Akira Arimura

Cytokines and the Brain

Akira Arimura, Adrian J. Dunn, Samuel M. McCann, D. Saphier

Cytokines and the Brain

Akira Arimura, Adrian J. Dunn, Samuel M. McCann, D. Saphier

Somatostatin and the Stomach

Atilla Ertan, Akira Arimura

Increased Circulating Interleukin-1 and Interleukin-6 after Intracerebroventricular Injection of Lipopolysaccharide

Paul E. Gottschall, Gen Komaki, Akira Arimura

Recently, it was demonstrated that intracerebroventricular (icv) injection of interleukin-1 (IL-1) stimulated circulating interleukin-6 (IL-6) to a greater degree than intravenous (i.v.) injection of IL-1. The goal of this study was to compare the efficacy of lipopolysaccharide (LPS), injected both icv and …

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Comparative Distribution of Immunoreactive Pituitary Adenylate Cyclase Activating Polypeptide and Vasoactive Intestinal Polypeptide in Rat Forebrain

Katalin Köves, Akira Arimura, Tamás G. Görcs, Anikó Somogyvári-Vigh

Pituitary adenylate cyclase activating polypeptide (PACAP) and vasoactive intestinal polypeptide (VIP) are structurally similar, share the same high affinity site in same peripheral tissues and increase the intracellular content of adenylate cyclase. To establish which neural circuits are signaling with each of …

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Announcement

Tamás G. Görcs, Anikó Somogyvári-Vigh, Kazuo Otake, Kunïkazu Kondo et autres

Author Index Vol. 56, 1992

Marie C. Gelato, Joseph A. Vassalotti, Elizabeth Spatola, C Rutherford et autres

Effects of Interleukin-1 on Hormone Release from Normal Rat Pituitary Cells in Primary Culture

Akira Uehara, Steven Gillis, Akira Arimura

The present study was performed mainly to determine whether interleukin-1 (IL-1), a polypeptide produced by immunologically activated monocytes, plays a physiological role in the regulation of adrenocorticotropic hormone (ACTH) using primary monolayer cultures of rat anterior pituitary cells. Neither human IL-1 alpha …

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Preoptic LH-RH and Somatostatin in the Rat Median Eminence

Jean Y. Jew, Csaba Léránth, Akira Arimura, Miklós Palkovits

Glass microknife lesions and immunocytochemistry were used to evaluate luteinizing hormone-releasing hormone (LH-RH)- and somatostatin (SS)-immunoreactive pathways from the preoptic region to the rat median eminence. Cuts were so placed that axons of more caudally located neurons in the periventricular hypothalamic areas …

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Involvement of Hypothalamic Somatostatin in the Suppression of Growth Hormone Secretion by Central Corticotropin-Releasing Factor in Conscious Male Rats

Hideki Katakami, Akira Arimura, Lawrence A. Frohman

The role of central corticotropin-releasing factor (CRF) in the regulation growth hormone (GH) secretion was studied in freely moving conscious male rats with indwelling intra-atrial and intracerebroventricular (i.c.v.) cannulae. GH measurements in blood samples obtained every 20 min from 10.00 to 14.00 …

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On the Hypothalamic Mechanism by Which Prostaglandin E 2 Stimulates Growth Hormone Release

Sergio R. Ojeda, A. Negro‐Vilar, Akira Arimura, Samuel M. McCann

It appears that prostaglandin E2 (PGE2) stimulates pituitary GH release by acting both on hypothalamic and pituitary sites. To determine if the hypothalamic components are at least in part mediated by an inhibition of somatostatin secretion, several experiments were conducted. In vivo …

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Effects of CNS Active Drugs and Somatostatin Antiserum on Growth Hormone Release in Young and Old Male Rats

William E. Sonntag, L. Forman, Nobuhiro Miki, Richard W. Steger et autres

The capacity of several potent pharmacological agents to increase growth hormone (GH) release was tested in young (3- to 4-month-old) and old (18- to 20-month-old) male Sprague-Dawley rats. Young and old animals were injected with alpha-methyl-p-tyrosine (250 mg/kg), a catecholamine synthesis inhibitor, …

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