Fabrizio G. Mastronardi

Development of chemoenzymatic continuous flow processes for the preparation of biologically active compounds

Lucia Tamborini, Fabrizio G. Mastronardi, S. Cazzamalli, Paolo Zambelli

Deimination restores inner retinal visual function in murine demyelinating disease

Mabel Enriquez‐Algeciras, Di Ding, Fabrizio G. Mastronardi, Robert Edward Marc et autres

Progressive loss of visual function frequently accompanies demyelinating diseases such as multiple sclerosis (MS) and is hypothesized to be the result of damage to the axons and soma of neurons. Here, we show that dendritic impairment is also involved in these diseases. …

us (code pays fourni par la source)

GSK-3 Spatial Regulation Has an Essential Role in Lenalidomide Activity and Represents a Biomarker of Clinical Response in CLL

Suzanne Trudel, Sam E. Scanga, Fabrizio G. Mastronardi, Ellen nong Wei et autres

Abstract Abstract 1793 Thalidomide (THAL) and IMID® immunomodulary drugs lenalidomide (LEN) and (POM) have proven beneficial in the treatment of a variety of hematological malignancies. Pre-clinical studies demonstrate multiple direct and indirect anti-tumor activities including anti-angiogeneic, proapoptotic, anti-proliferative and immunomodulatory effects. Recent …

ca, us (code pays fourni par la source)

Inhibition of peptidyl-arginine deiminases reverses protein-hypercitrullination and disease in mouse models of multiple sclerosis

Mario A. Moscarello, Helena Lei, Fabrizio G. Mastronardi, Shawn Winer et autres

Multiple sclerosis (MS) is the most common CNS-demyelinating disease of humans, showing clinical and pathological heterogeneity and a general resistance to therapy. We first discovered that abnormal myelin hypercitrullination, even in normal-appearing white matter, by peptidylarginine deiminases (PADs) correlates strongly with disease …

ca, nl (code pays fourni par la source)

Innovative enzymatic (R,S)-flurbiprofen resolution in continuous flow reactor with lyophilized cells of Aspergillus oryzae

Diego Romano, Lucia Tamborini, Arianna Bertolani, Maria C. Iannuzzi et autres

Changed Histone Acetylation Patterns in Normal-Appearing White Matter and Early Multiple Sclerosis Lesions

Xiomara Pedré, Fabrizio G. Mastronardi, Wolfgang Brück, Gerardo López‐Rodas et autres

The epigenetic identity of oligodendrocytes is modulated by posttranslational modifications of histones. Acetylation of histone H3 results from the balance between the activity of histone acetyltransferases (HATs) and histone deacetylases and modulates transcriptional activation. We have previously shown that, in rodents, histone …

us, de, es (code pays fourni par la source)

Normalization of obesity-associated insulin resistance through immunotherapy

Shawn Winer, Yin Chan, Geoffrey Paltser, Dorothy Truong et autres

ca, us (code pays fourni par la source)

Development and Characterization of a Novel Hybrid Tissue Engineering–Based Scaffold for Spinal Cord Injury Repair

Nuno André Silva, António José Salgado, Rui Amandi Sousa, João Tiago Oliveira et autres

Spinal cord injury (SCI) represents a significant health and social problem, and therefore it is vital to develop novel strategies that can specifically target it. In this context, the objective of the present work was to develop a new range of three-dimensional …

pt, ca (code pays fourni par la source)

Corrigendum to “Evaluating epigenetic landmarks in the brain of multiple sclerosis patients: A contribution to the current debate on disease pathogenesis” [Prog. Neurobiol. 86 (2008) 406–416]

Patrizia Casaccia‐Bonnefil, Giovanna Pandozy, Fabrizio G. Mastronardi

us, ca (code pays fourni par la source)

Peptidylarginine deiminase 2 (PAD2) overexpression in transgenic mice leads to myelin loss in the central nervous system

Abdiwahab A. Musse, Zhen Li, Cameron A. Ackerley, Dorothee Bienzle et autres

Demyelination in the central nervous system is the hallmark feature in multiple sclerosis (MS). The mechanism resulting in destabilization of myelin is a complex multi-faceted process, part of which involves deimination of myelin basic protein (MBP). Deimination, the conversion of protein-bound arginine …

ca (code pays fourni par la source)

Peptidylarginine deiminase 2 (PAD2) overexpression in transgenic mice leads to myelin loss in the central nervous system

A. A. Musse, Z. Li, CA Ackerley, D. Bienzle et autres

Demyelination in the central nervous system is the hallmark feature in multiple sclerosis (MS).The mechanism resulting in destabilization of myelin is a complex multi-faceted process, part of which involves deimination of myelin basic protein (MBP).Deimination, the conversion of protein-bound arginine to citrulline, …

ca (code pays fourni par la source)

Evaluating epigenetic landmarks in the brain of multiple sclerosis patients: A contribution to the current debate on disease pathogenesis

Patrizia Casaccia‐Bonnefil, Giovanna Pandozy, Fabrizio G. Mastronardi

us, ca (code pays fourni par la source)