Nancy W. Troiano

Optimized Methyl methacrylate embedding of small and large undecalcified bones.

Jackie A. Fretz, Nancy W. Troiano

Methyl methacrylate (MMA) plastic embedding has been long established as a technique for the processing and histological assessment of bones. It provides the added benefit over paraffin in that it does not require decalcification of the tissue in order visualize the cellular …

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Optimized Methyl Methacrylate Embedding of Small and Large Undecalcified Bones

Jackie A. Fretz, Nancy W. Troiano

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Early B Cell Factor 1 (EBF1) Regulates Glomerular Development by Controlling Mesangial Maturation and Consequently COX-2 Expression

Tracy Nelson, Heino Velázquez, Nancy W. Troiano, Jackie A. Fretz

Significance Statement The specific mechanisms regulating formation of the glomerular tuft during renal development are largely unknown. A previous study showed the transcription factor Early B cell factor 1 (EBF1) is essential for formation of the glomerular tuft. However, the cell types …

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Selective deletion of the soluble Colony-Stimulating Factor 1 isoform in vivo prevents estrogen-deficiency bone loss in mice

Gang‐Qing Yao, Nancy W. Troiano, Christine A. Simpson, Karl Leonard Insogna

completely prevents ovariectomy (OVX)-induced bone loss in mice. There are two isoforms of CSF1, soluble (sCSF1), and membrane-bound (mCSF1), but their individual biological functions are unclear. It had been previously reported that mCSF1 knockout (K/O) and wild type (Wt) female mice experience …

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Deletion of Rac in Mature Osteoclasts Causes Osteopetrosis, an Age-Dependent Change in Osteoclast Number, and a Reduced Number of Osteoblasts In Vivo

Meiling Zhu, Ben‐hua Sun, Katarzyna Saar, Christine A. Simpson et autres

Rac1 and Rac2 are thought to have important roles in osteoclasts. Therefore, mice with deletion of both Rac1 and Rac2 in mature osteoclasts (DKO) were generated by crossing Rac1(flox/flox) mice with mice expressing Cre in the cathepsin K locus and then mating …

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Use of Osmium Tetroxide Staining with Microcomputerized Tomography to Visualize and Quantify Bone Marrow Adipose Tissue In Vivo

Erica L. Scheller, Nancy W. Troiano, Joshua N. VanHoutan, Mary A. Bouxsein et autres

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Determination of mesenchymal stem cell fate by pigment epithelium‐derived factor (PEDF) results in increased adiposity and reduced bone mineral content

Arijeet K. Gattu, E. Scott Swenson, Yasuko Iwakiri, Varman T. Samuel et autres

Pigment epithelium-derived factor (PEDF), the protein product of the SERPINF1 gene, has been linked to distinct diseases involving adipose or bone tissue, the metabolic syndrome, and osteogenesis imperfecta (OI) type VI. Since mesenchymal stem cell (MSC) differentiation into adipocytes vs. osteoblasts can …

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LIM kinase 1 deficient mice have reduced bone mass

Tsutomu Kawano, Meiling Zhu, Nancy W. Troiano, Mark C. Horowitz et autres

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Selective deletion of the membrane-bound colony stimulating factor 1 isoform leads to high bone mass but does not protect against estrogen-deficiency bone loss

Gang‐Qing Yao, Nancy W. Troiano, Meiling Zhu, Xiao-Yan Xiao et autres

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Osteoclasts Lacking Rac2 Have Defective Chemotaxis and Resorptive Activity

Takashi Itokowa, Meiling Zhu, Nancy W. Troiano, Jessica J. Bian et autres

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Targeted overexpression of Dkk1 in osteoblasts reduces bone mass but does not impair the anabolic response to intermittent PTH treatment in mice

Gang‐Qing Yao, Nancy W. Troiano, Karl Leonard Insogna

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Increased Bone Volume and Correction of HYP Mouse Hypophosphatemia in the Klotho/HYP Mouse

Catherine A. Brownstein, Junhui Zhang, Althea A. Stillman, Bruce K. Ellis et autres

Inactivating mutations of PHEX cause X-linked hypophosphatemia and result in increased circulating fibroblast growth factor 23 (FGF23). FGF23 action is dependent upon Klotho, which converts FGF receptor 1 into an FGF23-specific receptor. Disruption of Klotho results in a complex bone phenotype and …

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