Jiyoti Verma

The short-chain fatty acid crotonate reduces invasive growth and immune escape of Candida albicans by regulating hyphal gene expression

Christopher McCrory, Jiyoti Verma, Timothy M. Tucey, Rachael Turner et autres

ABSTRACT Microbes are exposed to nutritional and stress challenges in their environmental and host niches. To rise to these challenges, they regulate transcriptional programs that enable cellular adaptation. For instance, metabolite concentrations regulate post-translational modifications of chromatin, such as histone acetylation. In …

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The RSC (Remodels the Structure of Chromatin) complex of Candida albicans shows compositional divergence with distinct roles in regulating pathogenic traits

Vinutha Balachandra, Jiyoti Verma, Madhu Shankar, Timothy M. Tucey et autres

Regulation of gene expression programs is crucial for the survival of microbial pathogens in host environments and for their ability to cause disease. Here we investigated the epigenetic regulator RSC (Remodels the Structure of Chromatin) in the most prevalent human fungal pathogen …

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Metabolic competition between host and pathogen dictates inflammasome responses to fungal infection

Timothy M. Tucey, Jiyoti Verma, Françios A.B. Olivier, Tricia L. Lo et autres

The NLRP3 inflammasome has emerged as a central immune regulator that senses virulence factors expressed by microbial pathogens for triggering inflammation. Inflammation can be harmful and therefore this response must be tightly controlled. The mechanisms by which immune cells, such as macrophages, …

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The YEATS Domain Histone Crotonylation Readers Control Virulence-Related Biology of a Major Human Pathogen

Qi Wang, Jiyoti Verma, Nikolina Vidan, Yanan Wang et autres

Identification of multiple histone acylations diversifies transcriptional control by metabolism, but their functions are incompletely defined. Here we report evidence of histone crotonylation in the human fungal pathogen Candida albicans. We define the enzymes that regulate crotonylation and show its dynamic control …

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Glucose Homeostasis Is Important for Immune Cell Viability during Candida Challenge and Host Survival of Systemic Fungal Infection

Timothy M. Tucey, Jiyoti Verma, Paul F. Harrison, Sarah L. Snelgrove et autres

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Wolbachia-mediated virus blocking in mosquito cells is dependent on XRN1-mediated viral RNA degradation and influenced by viral replication rate

Saijo Thomas, Jiyoti Verma, Megan Woolfit, Scott L. O’Neill

Wolbachia is currently being developed as a novel tool to block the transmission of dengue viruses (DENV) by Aedes aegypti. A number of mechanisms have been proposed to explain the DENV-blocking phenotype in mosquitoes, including competition for fatty acids like cholesterol, manipulation …

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Multilocus sequence typing of Indian isolates of Pasteurella multocida

Raies A. Mir, P. L. Thomas, Viswas Konasagara Nagaleekar, Shashi Kant Gupta et autres

Haemorrhagic Septicemia (HS) which is caused by Pasteurella multocida accounts for heavy mortality in cattle and buffalo resulting in huge economic losses to the livestock industry. In the traditional method for typing Pasteurella multocida isolates by capsular and somatic typing the discrimination …

Basal transcription machinery: role in regulation of stress response in eukaryotes

Parag P. Sadhale, Jiyoti Verma, Aruna Naorem

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RNA polymerase II — The transcription machine

Jiyoti Verma, Aruna Naorem, Anand Kumar, Manimala Sen et autres

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Whole Genome Expression Profiles of Yeast RNA Polymerase II Core Subunit, Rpb4, in Stress and Nonstress Conditions

Beena Pillai, Jiyoti Verma, Anju Abraham, Princy Francis et autres

Organisms respond to environmental stress by adopting changes in gene expression at the transcriptional level. Rpb4, a nonessential subunit of the core RNA polymerase II has been proposed to play a role in non-stress-specific transcription and in the regulation of stress response …

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