa K Hämäläinen et autres

CONTEXT: Sebaceous gland hypertrophy (SGH) and acne-like skin eruptions are frequent during the first months of life, yet the etiology and prevalence of these conditions in infants are not clear. OBJECTIVE: The objective of the study was to evaluate the association of …

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