Madhu Shankar

Gladiolin produced by pathogenic Burkholderia synergizes with amphotericin B through membrane lipid rearrangements

Claudia Simm, Tzong-Hsien Lee, Harshini Weerasinghe, Dean Walsh et autres

ABSTRACT Amphotericin B (AmpB) is an effective but toxic antifungal drug. Thus, improving its activity/toxicity relationship is of interest. AmpB disrupts fungal membranes by two proposed mechanisms: ergosterol sequestration from the membrane and pore formation. Whether these two mechanisms operate in conjunction …

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Immune Resolution Dilemma: Host Antimicrobial Factor S100A8/A9 Modulates Inflammatory Collateral Tissue Damage During Disseminated Fungal Peritonitis

Madhu Shankar, Nathalie Uwamahoro, Emelie Backman, Sandra Holmberg et autres

Intra-abdominal infection (peritonitis) is a leading cause of severe disease in surgical intensive care units, as over 70% of patients diagnosed with peritonitis develop septic shock. A critical role of the immune system is to return to homeostasis after combating infection. S100A8/A9 …

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The RSC (Remodels the Structure of Chromatin) complex of Candida albicans shows compositional divergence with distinct roles in regulating pathogenic traits

Vinutha Balachandra, Jiyoti Verma, Madhu Shankar, Timothy M. Tucey et autres

Regulation of gene expression programs is crucial for the survival of microbial pathogens in host environments and for their ability to cause disease. Here we investigated the epigenetic regulator RSC (Remodels the Structure of Chromatin) in the most prevalent human fungal pathogen …

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Natural Variation in Clinical Isolates of Candida albicans Modulates Neutrophil Responses

Madhu Shankar, Tricia L. Lo, Ana Traven

Neutrophils are the key immune cell type for host defenses against infections with Candida albicans . C. albicans strains isolated from patients display large phenotypic diversity, but how this diversity impacts host-pathogen interactions with neutrophils is incompletely defined. Here, we show that …

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S100A8/A9 modulates inflammatory collateral tissue damage during intraperitoneal origin systemic candidiasis

Madhu Shankar, Nathalie Uwamahoro, Sandra Holmberg, Maria J. Niemiec et autres

Abstract Peritonitis is a leading cause of severe sepsis in surgical intensive care units, as over 70% of patients diagnosed with peritonitis develop septic shock. A critical role of the immune system is to return to homeostasis after combating infection. S100A8/A9 (calprotectin) …

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Characterization of Key Bio–Nano Interactions between Organosilica Nanoparticles and Candida albicans

Vidhishri Kesarwani, Hannah G. Kelly, Madhu Shankar, Kye J. Robinson et autres

Nanoparticle–cell interactions between silica nanomaterials and mammalian cells have been investigated extensively in the context of drug delivery, diagnostics, and imaging. While there are also opportunities for applications in infectious disease, the interactions of silica nanoparticles with pathogenic microbes are relatively underexplored. …

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Additional file 4: of Correction to: Dual transcriptome of the immediate neutrophil and Candida albicans interplay

Maria J. Niemiec, Christian Grumaz, David Ermert, Christiane Desel et autres

Table ST2 A-C Differential gene expression analysis of neutrophils. Comprehensive gene expression analysis table of neutrophils infected with yeast (A) and hyphae (B). Each condition was tested against the uninfected PMN control. Union of all 318 protein-coding DEGs in neutrophils (C). (XLSX …

Additional file 11: of Correction to: Dual transcriptome of the immediate neutrophil and Candida albicans interplay

Maria J. Niemiec, Christian Grumaz, David Ermert, Christiane Desel et autres

Table ST6 Aâ D Quantification results. Comprehensive gene quantification table of neutrophil transcriptome in read counts (A) and in RPKM (B) as well as of Candida transcriptome in read counts (C) and in RPKM (D). (XLSX 18989 kb)

Additional file 2: of Correction to: Dual transcriptome of the immediate neutrophil and Candida albicans interplay

Maria J. Niemiec, Christian Grumaz, David Ermert, Christiane Desel et autres

Table ST1 Mapping results. Mapping statistics of neutrophil and Candida reads using NextGenMap. (XLS 41 kb)

Additional file 8: of Correction to: Dual transcriptome of the immediate neutrophil and Candida albicans interplay

Maria J. Niemiec, Christian Grumaz, David Ermert, Christiane Desel et autres

Table ST4 Aâ C Differential gene expression analysis of Candida. Comprehensive gene expression analysis table of neutrophil-or NET-treated Candida cells in yeast form (A) and in hyphae form (B). Respectively to the form, each condition was tested against the unchallenged, but adjusted …

Correction to: Dual transcriptome of the immediate neutrophil and Candida albicans interplay

Maria J. Niemiec, Christian Grumaz, David Ermert, Christiane Desel et autres

Art. 863, 2 S.

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Effect of reduced graphene oxide (rGO) on corrosion and erosion-corrosion behaviour of electroless Ni-P coatings

T.R. Tamilarasan, U. Sanjith, Madhu Shankar, G. Rajagopal

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