Ben‐hua Sun

Mitofusin 2 plays a critical role in maintaining the functional integrity of the neuromuscular-skeletal axis

Meiling Zhu, Caroline J. Zeiss, Mark W. Hamrick, Robert S. Weinstein et autres

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An Unanticipated Role for Sphingosine Kinase-2 in Bone and in the Anabolic Effect of Parathyroid Hormone

Joanne M. Walker, Gang‐Qing Yao, Edwin Siu, Meiling Zhu et autres

Sphingosine-1-phosphate (S1P) is an anabolic clastokine. Sphingosine kinase (SPHK) is the rate-limiting enzyme in S1P production and has 2 isoforms. To evaluate the roles of SPHK1 and SPHK2 in bone, we examined the skeletal phenotype of mice with selective deletion of SPHK1 …

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Selective deletion of the receptor for CSF1, c-fms, in osteoclasts results in a high bone mass phenotype, smaller osteoclasts in vivo and an impaired response to an anabolic PTH regimen

Meiling Zhu, Ben‐hua Sun, Erin Nevius, Jared Kaplan et autres

The receptor for Colony Stimulating Factor 1 (CSF1), c-fms, is highly expressed on mature osteoclasts suggesting a role for this cytokine in regulating the function of these cells. Consistent with this idea, in vitro studies have documented a variety of effects of …

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Breast cancer-associated gene 3 interacts with Rac1 and augments NF-κB signaling in vitro, but has no effect on RANKL-induced bone resorption in vivo

Yao Chen, Kuan-Ping Yu, William M. Philbrick, Ben‐hua Sun et autres

Breast cancer-associated gene 3 (BCA3) is a recently identified adaptor protein whose functions are still being defined. BCA3 has been reported to be an important regulator of nuclear factor-κB (NF-κB) signaling. It has also been reported to interact with the small GTPase, …

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Deletion of Rac in Mature Osteoclasts Causes Osteopetrosis, an Age-Dependent Change in Osteoclast Number, and a Reduced Number of Osteoblasts In Vivo

Meiling Zhu, Ben‐hua Sun, Katarzyna Saar, Christine Simpson et autres

Rac1 and Rac2 are thought to have important roles in osteoclasts. Therefore, mice with deletion of both Rac1 and Rac2 in mature osteoclasts (DKO) were generated by crossing Rac1(flox/flox) mice with mice expressing Cre in the cathepsin K locus and then mating …

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AgRP Neurons Regulate Bone Mass

Jae Geun Kim, Ben‐hua Sun, Marcelo O. Dietrich, Marco Koch et autres

The hypothalamus has been implicated in skeletal metabolism. Whether hunger-promoting neurons of the arcuate nucleus impact the bone is not known. We generated multiple lines of mice to affect AgRP neuronal circuit integrity. We found that mice with Ucp2 gene deletion, in …

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Serum levels of sclerostin, Dickkopf-1, and secreted frizzled-related protein-4 are not changed in individuals with high bone mass causing mutations in LRP5

Christine Simpson, Dinah Foer, G. S. Lee, Jessica Bihuniak et autres

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The Transcription Factor T-box 3 Regulates Colony-stimulating Factor 1-dependent Jun Dimerization Protein 2 Expression and Plays an Important Role in Osteoclastogenesis

Yao Chen, Gang‐Qing Yao, Ben‐hua Sun, Changqing Zhang et autres

Colony-stimulating factor 1 (CSF1) is known to promote osteoclast progenitor survival, but its roles in osteoclast differentiation and mature osteoclast function are less well understood. In a microarray screen, Jun dimerization protein 2 (JDP2) was identified as significantly induced by CSF1. Recent …

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Measurement of Plasma, Serum, and Platelet Serotonin in Individuals With High Bone Mass and Mutations in LRP5

Grace S. Lee, Christine Simpson, Ben‐hua Sun, C. Andrea Yao et autres

It has recently been suggested that the low-density lipoprotein receptor-related protein 5 (LRP5) regulates bone mass by suppressing secretion of serotonin from duodenal enterochromaffin cells. In mice with targeted expression of a high bone mass-causing (HBM-causing) LRP5 mutation and in humans with …

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Increasing dietary protein acutely augments intestinal iron transporter expression and significantly increases iron absorption in rats

Carrie Thomas, Erin Gaffney‐Stomberg, Ben‐hua Sun, Kimberly O’Brien et autres

Iron (Fe) deficiency is endemic worldwide. Little data are available regarding acute effects of dietary protein on intestinal Fe absorption. The current study evaluated the short‐term effects of increasing dietary protein on Fe absorption and expression of genes involved in Fe homeostasis. …

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Dietary protein upregulates fractional intestinal iron absorption and directly increases DMT1 transcript and protein expression

C Cucchi, Erin Gaffney‐Stomberg, Ben‐hua Sun, Kimberly O’Brien et autres

Iron (Fe) deficiency is endemic worldwide. We have recently found that increasing dietary protein dose‐dependently improves Fe balance in rats. This change is associated with increased DMT1 transcript expression, a key regulator of intestinocyte Fe uptake. To confirm the Fe balance results, …

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Dietary protein increases intestinal calcium absorption in part by increasing tight junction expression of Claudin‐2

Erin Gaffney‐Stomberg, C Cucchi, Ben‐hua Sun, Amy M. Bataille et autres

High protein diets increase calcium (Ca) absorption but the mechanism is not fully understood. Gene profiling was undertaken to identify metabolic pathways involved in dietary protein's effect on Ca absorption. Female Sprague-Dawley rats were fed a low (5%, n=9) or high (40%, …

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