Ahmad Salhab

Mitochondrial NCLX Couples Glucagon- and PDE2A-Dependent Signals to Regulate Hepatic Lipid Metabolism

Essam A. Assali, Mahmoud Taha, Ahmad Salhab, Johnny Amer et autres

exchanger NCLX as a key mediator of glucagon-induced mitochondrial calcium oscillations, essential for proper gluconeogenic function. Here, using hepatocyte-specific NCLX knockout (cKO) mice, we demonstrate that NCLX is critical for intrahepatic lipolysis and fatty acid oxidation (FAO); its loss impairs glucagon-stimulated lipid …

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TGR5 activation impairs lung natural killer cell function and promotes bile acid–mediated injury in metabolic liver disease

Alaa Mohammed Felel, Mohammad Jaber, Hanin Takhman, Johnny Amer et autres

Introduction and aim Bile acids (BAs) contribute to acute lung injury (ALI), yet their effects on pulmonary immune cells remain unclear. This study investigated whether elevated hepatic BA levels in metabolic dysfunction–associated steatohepatitis (MASH) promote lung injury by suppressing natural killer (NK) …

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A combined hematological and molecular study of Hodgkin lymphoma in Palestine: insights into subtype-specific prognosis and the role of Claudin-6/GATA-4

Mohammad Asees, Johnny Amer, Ayoub Rezeq, Ahmad Salhab et autres

Hodgkin Lymphoma (HL) is a heterogeneous malignant disorder in the human body's lymphatic system with distinct clinical and molecular features. The objective of this research was to assess the hematological and molecular status of HL patients in Palestine and explore potential prognostic …

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Hepatic Copper Accumulation Predicts Fibrosis Progression and Mortality in Patients with Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD)

Suha Shabaneh, Elliot M. Berry, Ashraf Imam, Mohamad Suki et autres

Background: Copper is an essential trace element involved in antioxidant defense and mitochondrial function. Evidence suggests that copper homeostasis may also influence metabolic liver diseases. We investigated the association between hepatic copper levels (HCLs) and liver-related outcomes among patients with Metabolic Dysfunction-Associated …

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Case Report: Idiopathic hypereosinophilic syndrome presenting with gastrointestinal involvement mimicking IBD: a diagnostic challenge

Johnny Amer, Fathalla Noori, Dareen Hamdan, Turkey Mokhaimar et autres

Background: Idiopathic hypereosinophilic syndrome (iHES) is a rare hematologic condition characterized by persistent, unexplained eosinophilia and organ involvement. Its diagnosis is challenging due to overlapping features with other eosinophilic and inflammatory gastrointestinal disorders. Case presentation: We report a case of a 44-year-old …

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Impact of stress and preoperative psychological preparation on immunity, inflammatory responses, and surgical outcomes in adults undergoing elective surgery with general anesthesia in Palestine

Sahar Yaseen, Reem Yaseen, Jihad Zohd, Ahmad Salhab et autres

Stress is a normal human physiological reaction that can unfavorably affect the body, such as cardiac and immunological disturbances. Several articles have shown how stress can affect the immune status. This study was designed to assess the impact of stress on the …

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Antagonizing IL-6 receptor restores pancreatic tissue resident NK cells activation and ameliorates pancreatic injury in the mouse model of MASH

Johnny Amer, Dante A. S. M. Arra, Ahmad Salhab, Faris Kayed et autres

Background and aim Metabolic-associated steatohepatitis (MASH) and pancreatic inflammation are key complications of obesity-related metabolic syndrome. Elevated IL-6; a proinflammatory cytokine, contributes to liver steatosis and pancreatic β-islet cells dysfunction. This study explores pancreatic tissue-resident (tr)NK cells IL-6 receptor (IL-6R) in pancreatic …

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Insulin Modulates NK Cell Activity in Liver Fibrosis MASH Patients via the STING Pathway

Johnny Amer, Ahmad Salhab, Amiram Ariel, Rifaat Safadi

Background: The STING (Stimulator of Interferon Genes) pathway plays a vital role in the body’s innate immune defense system, primarily involved in DNA sensing and type I interferon production. While STING is well-established in various immune cells, its role in natural killer …

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THU-055-YI Novel natural killer cell immunotherapy through synthesized Neuroligin-4 peptides improved liver fibrosis

Johnny Amer, B. Saffouri, Ahmad Salhab, Rifaat Safadi

In vitro Analysis of the Anticancer and Antidiabetic Effects of Teucrium orientale Leaf Hydrophilic Extract Grown in Two Palestinian Geographic Areas

Johnny Amer, Mustafa Ghanim, Ahmad Salhab, Nidal Jaradat et autres

Several studies have demonstrated that Teucrium orientale (T. orientale) species have therapeutic advantages, such as antioxidant, bacteriostatic, spasmolytic, and anti-inflammatory activity. This study aimed to assess the possible antidiabetic and anticancer activities of T. orientale leaf hydrophilic extracts collected from two distinct …

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A cross-sectional study of risk factors associated with sarcopenia in patients with metabolic dysfunction-associated steatotic liver disease

Johnny Amer, Qusay Abdoh, Zaina Salous, Eithar Abu Alsoud et autres

Background Metabolic dysfunction-associated steatotic liver disease (MASLD) is a chronic liver disease linked to several adverse health consequences that include metabolic disturbances affecting skeletal muscle. Sarcopenia, characterized by skeletal muscle loss, is commonly observed in individuals with MASLD. Our study aimed to …

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Neutrophilic leucocytosis as a presenting sign of primary gastric Hodgkin’s lymphoma

Mohammad Shreim, Ahmad Salhab, Mosa Abu Sabha, Akram Karama

A male patient in his 60s was admitted due to unexplained neutrophilic leucocytosis. Further diagnostic workup revealed a large gastric polyp with partial pyloric obstruction. Biopsy revealed numerous neutrophils surrounding atypical cells resembling Reed-Sternberg cells. The diagnosis of gastric Hodgkin's lymphoma was …

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