Xing Zhang

Moving Light Adaptive Colonoscopy Reconstruction via Illumination-Attenuation-Aware 3D Gaussian Splatting

Hao Wang, Ying Zhou, Haoyu Zhao, Rui Wang et autres

3D Gaussian Splatting (3DGS) enables real-time view synthesis in colonoscopy but assumes static illumination, making it incompatible with the strong photometric variations caused by the moving light source and camera. This mismatch leads existing methods to compensate for illumination attenuation with structure-violating …

Inhibition of inducible nitric oxide synthase (iNOS) alleviates thoracic aortic aneurysm by regulating mitochondrial dynamics

Zhi-Fa Zheng, Jiaojiao Zhang, Lifei Wu, Xuening Wang et autres

Thoracic aortic aneurysm (TAA) is life-threatening once developing to dissection (TAAD) or rupture and currently there is no effective pharmacological treatment. The abnormal activity of inducible nitric oxide synthase (iNOS) has been related with syndromic TAA, but its potential role in non-syndromic …

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Can label or protein deuteration extend the phase relaxation time of Gd(III) spin labels?

Elena V. Edinach, Xing Zhang, Chao‐Yu Cui, Yin Yang et autres

Pulse-dipolar electron paramagnetic resonance (PD-EPR) has emerged as an effective tool in structural biology, enabling distance measurements between spin labels attached to biomolecules. The sensitivity and accessible distance range of these measurements are governed by the phase memory time ( T m …

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Semaphorin 3A protects against thoracic aortic aneurysm dissection by suppressing aortic angiogenesis

Lifei Wu, Jiaojiao Zhang, Xing Zhang, Deping Wang et autres

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In Situ Quantification of Ammonia in Biofluids using High-Resolution Nuclear Magnetic Resonance

Lihua Xu, Yating Chen, Xing Zhang, Xun‐Cheng Su

Ammonia is an important metabolite and is involved in many physiological processes; the abnormal level of ammonia in vivo is correlated with the different phenotypes of diseases. Quantification of ammonia is important for disease diagnosis. However, in situ analysis of ammonia remains …

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Visualization and Quantification of Base-Level SO2 in Live Cells without Intracellular Background Interference Using Sensitive 19F-NMR

Chao‐Yu Cui, Bin Li, Xing Zhang, Shuli Guo et autres

Sulfur dioxide (SO 2 ), as an endogenous gasotransmitter, is involved in a variety of physiological processes in living systems, however, distinction and quantification of base-level SO 2 in live cells pose great challenges for the current analytical techniques. We report an …

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Sodium–glucose cotransporter 2 inhibitor increases risk of urinary tract infection: Evidence from mendelian randomization and meta‐analysis

Jie Ren, Yifei Wang, Rui Chen, Xing Zhang et autres

AIMS: Sodium-glucose cotransporter 2 inhibitor (SGLT2i) is a new hypoglycaemic drug with good effect. However, whether increased urine sugar also increases the risk of urinary tract infection (UTI) is still controversial. METHODS: Mendelian randomization (MR) was used to explore the causal relationships …

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Excellent Fe(II) Binding Tag in Protein Paramagnetic NMR Spectroscopy

Mohan Li, Xing Zhang, Baishen Pan, Xun‐Cheng Su

Most first series of transition metal ions have one or more unpaired electrons and show great variations in the paramagnetic property. The magnetic anisotropy of some transition metal ions, including Co(II), as well as lanthanide ions [Ln(III)], has been well examined in …

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Supplementary material to "Can label or protein deuteration extend the phase relaxation time of Gd(III) spin labels?"

Elena V. Edinach, Xing Zhang, Chao‐Yu Cui, Yin Yang et autres

Can label or protein deuteration extend the phase relaxation time of Gd(III) spin labels?

Elena V. Edinach, Xing Zhang, Chao‐Yu Cui, Yin Yang et autres

Abstract. Pulse-dipolar electron paramagnetic resonance (PD-EPR) has emerged as an effective tool in structural biology, enabling distance measurements between spin labels attached to biomolecules. The sensitivity and the accessible distance range of these measurements are governed by the phase memory time (Tm) …

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Rigid and stable nitroxide spin label for high-resolution distance measurements on proteins by DEER experiments

Yating Chen, Xing Zhang, Jialiang Chen, Binbin Pan et autres

The distance distributions between two site-specifically anchored spin labels in a protein, measured by pulsed electron-electron double resonance (PELDOR or DEER), provide rich sources of structural and conformational restraints on the proteins or their complexes. The rigid connection of the nitroxide spin …

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Precision labeling of proteins in live cells illustrated by in-cell 19F-NMR spectroscopy

Xun‐Cheng Su, Shuli Guo, Xing Zhang, Bin Li et autres

Deciphering protein activity in living cells, especially at atomic resolution, remains a challenge. Nuclear magnetic resonance (NMR) spectroscopy is a unique tool to provide atomic-resolution information of proteins in live cells, but most currently modification methods for proteins are not suitable for …

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