Xiomara Pedré

The Transcriptional Activator Krüppel-like Factor-6 Is Required for CNS Myelination

Benjamin M. Laitman, Linnéa Asp, John N. Mariani, Jingya Zhang et autres

Growth factors of the gp130 family promote oligodendrocyte differentiation, and viability, and myelination, but their mechanisms of action are incompletely understood. Here, we show that these effects are coordinated, in part, by the transcriptional activator Krüppel-like factor-6 (Klf6). Klf6 is rapidly induced …

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The Transcriptional Activator Krüppel-Like Factor-6 Is Required for CNS Myelination (S10.007)

Benjamin M. Laitman, Linnéa Asp, John N. Mariani, Jingya Zhang et autres

Objective: To determine the mechanism of action of Krüppel-like factor-6 (Klf6), a transcription factor found to be important for myelination. Background: Oligodendrocyte progenitors (OLP) are the main reservoir of myelinating and remyelinating cells in the CNS. Their differentiation into myelinating oligodendrocytes (OL) …

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E2F1 Coregulates Cell Cycle Genes and Chromatin Components during the Transition of Oligodendrocyte Progenitors from Proliferation to Differentiation

Laura Magri, Victoria A. Swiss, Beata Jabłońska, Lei Liang et autres

Cell cycle exit is an obligatory step for the differentiation of oligodendrocyte progenitor cells (OPCs) into myelinating cells. A key regulator of the transition from proliferation to quiescence is the E2F/Rb pathway, whose activity is highly regulated in physiological conditions and deregulated …

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Early life events effect on myelin gene expression

Gloria Luz Castilloveitia‐Vega, Xiomara Pedré, Patrizia Casaccia

Myelin is crucial for proper CNS function. It can be affected in diseases like multiple sclerosis and psychiatric disorders. Previous studies reported that children raised in abusive environment had change in white matter tracts; we therefore asked whether traumatic early life events …

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Impaired adult myelination in the prefrontal cortex of socially isolated mice

Jia Liu, Karen Dietz, Jacqueline M DeLoyht, Xiomara Pedré et autres

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Changed Histone Acetylation Patterns in Normal-Appearing White Matter and Early Multiple Sclerosis Lesions

Xiomara Pedré, Fabrizio G. Mastronardi, Wolfgang Brück, Gerardo López‐Rodas et autres

The epigenetic identity of oligodendrocytes is modulated by posttranslational modifications of histones. Acetylation of histone H3 results from the balance between the activity of histone acetyltransferases (HATs) and histone deacetylases and modulates transcriptional activation. We have previously shown that, in rodents, histone …

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Smad7 in T cells drives T helper 1 responses in multiple sclerosis and experimental autoimmune encephalomyelitis

Ingo Kleiter, Jian Song, Dominika Lukas, Maruf Hasan et autres

Autoreactive CD4+ T lymphocytes play a vital role in the pathogenesis of multiple sclerosis and its animal model, experimental autoimmune encephalomyelitis. Since the discovery of T helper 17 cells, there is an ongoing debate whether T helper 1, T helper 17 or …

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The Decoy Receptor 3 (DcR3, TNFRSF6B) suppresses Th17 immune responses and is abundant in human cerebrospinal fluid

André M. Mueller, Xiomara Pedré, Stephan Killian, Monique Antoinette David et autres

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Tracing Functional Antigen-Specific CCR6+ Th17 Cells after Vaccination

Johann Pötzl, Catherine Botteron, Eugen Tausch, Xiomara Pedré et autres

BACKGROUND: The function of T helper cell subsets in vivo depends on their location, and one hallmark of T cell differentiation is the sequential regulation of migration-inducing chemokine receptor expression. CC-chemokine receptor 6 (CCR6) is a trait of tissue-homing effector T cells …

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Novel role for SLPI in MOG-induced EAE revealed by spinal cord expression analysis

André M. Mueller, Xiomara Pedré, Thomas Stempfl, Ingo Kleiter et autres

BACKGROUND: Experimental autoimmune encephalomyelitis (EAE) induced by myelin oligodendrocyte protein (MOG) in female Dark Agouti (DA) rats is a chronic demyelinating animal model of multiple sclerosis (MS). To identify new candidate molecules involved in the evolution or repair of EAE-lesions we used …

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Inhibition of Smad7, a negative regulator of TGF-beta signaling, suppresses autoimmune encephalomyelitis

Ingo Kleiter, Xiomara Pedré, André Mueller, Peter Poeschl et autres

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Mesenchymal Stem Cells Instruct Oligodendrogenic Fate Decision on Adult Neural Stem Cells

Francisco J. Rivera, Sébastien Couillard‐Després, Xiomara Pedré, Sonja Ploetz et autres

Adult stem cells reside in different tissues and organs of the adult organism. Among these cells are MSCs that are located in the adult bone marrow and NSCs that exist in the adult central nervous system (CNS). In transplantation experiments, MSCs demonstrated …

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