B. Saffouri

48. Thiamine modulation of hepatocytes respiration.

Godliver Ngomou, Ahmed Salhab, B. Saffouri, Johnny Amer et autres

Abstract As a precursor for a key metabolic coenzyme involved in fundamental energy metabolism and mitochondrial function, thiamine (vitamin B1) is a vital nutrient for all living organisms. We previously demonstrated that high-dose thiamine administration prevented experimental fatty liver in sheep (Kalyesubula …

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THU-055-YI Novel natural killer cell immunotherapy through synthesized Neuroligin-4 peptides improved liver fibrosis

Johnny Amer, B. Saffouri, Ahmad Salhab, Rifaat Safadi

High-fat diet mouse model receiving L-glucose supplementations propagates liver injury

Johnny Amer, Athar Amleh, Ahmad Salhab, Yuval Kolodny et autres

Background and aims: Limited data link manufactured sweeteners impact on metabolic dysfunction-associated steatotic liver disease (MASLD). We aimed to evaluate the effects of manufactured sugars (L-glucose) compared to natural sugars (D-glucose) on phenotype, molecular and metabolic changes in mice models fed with …

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LBP-035 Luji-1 reduces fibrosis by blocking Neuroligin-4 and β-neurexin and overexpressing thyroid hormone receptor-b, suggesting Rezdiffra sensitization and synergism in combination

Johnny Amer, Ahmad Salhab, B. Saffouri, Ashraf Imam et autres

Novel natural killer cell immunotherapy through synthesized Neuroligin-4 peptides improved liver fibrosis

B. Saffouri, Johnny Amer, Ahmad Salhab, Rifaat Safadi

Identical patterns of somatostatin secretion from isolated antrum and fundus of rat stomach

M. L. Schubert, B. Saffouri, Gabriel M. Makhlouf

The patterns of somatostatin secretion from the fundus, the main source of somatostatin, and the antrum, the site of paracrine regulation of gastrin secretion, were examined using perifused antral and fundic segments from rat stomach. Gastrin secretion fundic segments from rat stomach. …

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Healing of benign gastric ulcer

N M Agrawal, B. Saffouri, Daniel M. Kruss, David A. Callison et autres

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Inhibition of neurally mediated gastrin secretion by bombesin antiserum

M. L. Schubert, B. Saffouri, John H. Walsh, Gabriel M. Makhlouf

In vitro studies on the vascularly perfused rat stomach have shown that gastrin secretion is regulated by intramural cholinergic and noncholinergic neurons. We have postulated that bombesin (gastrin-releasing peptide), a known gastrin stimulant present in antral mucosal nerve fibers, is the most …

Stimulation of gastrin secretion in vitro by intraluminal chemicals: Regulation by intramural cholinergic and noncholinergic neurons

B. Saffouri, Jacques Duval, G.M. Makhlouf

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Effects of Vasoactive Intestinal Peptide and Secretin on Gastrin and Somatostatin Secretion in the Perfused Rat Stomach

B. Saffouri, Jacques Duval, Akira Arimura, Gabriel M. Makhlouf

Cholinergic and Peptidergic Receptors on Isolated Human Antral Smooth Muscle Cells

K.N. Bitar, B. Saffouri, Gabriel M. Makhlouf

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Stimulation of gastrin and somatostatin secretion from the isolated rat stomach by bombesin

Jacques Duval, B. Saffouri, Gordon C. Weir, John H. Walsh et autres

The role of bombesin in the regulation of gastrin and somatostatin secretion was examined using an isolated vascularly perfused rat stomach preparation. Bombesin caused a biphasic, dose-dependent increase in gastrin and bombesin secretion. Neither somatostatin nor gastrin secretion was inhibited by atropine. …