Karl Insogna

Selective deletion of the membrane-bound isoform of CSF1 in vivo augments the anabolic response to PTH without impairing bone resorption

Gang‐Qing Yao, Meiling Zhu, Karl Insogna

Single daily doses of parathyroid hormone (PTH) are an established anabolic therapy for osteoporosis. The actions of PTH in bone are modulated by interactions between osteoblasts and osteoclasts. Colony-stimulating factor 1 (CSF1) exists in both soluble (sCSF1) and membrane-bound (mCSF1) isoforms, with …

us (code pays fourni par la source)

SUN-760 Finding the Needle in a Haystack: The Hunt for a Phosphaturic Tumor

Luisa Bernacet, Sean C. Peden, Dieter M. Lindskog, Gabriela Spilberg et autres

Abstract Disclosure: L. Bernacet: None. S. Peden: None. D.M. Lindskog: None. G. Spilberg: None. C. Bergwitz: Alexion Pharmaceuticals, Inc., Sanofi. K.L. Insogna: None. K. Mekala: None. Tumor-induced osteomalacia (TIO) is a rare paraneoplastic process characterized by osteomalacia from hypophosphatemia due to renal …

us (code pays fourni par la source)

3D-DXA reveals significant effects of burosumab on trabecular and cortical skeletal envelopes in symptomatic adults with X-linked hypophosphatemia

Rucha Anant Patki, Thomas O. Carpenter, Keerti Murari, Stephen Parziale et autres

Fractures and pseudofractures cause considerable morbidity in adults with X-linked hypophosphatemia (XLH). They frequently occur in cortically-enriched bones of the lower extremities. Burosumab, a neutralizing antibody to FGF23, heals fractures in adults with XLH, presumably by healing osteomalacia. Histomorphometry has documented healing …

us, es (code pays fourni par la source)

Protein Supplementation, Plasma Branched-Chain Amino Acids, and Insulin Resistance in Postmenopausal Women: An Ancillary Study from the Supplemental Protein to Outsmart Osteoporosis Now (SPOON) Trial

Jessica Bihuniak, Christine Simpson, Rebecca Sullivan, Josephine Dudzik et autres

Background/Objectives: Studies have reported an increased risk of type 2 diabetes among people with higher protein intake. Moreover, branched-chain amino acids (BCAA) are reported to be positively associated with insulin resistance (IR). However, it is not understood whether elevated levels of BCAA …

us (code pays fourni par la source)

Erratum to “PTH-dependent stabilization of RANKL mRNA is associated with increased phosphorylation of the KH-type splicing regulatory protein” [Mol. Cell. Endocrinol. 595 (2025) 112412]

Gang‐Qing Yao, Meiling Zhu, Karl Insogna

us (code pays fourni par la source)

Corrigendum to “PTH-dependent stabilization of RANKL mRNA is associated with increased phosphorylation of the KH-type splicing regulatory protein” [Molecul. Cellul. Endocrinol. 595 (2025) 112412]

Gang‐Qing Yao, Meiling Zhu, Karl Insogna

us (code pays fourni par la source)

PTH-dependent stabilization of RANKL mRNA is associated with increased phosphorylation of the KH-type splicing regulatory protein

Gang‐Qing Yao, Meiling Zhu, Karl Insogna

us (code pays fourni par la source)

Item Response Theory Quantifies the Relationship Between Improvements in Serum Phosphate and Patient‐Reported Outcomes in Adults With X‐Linked Hypophosphatemia

Krina Mehta, Nathalie H. Gosselin, Karl Insogna, Olivier Barrière et autres

Burosumab is indicated for treatment of a rare bone disease, X-linked hypophosphatemia (XLH). The aim of this analysis was to evaluate the relationship between a treatment response biomarker and patient-reported outcomes (PROs). Longitudinal data for PROs were obtained from adults with XLH …

us, gb (code pays fourni par la source)

Mitofusin 2 plays a critical role in maintaining the functional integrity of the neuromuscular-skeletal axis

Meiling Zhu, Caroline J. Zeiss, Mark W. Hamrick, Robert S. Weinstein et autres

us (code pays fourni par la source)

Pth-Dependent Stabilization of Rankl Mrna is Associated with Increased Phosphorylation of the Kh-Type Splicing Regulatory Protein

Gang Yao, Meiling Zhu, Karl Insogna

us (code pays fourni par la source)

Effect of Burosumab on Muscle Function and Strength, and Rates of ATP Synthesis in Skeletal Muscle in Adults With XLH

Karl Insogna, Rebecca Sullivan, Stephen Parziale, Yanhong Deng et autres

CONTEXT: In clinical trials, burosumab ameliorates symptoms of pain, fatigue, and stiffness and improves performance on certain muscle function studies in patients with X-linked hypophosphatemia (XLH). OBJECTIVE: This work aimed to determine if burosumab increases adenosine triphosphate (ATP) synthesis in skeletal muscle …

us (code pays fourni par la source)

Circulating Levels of Leptin and Lipocalin-2 in Patients With X-Linked Hypophosphatemia

Christine Simpson, Anna Maria Santoro, Thomas O. Carpenter, Yanhong Deng et autres

Individuals with X-linked hypophosphatemia (XLH) are at greater risk for being overweight or obese. Whether there are underlying metabolic abnormalities that put patients with XLH at greater risk for excessive weight gain is largely unknown. Lipocalin-2 (LCN2) has recently received attention as …

us (code pays fourni par la source)