Sarah L. Snelgrove

Regulatory T Cells Control Vascular Adhesion Molecule Expression in Skin Under Inflammatory and Homeostatic Conditions

M. Ursula Norman, Lucinda Jenkins, Pam Hall, Sarah L. Snelgrove et autres

OBJECTIVE: During skin inflammation, inhibition of adhesion of regulatory T cells (Tregs) to the dermal microvascular endothelium leads to exacerbation of inflammation, evidence that the dermal endothelium is a key target of the anti-inflammatory actions of Tregs. The aim of this study …

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Engineered antigen-specific T regulatory cells suppress autoreactivity to the anti–glomerular basement membrane disease antigen

Peter J. Eggenhuizen, Boaz H. Ng, Cecilia Lo, Janet Chang et autres

Anti–glomerular basement membrane (anti-GBM) disease is accompanied by insufficient antigen-specific regulatory T cells (Tregs) and clonally expanded antigen-specific conventional T cells. In particular, this applied to the immunodominant T cell autoepitope of type IV collagen, α3(IV)NC1 135–145 , presented by human leukocyte …

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Both Classical and Non-Classical Monocytes Patrol Glomerular Capillaries and Promote Acute Glomerular Inflammation

ZheHao Tan, Pam Hall, Matthias Mack, Sarah L. Snelgrove et autres

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Smith-specific regulatory T cells halt the progression of lupus nephritis

Peter J. Eggenhuizen, R.M. Cheong, Cecilia Lo, Janet Chang et autres

Antigen-specific regulatory T cells (Tregs) suppress pathogenic autoreactivity and are potential therapeutic candidates for autoimmune diseases such as systemic lupus erythematosus (SLE). Lupus nephritis is associated with autoreactivity to the Smith (Sm) autoantigen and the human leucocyte antigen (HLA)-DR15 haplotype; hence, we …

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CD103 Regulates Dermal Regulatory T Cell Motility and Interactions with CD11c-Expressing Leukocytes to Control Skin Inflammation

Zachary Chow, Pam Hall, Anne Cao Le, Kim Maree O’Sullivan et autres

Dermal regulatory T cells (Tregs) are essential for maintenance of skin homeostasis and control of skin inflammatory responses. In mice, Tregs in the skin are characterized by high expression of CD103, the αE integrin. Evidence indicates that CD103 promotes Treg retention within …

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T‐cell receptor αβ + double‐negative T cells in the kidney are predominantly extravascular and increase in abundance in response to ischemia–reperfusion injury

Sarah L. Snelgrove, Olivia Susanto, Louisa Yeung, Pamela Hall et autres

double-negative (DN) T cells are a population of T cells present in low abundance in blood and lymphoid organs, but enriched in various organs including the kidney. Despite burgeoning interest in these cells, studies examining their abundance in the kidney have reported …

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Dynamic Regulation of the Molecular Mechanisms of Regulatory T Cell Migration in Inflamed Skin

M. Ursula Norman, Zachary Chow, Sarah L. Snelgrove, Peemapat Prakongtham et autres

The presence of regulatory T cells (Tregs) in skin is important in controlling inflammatory responses in this peripheral tissue. Uninflamed skin contains a population of relatively immotile Tregs often located in clusters around hair follicles. Inflammation induces a significant increase both in …

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Major Histocompatibility Complex Class I restriction and expression levels : effect on type 1 diabetes onset and progression

Sarah L. Snelgrove

This thesis was scanned from the print manuscript for digital preservation and is copyright the author. Researchers can access this thesis by asking their local university, institution or public library to make a request on their behalf. Monash staff and postgraduate students …

Regulatory T Cell Transmigration and Intravascular Migration Undergo Mechanistically Distinct Regulation at Different Phases of the Inflammatory Response

Sarah L. Snelgrove, Latasha Abeynaike, Sukarnan Thevalingam, James A. Deane et autres

Regulatory T cells (Tregs) play important roles in limiting inflammatory responses in the periphery. During these responses, Treg abundance in affected organs increases and interfering with their recruitment results in exacerbation of inflammation. However, the mechanisms whereby Tregs enter the skin remain …

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Renal immune surveillance and dipeptidase-1 contribute to contrast-induced acute kidney injury

Arthur N. Lau, Hyunjae Chung, Takanori Komada, Jaye M. Platnich et autres

Radiographic contrast agents cause acute kidney injury (AKI), yet the underlying pathogenesis is poorly understood. Nod-like receptor pyrin containing 3-deficient (Nlrp3-deficient) mice displayed reduced epithelial cell injury and inflammation in the kidney in a model of contrast-induced AKI (CI-AKI). Unexpectedly, contrast agents …

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Glucose Homeostasis Is Important for Immune Cell Viability during Candida Challenge and Host Survival of Systemic Fungal Infection

Timothy M. Tucey, Jiyoti Verma, Paul Francis Harrison, Sarah L. Snelgrove et autres

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Effector CD4+ T cells recognize intravascular antigen presented by patrolling monocytes

Clare L V Westhorpe, M. Ursula Norman, Pam Hall, Sarah L. Snelgrove et autres

Abstract Although effector CD4 + T cells readily respond to antigen outside the vasculature, how they respond to intravascular antigens is unknown. Here we show the process of intravascular antigen recognition using intravital multiphoton microscopy of glomeruli. CD4 + T cells undergo …

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